A PK-PD model of cell cycle response to topotecan

R. Ali, L. Campbell, N. D. Evans, R. J. Errington, K. R. Godfrey, P. J. Smith, M. J. Chappell

Research output: Chapter in Book/Report/Conference proceedingConference proceeding

2 Citations (Scopus)

Abstract

A model describing the response of the growth of single human cells in the absence and presence of the anti-cancer agent, topotecan, is presented. The model is a result of linking the pharmacokinetic (pK) and pharmacodynamic (pD) responses. By linking the models in this way, rather than using separate (static) approaches, it is possible to illustrate how the drug perturbs the cell cycle. The model is validated for a range of drug concentrations with experimental data.

Original languageEnglish
Title of host publicationIFAC Proceedings Volumes
PublisherElsevier
Pages477-482
Number of pages6
Volume6
EditionPART 1
ISBN (Electronic)9-783-9026-6118-0
DOIs
Publication statusPublished - 2006
Externally publishedYes
Event6th IFAC Symposium on Modeling and Control in Biomedical Systems - Reims, France
Duration: 20 Aug 200622 Aug 2006

Publication series

NameIFAC Proceedings Volumes
PublisherElsevier
Number18
Volume39
ISSN (Print)1474-6670

Conference

Conference6th IFAC Symposium on Modeling and Control in Biomedical Systems
Abbreviated titleMCBMS 2006
CountryFrance
CityReims
Period20/08/0622/08/06

    Fingerprint

Keywords

  • Compartmental models
  • Drug kinetics
  • Pharmacodynamics
  • Pharmacokinetics
  • Topotecan

ASJC Scopus subject areas

  • Control and Systems Engineering

Cite this

Ali, R., Campbell, L., Evans, N. D., Errington, R. J., Godfrey, K. R., Smith, P. J., & Chappell, M. J. (2006). A PK-PD model of cell cycle response to topotecan. In IFAC Proceedings Volumes (PART 1 ed., Vol. 6, pp. 477-482). (IFAC Proceedings Volumes; Vol. 39, No. 18). Elsevier. https://doi.org/10.3182/20060920-3-FR-2912.00085