@inproceedings{26ec3b7be72645cf832a3e870f187d1f,
title = "A novel integrative bioinformatics environment for encoding and interrogating timelapse microscopy images",
abstract = "Image-derived kinetic cell-based assays, where time is the quality parameter, demand unique solutions enabling image encoding and interrogation of spatio-temporal cellular events. Our overall strategy is to derive integrated data mining tools and predictive models capable of producing in-silico cell response fingerprints for use in drug screening, experimental therapeutics and hypothesis-testing for the design of treatment regimens. Critical to realizing this aim is the development of bioinformatics and visualisation tools to address problems of cellular heterogeneity, stochasticity and scaling for the impact of drugs on cell populations and to use these tools in making fundamental advances in our understanding of drug targeting in complex neoplastic systems.",
keywords = "Bioinformatics encoding, Lineage tracking, Predictive signatures, Quercus data mining, Timelapse microscopy",
author = "Khan, {I. A.} and Hedley, {C. J.} and White, {Nick S.} and Reza Ali and Chappell, {M. J.} and Evans, {N. D.} and L. Campbell and N. Marquez and Janet Fisher and Smith, {P. J.} and Errington, {R. J.}",
year = "2006",
doi = "10.3182/20060920-3-FR-2912.00051",
language = "English",
volume = "39",
series = "IFAC Proceedings Volumes",
publisher = "Elsevier",
number = "18",
pages = "273--278",
booktitle = "IFAC Proceedings Volumes",
address = "Netherlands",
note = "6th IFAC Symposium on Modeling and Control in Biomedical Systems, MCBMS 2006 ; Conference date: 20-08-2006 Through 22-08-2006",
}