A novel lymphocyte surface antigen recognized by the monoclonal antibody HIS45

R. Aspinall, J. Kampinga

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A hybridoma producing the monoclonal antibody HIS45 was isolated from a fusion between spleen cells from a Balb/c mouse immunized with rat bone marrow cells and the fusion partner SP2/0. This antibody recognizes a determinant present on the majority of peripheral T and B cells and a small percentage of thymocytes. In a xenogeneic mixed leucocyte reaction HIS45 completely inhibits the proliferation of responding cells. HIS45 does not inhibit natural killer cell-mediated lysis. Comparison with other antibodies which have been reported to effect lymphocyte function fail to reveal any which have similar properties.

Original languageEnglish
Pages (from-to)245-252
Number of pages8
Issue number3-4
Publication statusPublished - 1989
Externally publishedYes


ASJC Scopus subject areas

  • Immunology

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