A study of ovarian cancer biomarker amplification using ultrasound for early stage detection

D. Peng, T. Xu, Timothy J. Mason, W. Wu

    Research output: Contribution to journalArticle

    7 Citations (Scopus)
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    Abstract

    The application of serum biomarker to ovarian tumors for early stage detection and clinical diagnosis is a rapidly expanding research area. The problem with conventional markers is that they are often released too late or at too low a level to be detected in time to trigger effective treatment. Ultrasound has been used to influence bio-effects in living cells, but there is only one reported case of the use of ultrasound to enhance the release of a biomarker (Carcinoembryonic antigen CEA). In this study we report the use of ultrasound to enhance the release of a combination of ovarian cancer biomarkers (CA125 and CA19-9) to help in the diagnosis of ovarian cancer at an early stage. The results indicated that after 5 min sonication at a frequency of 1 MHz and intensity of 0.3 W cm−2, the CA125 and CA19-9 levels were increased by 2.02 and 4.21-fold respectively. These findings suggest that ultrasonic treatment can be used to enhance the release of serum biomarkers from ovarian tumors. Publisher statement: This is an Open Access report distributed under the terms of the Creative Commons Attribution Non-Commercial Share Alike License (https://creativecommons.org/licenses/by-nc-sa/3.0/), which permits users to copy, distribute and transmit the work for non-commercial purposes providing it is properly cited.
    Original languageEnglish
    Pages (from-to)451–454
    JournalUltrasonics
    Volume54
    Issue number2
    DOIs
    Publication statusPublished - 2014

    Bibliographical note

    This is an Open Access report distributed under the terms of the Creative Commons Attribution Non-Commercial Share Alike License (https://creativecommons.org/licenses/by-nc-sa/3.0/), which permits users to copy, distribute and transmit the work for non-commercial purposes providing it is properly cited.

    Chinese Ministry of Education Open Foundation for Key Laboratory of Environment Medicine and Engineering, Ministry of Education

    Keywords

    • Ovarian cancer cell line
    • Biomarker
    • Amplification
    • Ultrasound

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