A novel integrative bioinformatics environment for encoding and interrogating timelapse microscopy images

I. A. Khan, C. J. Hedley, N. S. White, Reza Ali, M. J. Chappell, N. D. Evans, L. Campbell, N. Marquez, J. Fisher, P. J. Smith, R. J. Errington

Research output: Chapter in Book/Report/Conference proceedingConference proceeding

2 Citations (Scopus)

Abstract

Image-derived kinetic cell-based assays, where time is the quality parameter, demand unique solutions enabling image encoding and interrogation of spatio-temporal cellular events. Our overall strategy is to derive integrated data mining tools and predictive models capable of producing in-silico cell response fingerprints for use in drug screening, experimental therapeutics and hypothesis-testing for the design of treatment regimens. Critical to realizing this aim is the development of bioinformatics and visualisation tools to address problems of cellular heterogeneity, stochasticity and scaling for the impact of drugs on cell populations and to use these tools in making fundamental advances in our understanding of drug targeting in complex neoplastic systems.

Original languageEnglish
Title of host publicationIFAC Proceedings Volumes
PublisherElsevier
Pages273-278
Number of pages6
Volume39
ISBN (Electronic)978-390266118-0
DOIs
Publication statusPublished - 2006
Event6th IFAC Symposium on Modeling and Control in Biomedical Systems - Reims, France
Duration: 20 Aug 200622 Aug 2006

Publication series

NameIFAC Proceedings Volumes
PublisherElsevier
Number18
Volume39
ISSN (Electronic)1474-6670

Conference

Conference6th IFAC Symposium on Modeling and Control in Biomedical Systems
Abbreviated titleMCBMS 2006
CountryFrance
CityReims
Period20/08/0622/08/06

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Keywords

  • Bioinformatics encoding
  • Lineage tracking
  • Predictive signatures
  • Quercus data mining
  • Timelapse microscopy

ASJC Scopus subject areas

  • Control and Systems Engineering

Cite this

Khan, I. A., Hedley, C. J., White, N. S., Ali, R., Chappell, M. J., Evans, N. D., ... Errington, R. J. (2006). A novel integrative bioinformatics environment for encoding and interrogating timelapse microscopy images. In IFAC Proceedings Volumes (Vol. 39, pp. 273-278). (IFAC Proceedings Volumes; Vol. 39, No. 18). Elsevier. https://doi.org/10.3182/20060920-3-FR-2912.00051