A PK-PD model of cell cycle response to topotecan

R. Ali; L. Campbell; N. D. Evans; R. J. Errington; K. R. Godfrey; P. J. Smith; M. J. Chappell

doi:10.3182/20060920-3-FR-2912.00085

A PK-PD model of cell cycle response to topotecan

R. Ali
, L. Campbell
, N. D. Evans
, R. J. Errington
, K. R. Godfrey
, P. J. Smith
, M. J. Chappell

University of Warwick
Cardiff University

Research output: Chapter in Book/Report/Conference proceeding › Conference proceeding › peer-review

2 Citations (Scopus)

Abstract

A model describing the response of the growth of single human cells in the absence and presence of the anti-cancer agent, topotecan, is presented. The model is a result of linking the pharmacokinetic (pK) and pharmacodynamic (pD) responses. By linking the models in this way, rather than using separate (static) approaches, it is possible to illustrate how the drug perturbs the cell cycle. The model is validated for a range of drug concentrations with experimental data.

Original language	English
Title of host publication	IFAC Proceedings Volumes
Publisher	Elsevier
Pages	477-482
Number of pages	6
Volume	6
Edition	PART 1
ISBN (Electronic)	9-783-9026-6118-0
DOIs	https://doi.org/10.3182/20060920-3-FR-2912.00085
Publication status	Published - 2006
Externally published	Yes
Event	6th IFAC Symposium on Modeling and Control in Biomedical Systems - Reims, France Duration: 20 Aug 2006 → 22 Aug 2006

Publication series

Name	IFAC Proceedings Volumes
Publisher	Elsevier
Number	18
Volume	39
ISSN (Print)	1474-6670

Conference

Conference	6th IFAC Symposium on Modeling and Control in Biomedical Systems
Abbreviated title	MCBMS 2006
Country/Territory	France
City	Reims
Period	20/08/06 → 22/08/06

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Compartmental models
Drug kinetics
Pharmacodynamics
Pharmacokinetics
Topotecan

ASJC Scopus subject areas

Control and Systems Engineering

Access to Document

10.3182/20060920-3-FR-2912.00085

Cite this

Ali, R, Campbell, L, Evans, ND, Errington, RJ, Godfrey, KR, Smith, PJ & Chappell, MJ 2006, A PK-PD model of cell cycle response to topotecan. in IFAC Proceedings Volumes. PART 1 edn, vol. 6, IFAC Proceedings Volumes, no. 18, vol. 39, Elsevier, pp. 477-482, 6th IFAC Symposium on Modeling and Control in Biomedical Systems, Reims, France, 20/08/06. https://doi.org/10.3182/20060920-3-FR-2912.00085

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abstract = "A model describing the response of the growth of single human cells in the absence and presence of the anti-cancer agent, topotecan, is presented. The model is a result of linking the pharmacokinetic (pK) and pharmacodynamic (pD) responses. By linking the models in this way, rather than using separate (static) approaches, it is possible to illustrate how the drug perturbs the cell cycle. The model is validated for a range of drug concentrations with experimental data.",

keywords = "Compartmental models, Drug kinetics, Pharmacodynamics, Pharmacokinetics, Topotecan",

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AU - Ali, R.

AU - Campbell, L.

AU - Evans, N. D.

AU - Errington, R. J.

AU - Godfrey, K. R.

AU - Smith, P. J.

AU - Chappell, M. J.

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AB - A model describing the response of the growth of single human cells in the absence and presence of the anti-cancer agent, topotecan, is presented. The model is a result of linking the pharmacokinetic (pK) and pharmacodynamic (pD) responses. By linking the models in this way, rather than using separate (static) approaches, it is possible to illustrate how the drug perturbs the cell cycle. The model is validated for a range of drug concentrations with experimental data.

KW - Compartmental models

KW - Drug kinetics

KW - Pharmacodynamics

KW - Pharmacokinetics

KW - Topotecan

U2 - 10.3182/20060920-3-FR-2912.00085

DO - 10.3182/20060920-3-FR-2912.00085

M3 - Conference proceeding

AN - SCOPUS:46749146460

VL - 6

T3 - IFAC Proceedings Volumes

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BT - IFAC Proceedings Volumes

PB - Elsevier

T2 - 6th IFAC Symposium on Modeling and Control in Biomedical Systems

Y2 - 20 August 2006 through 22 August 2006

ER -

A PK-PD model of cell cycle response to topotecan

Abstract

Publication series

Conference

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

Fingerprint

Cite this