A model describing the response of the growth of single human cells in the absence and presence of the anti-cancer agent topotecan (TPT) is presented. The model includes a novel coupling of both the kinetics of TPT and cell cycle responses to the agent. By linking the models in this way, rather than using separate (disjoint) approaches, it is possible to illustrate how the drug perturbs the cell cycle. The model is compared to experimental in vitro cell cycle response data (comprising single cell descriptors for molecular and behavioural events), showing good qualitative agreement for a range of TPT dose levels.
|Number of pages||10|
|Journal||Computer Methods and Programs in Biomedicine|
|Publication status||Published - Feb 2008|
- Cell cycle models
- Compartmental models
- Drug kinetics
ASJC Scopus subject areas