TY - JOUR
T1 - Alcohol drinking and endometrial cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study
AU - Fedirko, Veronika
AU - Jenab, Mazda
AU - Rinaldi, Sabina
AU - Biessy, Carine
AU - Allen, Naomi E.
AU - Dossus, Laure
AU - Onland-Moret, N. Charlotte
AU - Schütze, Madlen
AU - Tjønneland, Anne
AU - Hansen, Louise
AU - Overvad, Kim
AU - Clavel-Chapelon, Françoise
AU - Chabbert-Buffet, Nathalie
AU - Kaaks, Rudolf
AU - Lukanova, Annekatrin
AU - Bergmann, Manuela M.
AU - Boeing, Heiner
AU - Trichopoulou, Antonia
AU - Oustoglou, Erifili
AU - Barbitsioti, Antonia
AU - Saieva, Calogero
AU - Tagliabue, Giovanna
AU - Galasso, Rocco
AU - Tumino, Rosario
AU - Sacerdote, Carlotta
AU - Peeters, Petra H.
AU - Bueno-de-Mesquita, H. Bas
AU - Weiderpass, Elisabete
AU - Gram, Inger Torhild
AU - Sanchez, Soledad
AU - Duell, Eric J.
AU - Molina-Montes, Esther
AU - Arriola, Larraitz
AU - Chirlaque, Maria Dolores
AU - Ardanaz, Eva
AU - Manjer, Jonas
AU - Lundin, Eva
AU - Idahl, Annika
AU - Khaw, Kay Tee
AU - Romaguera-Bosch, Dora
AU - Wark, Petra A.
AU - Norat, Teresa
AU - Romieu, Isabelle
PY - 2013/2
Y1 - 2013/2
N2 - Purpose: Alcohol intake may adversely affect the concentrations of endogenous sex hormones, and thus increase the risk of endometrial cancer. However, epidemiologic studies have provided conflicting results. Therefore, we investigated the association between alcohol intake and endometrial cancer risk a large, multicenter, prospective study. Methods: From 1992 through 2010, 301,051 women in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort were followed for incident endometrial cancer (n = 1382). Baseline alcohol consumption was assessed by country-specific, validated dietary questionnaires. Information on past alcohol consumption was collected by lifestyle questionnaires. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated from Cox proportional hazard models. Results: The multivariable HRs (and 95% CIs) compared with light drinkers (0.1-6 g/d) were 1.03 (0.88-1.20) for 0 g of alcohol per day at baseline, 1.01 (0.86-1.17) for 6.1-12 g/d, 1.03 (0.87-1.22) for 12.1-24 g/d, 1.07 (0.87-1.38) for 24.1-36 g/d, and 0.85 (0.61-1.18) for more than 36 g/d (ptrend = 0.77). No association was observed among former drinkers (OR, 1.28; 95% CI, 0.98-1.68 compared with light drinkers). Null associations were also found between alcohol consumption at age 20 years, lifetime pattern of alcohol drinking, and baseline alcohol intake from specific alcoholic beverages and endometrial cancer risk. Conclusions: Our findings suggest no association between alcohol intake and endometrial cancer risk.
AB - Purpose: Alcohol intake may adversely affect the concentrations of endogenous sex hormones, and thus increase the risk of endometrial cancer. However, epidemiologic studies have provided conflicting results. Therefore, we investigated the association between alcohol intake and endometrial cancer risk a large, multicenter, prospective study. Methods: From 1992 through 2010, 301,051 women in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort were followed for incident endometrial cancer (n = 1382). Baseline alcohol consumption was assessed by country-specific, validated dietary questionnaires. Information on past alcohol consumption was collected by lifestyle questionnaires. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated from Cox proportional hazard models. Results: The multivariable HRs (and 95% CIs) compared with light drinkers (0.1-6 g/d) were 1.03 (0.88-1.20) for 0 g of alcohol per day at baseline, 1.01 (0.86-1.17) for 6.1-12 g/d, 1.03 (0.87-1.22) for 12.1-24 g/d, 1.07 (0.87-1.38) for 24.1-36 g/d, and 0.85 (0.61-1.18) for more than 36 g/d (ptrend = 0.77). No association was observed among former drinkers (OR, 1.28; 95% CI, 0.98-1.68 compared with light drinkers). Null associations were also found between alcohol consumption at age 20 years, lifetime pattern of alcohol drinking, and baseline alcohol intake from specific alcoholic beverages and endometrial cancer risk. Conclusions: Our findings suggest no association between alcohol intake and endometrial cancer risk.
KW - Cohort studies
KW - Endometrial neoplasms
KW - Ethanol
KW - Western Europe
U2 - 10.1016/j.annepidem.2012.11.009
DO - 10.1016/j.annepidem.2012.11.009
M3 - Article
C2 - 23273691
AN - SCOPUS:84872130945
SN - 1047-2797
VL - 23
SP - 93
EP - 98
JO - Annals of Epidemiology
JF - Annals of Epidemiology
IS - 2
ER -
