A coupled drug kinetics-cell cycle model to analyse the response of human cells to intervention by topotecan

M. J. Chappell, N. D. Evans, R. J. Errington, I. A. Khan, L. Campbell, R. Ali, K. R. Godfrey, P. J. Smith

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

A model describing the response of the growth of single human cells in the absence and presence of the anti-cancer agent topotecan (TPT) is presented. The model includes a novel coupling of both the kinetics of TPT and cell cycle responses to the agent. By linking the models in this way, rather than using separate (disjoint) approaches, it is possible to illustrate how the drug perturbs the cell cycle. The model is compared to experimental in vitro cell cycle response data (comprising single cell descriptors for molecular and behavioural events), showing good qualitative agreement for a range of TPT dose levels.

Original languageEnglish
Pages (from-to)169-178
Number of pages10
JournalComputer Methods and Programs in Biomedicine
Volume89
Issue number2
DOIs
Publication statusPublished - Feb 2008
Externally publishedYes

Fingerprint

Topotecan
Cell Cycle
Pharmacokinetics
Cells
Kinetics
Growth
Pharmaceutical Preparations
Neoplasms

Keywords

  • Cell cycle models
  • Compartmental models
  • Drug kinetics
  • Topotecan

ASJC Scopus subject areas

  • Software

Cite this

A coupled drug kinetics-cell cycle model to analyse the response of human cells to intervention by topotecan. / Chappell, M. J.; Evans, N. D.; Errington, R. J.; Khan, I. A.; Campbell, L.; Ali, R.; Godfrey, K. R.; Smith, P. J.

In: Computer Methods and Programs in Biomedicine, Vol. 89, No. 2, 02.2008, p. 169-178.

Research output: Contribution to journalArticle

Chappell, M. J. ; Evans, N. D. ; Errington, R. J. ; Khan, I. A. ; Campbell, L. ; Ali, R. ; Godfrey, K. R. ; Smith, P. J. / A coupled drug kinetics-cell cycle model to analyse the response of human cells to intervention by topotecan. In: Computer Methods and Programs in Biomedicine. 2008 ; Vol. 89, No. 2. pp. 169-178.
@article{396db6306fc84dfb99b783e9035c62e4,
title = "A coupled drug kinetics-cell cycle model to analyse the response of human cells to intervention by topotecan",
abstract = "A model describing the response of the growth of single human cells in the absence and presence of the anti-cancer agent topotecan (TPT) is presented. The model includes a novel coupling of both the kinetics of TPT and cell cycle responses to the agent. By linking the models in this way, rather than using separate (disjoint) approaches, it is possible to illustrate how the drug perturbs the cell cycle. The model is compared to experimental in vitro cell cycle response data (comprising single cell descriptors for molecular and behavioural events), showing good qualitative agreement for a range of TPT dose levels.",
keywords = "Cell cycle models, Compartmental models, Drug kinetics, Topotecan",
author = "Chappell, {M. J.} and Evans, {N. D.} and Errington, {R. J.} and Khan, {I. A.} and L. Campbell and R. Ali and Godfrey, {K. R.} and Smith, {P. J.}",
year = "2008",
month = "2",
doi = "10.1016/j.cmpb.2007.11.002",
language = "English",
volume = "89",
pages = "169--178",
journal = "Computer Methods and Programs in Biomedicine",
issn = "0169-2607",
publisher = "Elsevier",
number = "2",

}

TY - JOUR

T1 - A coupled drug kinetics-cell cycle model to analyse the response of human cells to intervention by topotecan

AU - Chappell, M. J.

AU - Evans, N. D.

AU - Errington, R. J.

AU - Khan, I. A.

AU - Campbell, L.

AU - Ali, R.

AU - Godfrey, K. R.

AU - Smith, P. J.

PY - 2008/2

Y1 - 2008/2

N2 - A model describing the response of the growth of single human cells in the absence and presence of the anti-cancer agent topotecan (TPT) is presented. The model includes a novel coupling of both the kinetics of TPT and cell cycle responses to the agent. By linking the models in this way, rather than using separate (disjoint) approaches, it is possible to illustrate how the drug perturbs the cell cycle. The model is compared to experimental in vitro cell cycle response data (comprising single cell descriptors for molecular and behavioural events), showing good qualitative agreement for a range of TPT dose levels.

AB - A model describing the response of the growth of single human cells in the absence and presence of the anti-cancer agent topotecan (TPT) is presented. The model includes a novel coupling of both the kinetics of TPT and cell cycle responses to the agent. By linking the models in this way, rather than using separate (disjoint) approaches, it is possible to illustrate how the drug perturbs the cell cycle. The model is compared to experimental in vitro cell cycle response data (comprising single cell descriptors for molecular and behavioural events), showing good qualitative agreement for a range of TPT dose levels.

KW - Cell cycle models

KW - Compartmental models

KW - Drug kinetics

KW - Topotecan

U2 - 10.1016/j.cmpb.2007.11.002

DO - 10.1016/j.cmpb.2007.11.002

M3 - Article

VL - 89

SP - 169

EP - 178

JO - Computer Methods and Programs in Biomedicine

JF - Computer Methods and Programs in Biomedicine

SN - 0169-2607

IS - 2

ER -