A PK-PD model of cell cycle response to topotecan

R. Ali; L. Campbell; N. D. Evans; R. J. Errington; K. R. Godfrey; P. J. Smith; M. J. Chappell

doi:10.3182/20060920-3-FR-2912.00085

A PK-PD model of cell cycle response to topotecan

R. Ali, L. Campbell, N. D. Evans, R. J. Errington, K. R. Godfrey, P. J. Smith, M. J. Chappell

Research output: Chapter in Book/Report/Conference proceeding › Conference proceeding

2 Citations (Scopus)

Abstract

A model describing the response of the growth of single human cells in the absence and presence of the anti-cancer agent, topotecan, is presented. The model is a result of linking the pharmacokinetic (pK) and pharmacodynamic (pD) responses. By linking the models in this way, rather than using separate (static) approaches, it is possible to illustrate how the drug perturbs the cell cycle. The model is validated for a range of drug concentrations with experimental data.

Original language	English
Title of host publication	IFAC Proceedings Volumes
Publisher	Elsevier
Pages	477-482
Number of pages	6
Volume	6
Edition	PART 1
ISBN (Electronic)	9-783-9026-6118-0
DOIs	https://doi.org/10.3182/20060920-3-FR-2912.00085
Publication status	Published - 2006
Externally published	Yes
Event	6th IFAC Symposium on Modeling and Control in Biomedical Systems - Reims, France Duration: 20 Aug 2006 → 22 Aug 2006

Publication series

Name	IFAC Proceedings Volumes
Publisher	Elsevier
Number	18
Volume	39
ISSN (Print)	1474-6670

Conference

Conference	6th IFAC Symposium on Modeling and Control in Biomedical Systems
Abbreviated title	MCBMS 2006
Country	France
City	Reims
Period	20/08/06 → 22/08/06

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Keywords

Compartmental models
Drug kinetics
Pharmacodynamics
Pharmacokinetics
Topotecan

ASJC Scopus subject areas

Control and Systems Engineering

Cite this

Ali, R., Campbell, L., Evans, N. D., Errington, R. J., Godfrey, K. R., Smith, P. J., & Chappell, M. J. (2006). A PK-PD model of cell cycle response to topotecan. In IFAC Proceedings Volumes (PART 1 ed., Vol. 6, pp. 477-482). (IFAC Proceedings Volumes; Vol. 39, No. 18). Elsevier. https://doi.org/10.3182/20060920-3-FR-2912.00085

Ali, R, Campbell, L, Evans, ND, Errington, RJ, Godfrey, KR, Smith, PJ & Chappell, MJ 2006, A PK-PD model of cell cycle response to topotecan. in IFAC Proceedings Volumes. PART 1 edn, vol. 6, IFAC Proceedings Volumes, no. 18, vol. 39, Elsevier, pp. 477-482, 6th IFAC Symposium on Modeling and Control in Biomedical Systems, Reims, France, 20/08/06. https://doi.org/10.3182/20060920-3-FR-2912.00085

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Access to Document

10.3182/20060920-3-FR-2912.00085