A negative association of dietary advanced glycation end products with obesity and body composition in Iranian adults

Parivash Ghorbaninejad, Kurosh Djafarian, Nadia Babaee, Samira Davarzani, Mojdeh Ebaditabar, Cain Clark, Sakineh Shab-Bidar

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Obesity caused by excessive deposited fat, is generally classified as body mass index (BMI) ≥30 kg/m2. Research regarding the association between dietary advanced glycation end products (dAGEs) and obesity is limited. The aim of present study was to investigate the association between dAGEs and obesity and body composition in Iranian adults. This cross-sectional study included 265 adults aged 18-75 years from Tehran, Iran. Dietary AGEs was estimated using a validated semiquantitative food frequency questionnaire, according to the published food CML-AGE database for 549 routine consumed food items for the Northeastern American multiethnic urban population and was reported by dividing to total energy intake. Dietary intake, socio-demographic data and physical activity status were collected using validated questionnaires and anthropometric characteristics were measured. Body composition was assessed by bioelectrical impedance analysis (BIA) and obesity was defined based on world health organization (WHO) guidelines. The intake of fat and meat were significantly increased in higher tertiles, compared to the first tertile of dAGEs (P <0.001). No association between dAGEs and body composition measures and obesity was observed, however, there were a significant negative association between dAGEs and BMI (body mass index; P=0.01), WC (waist circumference; P=0.01), WHR (waist-to-hip ratio; P=0.03), FFM (fat free mass; P=0.02) and MMI (muscle mass index; P=0.01) in nonlinear models. In conclusion, higher consumption of dAGEs was associated with increased intake of fat and meat and was negatively related to changes in body composition measurements. Therefore dAGEs may connect obesity to diet by energy imbalance.

Original languageEnglish
Pages (from-to)(In-press)
Number of pages23
JournalBritish Journal of Nutrition
Early online date27 Jul 2020
Publication statusE-pub ahead of print - 27 Jul 2020

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  • Keywords:
  • body composition
  • dietary AGEs
  • obesity
  • receptor for AGE

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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