TY - JOUR
T1 - Alcohol intake and breast cancer in the European prospective investigation into cancer and nutrition
AU - Romieu, Isabelle
AU - Scoccianti, Chiara
AU - Chajès, Véronique
AU - De Batlle, Jordi
AU - Biessy, Carine
AU - Dossus, Laure
AU - Baglietto, Laura
AU - Clavel-Chapelon, Françoise
AU - Overvad, Kim
AU - Olsen, Anja
AU - Tjønneland, Anne
AU - Kaaks, Rudolf
AU - Lukanova, Annekatrin
AU - Boeing, Heiner
AU - Trichopoulou, Antonia
AU - Lagiou, Pagona
AU - Trichopoulos, Dimitrios
AU - Palli, Domenico
AU - Sieri, Sabina
AU - Tumino, Rosario
AU - Vineis, Paolo
AU - Panico, Salvatore
AU - Bueno-De-Mesquita, H. Bas
AU - Van Gils, Carla H.
AU - Peeters, Petra H.
AU - Lund, Eiliv
AU - Skeie, Guri
AU - Weiderpass, Elisabete
AU - García, José Ramõn Quirõs
AU - Chirlaque, María Dolores
AU - Ardanaz, Eva
AU - Sánchez, María José
AU - Duell, Eric J.
AU - Amiano, Pilar
AU - Borgquist, Signe
AU - Wirfält, Elisabet
AU - Hallmans, Göran
AU - Johansson, Ingegerd
AU - Nilsson, Lena Maria
AU - Khaw, Kay Tee
AU - Wareham, Nick
AU - Key, Timothy J.
AU - Travis, Ruth C.
AU - Murphy, Neil
AU - Wark, Petra A.
AU - Ferrari, Pietro
AU - Riboli, Elio
PY - 2015/10/15
Y1 - 2015/10/15
N2 - Alcohol intake has been associated to breast cancer in pre and postmenopausal women; however results are inconclusive regarding tumor hormonal receptor status, and potential modifying factors like age at start drinking. Therefore, we investigated the relation between alcohol intake and the risk of breast cancer using prospective observational data from the European Prospective Investigation into Cancer and Nutrition (EPIC). Up to 334,850 women, aged 35-70 years at baseline, were recruited in ten European countries and followed up an average of 11 years. Alcohol intake at baseline and average lifetime alcohol intake were calculated from country-specific dietary and lifestyle questionnaires. The study outcomes were the Hazard ratios (HR) of developing breast cancer according to hormonal receptor status. During 3,670,439 person-years, 11,576 incident breast cancer cases were diagnosed. Alcohol intake was significantly related to breast cancer risk, for each 10 g/day increase in alcohol intake the HR increased by 4.2% (95% CI: 2.7-5.8%). Taking 0 to 5 g/day as reference, alcohol intake of >5 to 15 g/day was related to a 5.9% increase in breast cancer risk (95% CI: 1-11%). Significant increasing trends were observed between alcohol intake and ER+/PR+, ER-/PR-, HER2- and ER-/PR-HER2- tumors. Breast cancer risk was stronger among women who started drinking prior to first full-time pregnancy. Overall, our results confirm the association between alcohol intake and both hormone receptor positive and hormone receptor negative breast tumors, suggesting that timing of exposure to alcohol drinking may affect the risk. Therefore, women should be advised to control their alcohol consumption. What's new? Although it is now established that alcohol consumption increases breast cancer risk, many questions remain. Using a prospective study design with 11,576 incident breast cancer cases across 10 European countries, the authors confirmed the increased risk of alcohol on breast cancer development. They further show that women who started drinking before their first full-term pregnancy have a higher risk than women who started afterwards. These effects were observed in hormone-receptor positive and -negative tumors pointing to non-hormonal pathways that need to be further investigated.
AB - Alcohol intake has been associated to breast cancer in pre and postmenopausal women; however results are inconclusive regarding tumor hormonal receptor status, and potential modifying factors like age at start drinking. Therefore, we investigated the relation between alcohol intake and the risk of breast cancer using prospective observational data from the European Prospective Investigation into Cancer and Nutrition (EPIC). Up to 334,850 women, aged 35-70 years at baseline, were recruited in ten European countries and followed up an average of 11 years. Alcohol intake at baseline and average lifetime alcohol intake were calculated from country-specific dietary and lifestyle questionnaires. The study outcomes were the Hazard ratios (HR) of developing breast cancer according to hormonal receptor status. During 3,670,439 person-years, 11,576 incident breast cancer cases were diagnosed. Alcohol intake was significantly related to breast cancer risk, for each 10 g/day increase in alcohol intake the HR increased by 4.2% (95% CI: 2.7-5.8%). Taking 0 to 5 g/day as reference, alcohol intake of >5 to 15 g/day was related to a 5.9% increase in breast cancer risk (95% CI: 1-11%). Significant increasing trends were observed between alcohol intake and ER+/PR+, ER-/PR-, HER2- and ER-/PR-HER2- tumors. Breast cancer risk was stronger among women who started drinking prior to first full-time pregnancy. Overall, our results confirm the association between alcohol intake and both hormone receptor positive and hormone receptor negative breast tumors, suggesting that timing of exposure to alcohol drinking may affect the risk. Therefore, women should be advised to control their alcohol consumption. What's new? Although it is now established that alcohol consumption increases breast cancer risk, many questions remain. Using a prospective study design with 11,576 incident breast cancer cases across 10 European countries, the authors confirmed the increased risk of alcohol on breast cancer development. They further show that women who started drinking before their first full-term pregnancy have a higher risk than women who started afterwards. These effects were observed in hormone-receptor positive and -negative tumors pointing to non-hormonal pathways that need to be further investigated.
KW - alcohol consumption
KW - breast cancer
KW - prospective study
U2 - 10.1002/ijc.29469
DO - 10.1002/ijc.29469
M3 - Article
C2 - 25677034
AN - SCOPUS:84938924341
SN - 0020-7136
VL - 137
SP - 1921
EP - 1930
JO - International Journal of Cancer
JF - International Journal of Cancer
IS - 8
ER -
