A High-Fat Diet Aggravates the Age-Related Decline in Skeletal Muscle Structure and Function

Hans Degens; Anandini Swaminathan; Jason Tallis

doi:10.1249/jes.0000000000000261

A High-Fat Diet Aggravates the Age-Related Decline in Skeletal Muscle Structure and Function

Hans Degens, Anandini Swaminathan, Jason Tallis

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

The age-related decline in muscle function is aggravated by a high-fat diet (HFD)-induced increase in fat mass. The hypothesis is that an HFD leads to a faster accumulation of intramyocellular lipids (IMCL) and an earlier onset of muscle dysfunction in old than in young-adult individuals. The IMCL accumulation is attenuated in young-adult organisms by an elevated oxidative capacity. Methionine restriction enhances mitochondrial biogenesis and is promising to combat obesity across the ages.

Original language	English
Pages (from-to)	253-259
Number of pages	7
Journal	Exercise and Sport Sciences Reviews
Volume	49
Issue number	4
DOIs	https://doi.org/10.1249/jes.0000000000000261
Publication status	Published - Oct 2021

Keywords

aging
high-fat diet
lipotoxicity
methionine restriction
muscle
muscle function
obesity

ASJC Scopus subject areas

Physical Therapy, Sports Therapy and Rehabilitation
Orthopedics and Sports Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1249/jes.0000000000000261

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abstract = "The age-related decline in muscle function is aggravated by a high-fat diet (HFD)-induced increase in fat mass. The hypothesis is that an HFD leads to a faster accumulation of intramyocellular lipids (IMCL) and an earlier onset of muscle dysfunction in old than in young-adult individuals. The IMCL accumulation is attenuated in young-adult organisms by an elevated oxidative capacity. Methionine restriction enhances mitochondrial biogenesis and is promising to combat obesity across the ages.",

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AU - Degens, Hans

AU - Swaminathan, Anandini

AU - Tallis, Jason

PY - 2021/10

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AB - The age-related decline in muscle function is aggravated by a high-fat diet (HFD)-induced increase in fat mass. The hypothesis is that an HFD leads to a faster accumulation of intramyocellular lipids (IMCL) and an earlier onset of muscle dysfunction in old than in young-adult individuals. The IMCL accumulation is attenuated in young-adult organisms by an elevated oxidative capacity. Methionine restriction enhances mitochondrial biogenesis and is promising to combat obesity across the ages.

KW - aging

KW - high-fat diet

KW - lipotoxicity

KW - methionine restriction

KW - muscle

KW - muscle function

KW - obesity

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U2 - 10.1249/jes.0000000000000261

DO - 10.1249/jes.0000000000000261

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JO - Exercise and Sport Sciences Reviews

JF - Exercise and Sport Sciences Reviews

IS - 4

ER -

A High-Fat Diet Aggravates the Age-Related Decline in Skeletal Muscle Structure and Function

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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