Acute Exercise Stress Reveals Cerebrovascular Benefits Associated with Moderate Gains in Cardiorespiratory Fitness

J. V. Brugniaux, C. J. Marley, Danielle A. Hodson, K. J. New, D. M. Bailey

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Elevated cardiorespiratory fitness improves resting cerebral perfusion, although to what extent this is further amplified during acute exposure to exercise stress and the corresponding implications for cerebral oxygenation remain unknown. To examine this, we recruited 12 moderately active and 12 sedentary healthy males. Middle cerebral artery blood velocity (MCAv) and prefrontal cortical oxyhemoglobin (cO2Hb) concentration were monitored continuously at rest and throughout an incremental cycling test to exhaustion. Despite a subtle elevation in the maximal oxygen uptake (active: 52 ± 9 ml/kg per minute versus sedentary: 33 ± 5 ml/kg per minute, P <0.05), resting MCAv was not different between groups. However, more marked increases in both MCAv (+28 ± 13% versus +18 ± 6%, P <0.05) and cO2Hb (+5 ±4% versus −2 ± 3%, P <0.05) were observed in the active group during the transition from low- to moderate-intensity exercise. Collectively, these findings indicate that the long-term benefits associated with moderate increase in physical activity are not observed in the resting state and only become apparent when the cerebrovasculature is challenged by acute exertional stress. This has important clinical implications when assessing the true extent of cerebrovascular adaptation.
Original languageEnglish
Pages (from-to)1873-1876
JournalJournal of Cerebral Blood Flow and Metabolism
Volume34
Issue number12
Early online date1 Oct 2014
DOIs
Publication statusPublished - 1 Dec 2014
Externally publishedYes

Fingerprint

Middle Cerebral Artery
Exercise
Oxyhemoglobins
Reactive Oxygen Species
Perfusion
Cardiorespiratory Fitness

Bibliographical note

The full text is currently unavailable on the repository.

Keywords

  • cardiorespiratory fitness
  • cerebral perfusion
  • cerebrovascular adaptation
  • cortical oxygenation
  • physical activity

Cite this

Acute Exercise Stress Reveals Cerebrovascular Benefits Associated with Moderate Gains in Cardiorespiratory Fitness. / Brugniaux, J. V.; Marley, C. J.; Hodson, Danielle A.; New, K. J.; Bailey, D. M.

In: Journal of Cerebral Blood Flow and Metabolism, Vol. 34, No. 12, 01.12.2014, p. 1873-1876.

Research output: Contribution to journalArticle

Brugniaux, J. V. ; Marley, C. J. ; Hodson, Danielle A. ; New, K. J. ; Bailey, D. M. / Acute Exercise Stress Reveals Cerebrovascular Benefits Associated with Moderate Gains in Cardiorespiratory Fitness. In: Journal of Cerebral Blood Flow and Metabolism. 2014 ; Vol. 34, No. 12. pp. 1873-1876.
@article{26857693b9d34568a627d4b19d162be4,
title = "Acute Exercise Stress Reveals Cerebrovascular Benefits Associated with Moderate Gains in Cardiorespiratory Fitness",
abstract = "Elevated cardiorespiratory fitness improves resting cerebral perfusion, although to what extent this is further amplified during acute exposure to exercise stress and the corresponding implications for cerebral oxygenation remain unknown. To examine this, we recruited 12 moderately active and 12 sedentary healthy males. Middle cerebral artery blood velocity (MCAv) and prefrontal cortical oxyhemoglobin (cO2Hb) concentration were monitored continuously at rest and throughout an incremental cycling test to exhaustion. Despite a subtle elevation in the maximal oxygen uptake (active: 52 ± 9 ml/kg per minute versus sedentary: 33 ± 5 ml/kg per minute, P <0.05), resting MCAv was not different between groups. However, more marked increases in both MCAv (+28 ± 13{\%} versus +18 ± 6{\%}, P <0.05) and cO2Hb (+5 ±4{\%} versus −2 ± 3{\%}, P <0.05) were observed in the active group during the transition from low- to moderate-intensity exercise. Collectively, these findings indicate that the long-term benefits associated with moderate increase in physical activity are not observed in the resting state and only become apparent when the cerebrovasculature is challenged by acute exertional stress. This has important clinical implications when assessing the true extent of cerebrovascular adaptation.",
keywords = "cardiorespiratory fitness, cerebral perfusion, cerebrovascular adaptation, cortical oxygenation, physical activity",
author = "Brugniaux, {J. V.} and Marley, {C. J.} and Hodson, {Danielle A.} and New, {K. J.} and Bailey, {D. M.}",
note = "The full text is currently unavailable on the repository.",
year = "2014",
month = "12",
day = "1",
doi = "10.1038/jcbfm.2014.142",
language = "English",
volume = "34",
pages = "1873--1876",
journal = "Journal of Cerebral Blood Flow and Metabolism",
issn = "0271-678X",
publisher = "SAGE Publications",
number = "12",

