Abstract
The age-related decline in muscle function is aggravated by a high-fat diet (HFD)-induced increase in fat mass. The hypothesis is that an HFD leads to a faster accumulation of intramyocellular lipids (IMCL) and an earlier onset of muscle dysfunction in old than in young-adult individuals. The IMCL accumulation is attenuated in young-adult organisms by an elevated oxidative capacity. Methionine restriction enhances mitochondrial biogenesis and is promising to combat obesity across the ages.
| Original language | English |
|---|---|
| Pages (from-to) | 253-259 |
| Number of pages | 7 |
| Journal | Exercise and Sport Sciences Reviews |
| Volume | 49 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Oct 2021 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- aging
- high-fat diet
- lipotoxicity
- methionine restriction
- muscle
- muscle function
- obesity
ASJC Scopus subject areas
- Physical Therapy, Sports Therapy and Rehabilitation
- Orthopedics and Sports Medicine
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