Albumin-mediated extracellular zinc speciation drives cellular zinc uptake

James P C Coverdale, Hugo A. van den Berg, Siavash Khazaipoul, Hannah Bridgewater, Alan J. Stewart, Claudia A. Blindauer

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)
27 Downloads (Pure)


The role of the extracellular medium in influencing metal uptake
into cells has not been described quantitatively. In a chemically defined model system containing albumin, zinc influx into endothelial cells correlates with the extracellular free zinc concentration. Allosteric inhibition of zinc-binding to albumin by free fatty acids increased zinc flux.
Original languageEnglish
Pages (from-to)7384-7387
Number of pages4
JournalChemical Communications
Issue number53
Early online date2 Jun 2022
Publication statusPublished - 2 Jun 2022
Externally publishedYes

Bibliographical note

This is an Open Access article distributed under the terms of the Creative
Commons Attribution License Attribution 3.0 Unported (CC BY)
which permits unrestricted use, distribution, and reproduction in any medium,
provided the original work is properly cited..


  • Catalysis
  • Ceramics and Composites
  • Electronic, Optical and Magnetic Materials
  • General Chemistry
  • Materials Chemistry
  • Metals and Alloys
  • Surfaces, Coatings and Films

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Metals and Alloys
  • Materials Chemistry
  • Surfaces, Coatings and Films
  • Chemistry(all)
  • Catalysis


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