}

TY - JOUR

T1 - Acute Exercise Stress Reveals Cerebrovascular Benefits Associated with Moderate Gains in Cardiorespiratory Fitness

AU - Brugniaux, J. V.

AU - Marley, C. J.

AU - Hodson, Danielle A.

AU - New, K. J.

AU - Bailey, D. M.

N1 - The full text is currently unavailable on the repository.

PY - 2014/12/1

Y1 - 2014/12/1

N2 - Elevated cardiorespiratory fitness improves resting cerebral perfusion, although to what extent this is further amplified during acute exposure to exercise stress and the corresponding implications for cerebral oxygenation remain unknown. To examine this, we recruited 12 moderately active and 12 sedentary healthy males. Middle cerebral artery blood velocity (MCAv) and prefrontal cortical oxyhemoglobin (cO2Hb) concentration were monitored continuously at rest and throughout an incremental cycling test to exhaustion. Despite a subtle elevation in the maximal oxygen uptake (active: 52 ± 9 ml/kg per minute versus sedentary: 33 ± 5 ml/kg per minute, P <0.05), resting MCAv was not different between groups. However, more marked increases in both MCAv (+28 ± 13% versus +18 ± 6%, P <0.05) and cO2Hb (+5 ±4% versus −2 ± 3%, P <0.05) were observed in the active group during the transition from low- to moderate-intensity exercise. Collectively, these findings indicate that the long-term benefits associated with moderate increase in physical activity are not observed in the resting state and only become apparent when the cerebrovasculature is challenged by acute exertional stress. This has important clinical implications when assessing the true extent of cerebrovascular adaptation.

AB - Elevated cardiorespiratory fitness improves resting cerebral perfusion, although to what extent this is further amplified during acute exposure to exercise stress and the corresponding implications for cerebral oxygenation remain unknown. To examine this, we recruited 12 moderately active and 12 sedentary healthy males. Middle cerebral artery blood velocity (MCAv) and prefrontal cortical oxyhemoglobin (cO2Hb) concentration were monitored continuously at rest and throughout an incremental cycling test to exhaustion. Despite a subtle elevation in the maximal oxygen uptake (active: 52 ± 9 ml/kg per minute versus sedentary: 33 ± 5 ml/kg per minute, P <0.05), resting MCAv was not different between groups. However, more marked increases in both MCAv (+28 ± 13% versus +18 ± 6%, P <0.05) and cO2Hb (+5 ±4% versus −2 ± 3%, P <0.05) were observed in the active group during the transition from low- to moderate-intensity exercise. Collectively, these findings indicate that the long-term benefits associated with moderate increase in physical activity are not observed in the resting state and only become apparent when the cerebrovasculature is challenged by acute exertional stress. This has important clinical implications when assessing the true extent of cerebrovascular adaptation.

KW - cardiorespiratory fitness

KW - cerebral perfusion

KW - cerebrovascular adaptation

KW - cortical oxygenation

KW - physical activity

U2 - 10.1038/jcbfm.2014.142

DO - 10.1038/jcbfm.2014.142

M3 - Article

VL - 34

SP - 1873

EP - 1876

JO - Journal of Cerebral Blood Flow and Metabolism

JF - Journal of Cerebral Blood Flow and Metabolism

SN - 0271-678X

IS - 12

ER -