A randomised controlled trial of a brief cognitive behavioural intervention for men who have hot flushes following prostate cancer treatment (MANCAN)

E. Stefanopoulou, O. Yousaf, Elizabeth A. Grunfeld, M. Hunter

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    Abstract

    Objective Hot flushes and night sweats (HFNS) are experienced by up to 80% of prostate cancer patients undergoing androgen deprivation therapy (ADT). This study evaluates the effects of a guided self-help cognitive behavioural therapy (CBT) intervention on HFNS problem-rating (primary outcome), HFNS frequency, mood and health-related quality of life (secondary outcomes) in patients undergoing ADT. Methods Patients reporting treatment-induced HFNS were randomly assigned to CBT (n = 33) or treatment as usual (TAU) (n = 35), stratified for cancer type. The CBT intervention included a booklet, CD plus telephone contact during a 4-week period. Validated self-report questionnaires were completed at baseline, 6 weeks and 32 weeks after randomisation. The primary outcome was HFNS problem rating (perceived burden of HFNS) at 6 weeks after randomisation. Potential moderators and mediators were examined. Data analysis was conducted on a modified intention-to-treat basis. Results Compared with TAU, CBT significantly reduced HFNS problem rating (adjusted mean difference: −1.33, 95% CI −2.07 to −0.58; p = 0.001) and HFNS frequency (−12.12, 95% CI −22.39 to −1.84; p = 0.02) at 6 weeks. Improvements were maintained at 32 weeks, but group differences did not reach significance. There were significant reductions in negative HFNS Beliefs and Behaviours following CBT, but not in mood or quality of life. Conclusions Guided self-help CBT appears to be a safe and effective brief treatment for men who have problematic HFNS following prostate cancer treatments. Further research might test the efficacy of the intervention in a multicentre trial
    Original languageEnglish
    Pages (from-to)1159-1166
    JournalPsycho-Oncology
    Volume24
    Issue number9
    Early online date9 Mar 2015
    DOIs
    Publication statusPublished - Sep 2015

    Bibliographical note

    This paper is available to download at: http://dx.doi.org/10.1002/pon.3794. It is an Open Online article.
    This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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