Albumin-mediated extracellular zinc speciation drives cellular zinc uptake

James P C Coverdale; Hugo A. van den Berg; Siavash Khazaipoul; Hannah Bridgewater; Alan J. Stewart; Claudia A. Blindauer

doi:10.1039/D2CC02278H

Albumin-mediated extracellular zinc speciation drives cellular zinc uptake

James P C Coverdale, Hugo A. van den Berg, Siavash Khazaipoul, Hannah Bridgewater, Alan J. Stewart, Claudia A. Blindauer

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

55 Downloads (Pure)

Abstract

The role of the extracellular medium in influencing metal uptake
into cells has not been described quantitatively. In a chemically defined model system containing albumin, zinc influx into endothelial cells correlates with the extracellular free zinc concentration. Allosteric inhibition of zinc-binding to albumin by free fatty acids increased zinc flux.

Original language	English
Pages (from-to)	7384-7387
Number of pages	4
Journal	Chemical Communications
Volume	58
Issue number	53
Early online date	2 Jun 2022
DOIs	https://doi.org/10.1039/D2CC02278H
Publication status	Published - 2 Jun 2022
Externally published	Yes

Bibliographical note

This is an Open Access article distributed under the terms of the Creative
Commons Attribution License Attribution 3.0 Unported (CC BY)
which permits unrestricted use, distribution, and reproduction in any medium,
provided the original work is properly cited..

Keywords

Catalysis
Ceramics and Composites
Electronic, Optical and Magnetic Materials
General Chemistry
Materials Chemistry
Metals and Alloys
Surfaces, Coatings and Films

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Ceramics and Composites
Metals and Alloys
Materials Chemistry
Surfaces, Coatings and Films
Chemistry(all)
Catalysis

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10.1039/D2CC02278HLicence: CC BY

PublishedFinal published version, 1.7 MBLicence: CC BY
d2cc02278hFinal published version, 2.04 MBLicence: CC BY

Cite this

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title = "Albumin-mediated extracellular zinc speciation drives cellular zinc uptake",

abstract = "The role of the extracellular medium in influencing metal uptakeinto cells has not been described quantitatively. In a chemically defined model system containing albumin, zinc influx into endothelial cells correlates with the extracellular free zinc concentration. Allosteric inhibition of zinc-binding to albumin by free fatty acids increased zinc flux.",

keywords = "Catalysis, Ceramics and Composites, Electronic, Optical and Magnetic Materials, General Chemistry, Materials Chemistry, Metals and Alloys, Surfaces, Coatings and Films",

author = "Coverdale, {James P C} and {van den Berg}, {Hugo A.} and Siavash Khazaipoul and Hannah Bridgewater and Stewart, {Alan J.} and Blindauer, {Claudia A.}",

note = "This is an Open Access article distributed under the terms of the Creative Commons Attribution License Attribution 3.0 Unported (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.. ",

year = "2022",

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doi = "10.1039/D2CC02278H",

language = "English",

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T1 - Albumin-mediated extracellular zinc speciation drives cellular zinc uptake

AU - Coverdale, James P C

AU - van den Berg, Hugo A.

AU - Khazaipoul, Siavash

AU - Bridgewater, Hannah

AU - Stewart, Alan J.

AU - Blindauer, Claudia A.

N1 - This is an Open Access article distributed under the terms of the Creative Commons Attribution License Attribution 3.0 Unported (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited..

PY - 2022/6/2

Y1 - 2022/6/2

N2 - The role of the extracellular medium in influencing metal uptakeinto cells has not been described quantitatively. In a chemically defined model system containing albumin, zinc influx into endothelial cells correlates with the extracellular free zinc concentration. Allosteric inhibition of zinc-binding to albumin by free fatty acids increased zinc flux.

AB - The role of the extracellular medium in influencing metal uptakeinto cells has not been described quantitatively. In a chemically defined model system containing albumin, zinc influx into endothelial cells correlates with the extracellular free zinc concentration. Allosteric inhibition of zinc-binding to albumin by free fatty acids increased zinc flux.

KW - Catalysis

KW - Ceramics and Composites

KW - Electronic, Optical and Magnetic Materials

KW - General Chemistry

KW - Materials Chemistry

KW - Metals and Alloys

KW - Surfaces, Coatings and Films

UR - http://www.scopus.com/inward/record.url?scp=85132239507&partnerID=8YFLogxK

U2 - 10.1039/D2CC02278H

DO - 10.1039/D2CC02278H

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VL - 58

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EP - 7387

JO - Chemical Communications

JF - Chemical Communications

IS - 53

ER -

Albumin-mediated extracellular zinc speciation drives cellular zinc uptake

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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