A coupled drug kinetics-cell cycle model to analyse the response of human cells to intervention by topotecan

M. J. Chappell, N. D. Evans, R. J. Errington, I. A. Khan, L. Campbell, R. Ali, K. R. Godfrey, P. J. Smith

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

A model describing the response of the growth of single human cells in the absence and presence of the anti-cancer agent topotecan (TPT) is presented. The model includes a novel coupling of both the kinetics of TPT and cell cycle responses to the agent. By linking the models in this way, rather than using separate (disjoint) approaches, it is possible to illustrate how the drug perturbs the cell cycle. The model is compared to experimental in vitro cell cycle response data (comprising single cell descriptors for molecular and behavioural events), showing good qualitative agreement for a range of TPT dose levels.

Original languageEnglish
Pages (from-to)169-178
Number of pages10
JournalComputer Methods and Programs in Biomedicine
Volume89
Issue number2
DOIs
Publication statusPublished - Feb 2008
Externally publishedYes

    Fingerprint

Keywords

  • Cell cycle models
  • Compartmental models
  • Drug kinetics
  • Topotecan

ASJC Scopus subject areas

  • Software

Cite this