Abstract
A hybridoma producing the monoclonal antibody HIS45 was isolated from a fusion between spleen cells from a Balb/c mouse immunized with rat bone marrow cells and the fusion partner SP2/0. This antibody recognizes a determinant present on the majority of peripheral T and B cells and a small percentage of thymocytes. In a xenogeneic mixed leucocyte reaction HIS45 completely inhibits the proliferation of responding cells. HIS45 does not inhibit natural killer cell-mediated lysis. Comparison with other antibodies which have been reported to effect lymphocyte function fail to reveal any which have similar properties.
| Original language | English |
|---|---|
| Pages (from-to) | 245-252 |
| Number of pages | 8 |
| Journal | Thymus |
| Volume | 13 |
| Issue number | 3-4 |
| Publication status | Published - 1989 |
| Externally published | Yes |
ASJC Scopus subject areas
- Immunology