Alcohol consumption, alcohol dehydrogenase 3 polymorphism, and colorectal adenomas

Edine W. Tiemersma, Petra A. Wark, Marga C. Ocké, Annelies Bunschoten, Marten H. Otten, Frans J. Kok, Ellen Kampman

    Research output: Contribution to journalArticle

    74 Citations (Scopus)

    Abstract

    Alcohol is a probable risk factor with regard to colorectal neoplasm and is metabolized to the carcinogen acetaldehyde by the genetically polymorphic alcohol dehydrogenase 3 (ADH3) enzyme. We evaluated whether the association between alcohol and colorectal adenomas is modified by ADH3 polymorphism. We recruited 433 cases with adenomatous polyps and 436 polyp-free controls among Caucasians undergoing endoscopy between 1995 and 2000. Frequency and amount of habitual alcohol consumption were assessed by beverage type, using a validated self-administered food frequency questionnaire. All participants provided blood for genotyping of ADH3. Multivariate analyses adjusting for gender, age, and indication for endoscopy showed that alcohol increased the risk of colorectal adenomas among women [odds ratio (OR), 1.8; 95% confidence interval (CI), 1.0-3.2, ≥10 versus <1 drink/week]. Among men, the risk of adenomas was increased only for those consuming > 21 drinks/week (OR, 1.8; 95% CI, 0.9-3.8, compared with men drinking < 1 drink/week). Among subjects in the highest tertile of alcohol consumption, those with the ADH3*1/*1 genotype were at higher risk (OR, 1.8; 95% CI, 1.0-3.1) than those with other ADH3 genotypes (OR, 1.2; 95% CI, 0.7-1.9) when compared with those in the lowest tertile with ADH3*1/*2 or ADH3*2/*2 genotypes. In conclusion, our findings are consistent with results of other studies, suggesting that alcohol consumption elevates the risk of adenomatous colorectal polyps. ADH3 polymorphism may modify the association between alcohol consumption and colorectal adenomas.

    Original languageEnglish
    Pages (from-to)419-425
    Number of pages7
    JournalCancer Epidemiology Biomarkers and Prevention
    Volume12
    Issue number5
    Publication statusPublished - 1 May 2003

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    Alcohol Dehydrogenase
    Alcohol Drinking
    Adenoma
    Odds Ratio
    Confidence Intervals
    Adenomatous Polyps
    Genotype
    Alcohols
    Endoscopy
    Acetaldehyde
    Beverages
    Polyps
    Carcinogens
    Drinking
    Colorectal Neoplasms
    Multivariate Analysis
    Food
    Enzymes

    ASJC Scopus subject areas

    • Epidemiology
    • Oncology

    Cite this

    Tiemersma, E. W., Wark, P. A., Ocké, M. C., Bunschoten, A., Otten, M. H., Kok, F. J., & Kampman, E. (2003). Alcohol consumption, alcohol dehydrogenase 3 polymorphism, and colorectal adenomas. Cancer Epidemiology Biomarkers and Prevention, 12(5), 419-425.

    Alcohol consumption, alcohol dehydrogenase 3 polymorphism, and colorectal adenomas. / Tiemersma, Edine W.; Wark, Petra A.; Ocké, Marga C.; Bunschoten, Annelies; Otten, Marten H.; Kok, Frans J.; Kampman, Ellen.

    In: Cancer Epidemiology Biomarkers and Prevention, Vol. 12, No. 5, 01.05.2003, p. 419-425.

    Research output: Contribution to journalArticle

    Tiemersma, EW, Wark, PA, Ocké, MC, Bunschoten, A, Otten, MH, Kok, FJ & Kampman, E 2003, 'Alcohol consumption, alcohol dehydrogenase 3 polymorphism, and colorectal adenomas' Cancer Epidemiology Biomarkers and Prevention, vol. 12, no. 5, pp. 419-425.
    Tiemersma EW, Wark PA, Ocké MC, Bunschoten A, Otten MH, Kok FJ et al. Alcohol consumption, alcohol dehydrogenase 3 polymorphism, and colorectal adenomas. Cancer Epidemiology Biomarkers and Prevention. 2003 May 1;12(5):419-425.
    Tiemersma, Edine W. ; Wark, Petra A. ; Ocké, Marga C. ; Bunschoten, Annelies ; Otten, Marten H. ; Kok, Frans J. ; Kampman, Ellen. / Alcohol consumption, alcohol dehydrogenase 3 polymorphism, and colorectal adenomas. In: Cancer Epidemiology Biomarkers and Prevention. 2003 ; Vol. 12, No. 5. pp. 419-425.
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