TY - JOUR
T1 - Acute responses of cytokines and adipokines to aerobic exercise in relapsing vs. remitting women with multiple sclerosis
AU - Majdinasab, Nastaran
AU - Motl, Robert W.
AU - Mokhtarzade, Motahare
AU - Zimmer, Philipp
AU - Ranjbar, Rouholah
AU - Keytsman, Charly
AU - Cullen, Tom
AU - Negaresh, Raoof
AU - Baker, Julien S.
PY - 2018/5/1
Y1 - 2018/5/1
N2 - Objective: To examine the acute effect of exercise on cytokines and adipokines during relapse and the remitting phase of multiple sclerosis (MS). Methods: Thirty women with MS in the relapsing or remitting phase were matched with fifteen healthy controls. Participants performed a single-bout of aerobic exercise at 60–70% maximal heart rate. Furthermore, five women in the relapsing phase were enrolled (control relapse) and did not receive any intervention. Blood samples were taken before, immediately after, 1-h and 6-h after the exercise. Results: Levels of IL-10 and TNF-α in response to exercise were similar in healthy and MS remitting subjects. Compared to baseline, TNF-α levels in relapsing subjects were significantly decreased immediately after exercise. Immediately following exercise, leptin levels significantly decreased in relapsing subjects. Adiponectin and IL-6 showed no significant difference between groups. Conclusion: After relapse, exercise does not induce inflammatory cytokine response and temporarily improves both cytokine and adipokine balance.
AB - Objective: To examine the acute effect of exercise on cytokines and adipokines during relapse and the remitting phase of multiple sclerosis (MS). Methods: Thirty women with MS in the relapsing or remitting phase were matched with fifteen healthy controls. Participants performed a single-bout of aerobic exercise at 60–70% maximal heart rate. Furthermore, five women in the relapsing phase were enrolled (control relapse) and did not receive any intervention. Blood samples were taken before, immediately after, 1-h and 6-h after the exercise. Results: Levels of IL-10 and TNF-α in response to exercise were similar in healthy and MS remitting subjects. Compared to baseline, TNF-α levels in relapsing subjects were significantly decreased immediately after exercise. Immediately following exercise, leptin levels significantly decreased in relapsing subjects. Adiponectin and IL-6 showed no significant difference between groups. Conclusion: After relapse, exercise does not induce inflammatory cytokine response and temporarily improves both cytokine and adipokine balance.
KW - Adipokines
KW - Aerobic interval exercise
KW - Cytokines
KW - Inflammation
KW - Multiple sclerosis
U2 - 10.1016/j.ctcp.2018.03.004
DO - 10.1016/j.ctcp.2018.03.004
M3 - Article
C2 - 29705471
SN - 1744-3881
VL - 31
SP - 295
EP - 301
JO - Complementary Therapies in Clinical Practice
JF - Complementary Therapies in Clinical Practice
ER -