A High-Fat Diet Aggravates the Age-Related Decline in Skeletal Muscle Structure and Function

Hans Degens, Anandini Swaminathan, Jason Tallis

    Research output: Contribution to journalArticlepeer-review

    4 Citations (Scopus)

    Abstract

    The age-related decline in muscle function is aggravated by a high-fat diet (HFD)-induced increase in fat mass. The hypothesis is that an HFD leads to a faster accumulation of intramyocellular lipids (IMCL) and an earlier onset of muscle dysfunction in old than in young-adult individuals. The IMCL accumulation is attenuated in young-adult organisms by an elevated oxidative capacity. Methionine restriction enhances mitochondrial biogenesis and is promising to combat obesity across the ages.
    Original languageEnglish
    Pages (from-to)253-259
    Number of pages7
    JournalExercise and Sport Sciences Reviews
    Volume49
    Issue number4
    DOIs
    Publication statusPublished - Oct 2021

    Keywords

    • aging
    • high-fat diet
    • lipotoxicity
    • methionine restriction
    • muscle
    • muscle function
    • obesity

    ASJC Scopus subject areas

    • Physical Therapy, Sports Therapy and Rehabilitation
    • Orthopedics and Sports Medicine

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