Acute responses of cytokines and adipokines to aerobic exercise in relapsing vs. remitting women with multiple sclerosis

Nastaran Majdinasab, Robert W. Motl, Motahare Mokhtarzade, Philipp Zimmer, Rouholah Ranjbar, Charly Keytsman, Tom Cullen, Raoof Negaresh, Julien S. Baker

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Abstract

Objective: To examine the acute effect of exercise on cytokines and adipokines during relapse and the remitting phase of multiple sclerosis (MS). Methods: Thirty women with MS in the relapsing or remitting phase were matched with fifteen healthy controls. Participants performed a single-bout of aerobic exercise at 60–70% maximal heart rate. Furthermore, five women in the relapsing phase were enrolled (control relapse) and did not receive any intervention. Blood samples were taken before, immediately after, 1-h and 6-h after the exercise. Results: Levels of IL-10 and TNF-α in response to exercise were similar in healthy and MS remitting subjects. Compared to baseline, TNF-α levels in relapsing subjects were significantly decreased immediately after exercise. Immediately following exercise, leptin levels significantly decreased in relapsing subjects. Adiponectin and IL-6 showed no significant difference between groups. Conclusion: After relapse, exercise does not induce inflammatory cytokine response and temporarily improves both cytokine and adipokine balance.
Original languageEnglish
Pages (from-to)295-301
Number of pages7
JournalComplementary Therapies in Clinical Practice
Volume31
Early online date14 Mar 2018
DOIs
Publication statusPublished - 1 May 2018
Externally publishedYes

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Adipokines
Multiple Sclerosis
Exercise
Cytokines
Recurrence
Adiponectin
Leptin
Interleukin-10
Interleukin-6
Heart Rate

Keywords

  • Adipokines
  • Aerobic interval exercise
  • Cytokines
  • Inflammation
  • Multiple sclerosis

Cite this

Acute responses of cytokines and adipokines to aerobic exercise in relapsing vs. remitting women with multiple sclerosis. / Majdinasab, Nastaran; Motl, Robert W.; Mokhtarzade, Motahare; Zimmer, Philipp; Ranjbar, Rouholah; Keytsman, Charly; Cullen, Tom; Negaresh, Raoof; Baker, Julien S.

In: Complementary Therapies in Clinical Practice, Vol. 31, 01.05.2018, p. 295-301.

Research output: Contribution to journalArticle

Majdinasab, Nastaran ; Motl, Robert W. ; Mokhtarzade, Motahare ; Zimmer, Philipp ; Ranjbar, Rouholah ; Keytsman, Charly ; Cullen, Tom ; Negaresh, Raoof ; Baker, Julien S. / Acute responses of cytokines and adipokines to aerobic exercise in relapsing vs. remitting women with multiple sclerosis. In: Complementary Therapies in Clinical Practice. 2018 ; Vol. 31. pp. 295-301.
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AU - Mokhtarzade, Motahare

AU - Zimmer, Philipp

AU - Ranjbar, Rouholah

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AU - Baker, Julien S.

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AB - Objective: To examine the acute effect of exercise on cytokines and adipokines during relapse and the remitting phase of multiple sclerosis (MS). Methods: Thirty women with MS in the relapsing or remitting phase were matched with fifteen healthy controls. Participants performed a single-bout of aerobic exercise at 60–70% maximal heart rate. Furthermore, five women in the relapsing phase were enrolled (control relapse) and did not receive any intervention. Blood samples were taken before, immediately after, 1-h and 6-h after the exercise. Results: Levels of IL-10 and TNF-α in response to exercise were similar in healthy and MS remitting subjects. Compared to baseline, TNF-α levels in relapsing subjects were significantly decreased immediately after exercise. Immediately following exercise, leptin levels significantly decreased in relapsing subjects. Adiponectin and IL-6 showed no significant difference between groups. Conclusion: After relapse, exercise does not induce inflammatory cytokine response and temporarily improves both cytokine and adipokine balance.

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