A novel lymphocyte surface antigen recognized by the monoclonal antibody HIS45

R. Aspinall, J. Kampinga

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

A hybridoma producing the monoclonal antibody HIS45 was isolated from a fusion between spleen cells from a Balb/c mouse immunized with rat bone marrow cells and the fusion partner SP2/0. This antibody recognizes a determinant present on the majority of peripheral T and B cells and a small percentage of thymocytes. In a xenogeneic mixed leucocyte reaction HIS45 completely inhibits the proliferation of responding cells. HIS45 does not inhibit natural killer cell-mediated lysis. Comparison with other antibodies which have been reported to effect lymphocyte function fail to reveal any which have similar properties.

Original languageEnglish
Pages (from-to)245-252
Number of pages8
JournalThymus
Volume13
Issue number3-4
Publication statusPublished - 1989
Externally publishedYes

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Surface Antigens
Monoclonal Antibodies
Lymphocytes
Mixed Lymphocyte Culture Test
Cell Fusion
Antibodies
Hybridomas
Thymocytes
Natural Killer Cells
Bone Marrow Cells
B-Lymphocytes
Spleen
Cell Proliferation
T-Lymphocytes

ASJC Scopus subject areas

  • Immunology

Cite this

A novel lymphocyte surface antigen recognized by the monoclonal antibody HIS45. / Aspinall, R.; Kampinga, J.

In: Thymus, Vol. 13, No. 3-4, 1989, p. 245-252.

Research output: Contribution to journalArticle

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