A coupled drug kinetics-cell cycle model to analyse the response of human cells to intervention by topotecan

M. J. Chappell; N. D. Evans; R. J. Errington; I. A. Khan; L. Campbell; R. Ali; K. R. Godfrey; P. J. Smith

doi:10.1016/j.cmpb.2007.11.002

A coupled drug kinetics-cell cycle model to analyse the response of human cells to intervention by topotecan

M. J. Chappell, N. D. Evans, R. J. Errington, I. A. Khan, L. Campbell, R. Ali, K. R. Godfrey, P. J. Smith

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

A model describing the response of the growth of single human cells in the absence and presence of the anti-cancer agent topotecan (TPT) is presented. The model includes a novel coupling of both the kinetics of TPT and cell cycle responses to the agent. By linking the models in this way, rather than using separate (disjoint) approaches, it is possible to illustrate how the drug perturbs the cell cycle. The model is compared to experimental in vitro cell cycle response data (comprising single cell descriptors for molecular and behavioural events), showing good qualitative agreement for a range of TPT dose levels.

Original language	English
Pages (from-to)	169-178
Number of pages	10
Journal	Computer Methods and Programs in Biomedicine
Volume	89
Issue number	2
DOIs	https://doi.org/10.1016/j.cmpb.2007.11.002
Publication status	Published - Feb 2008
Externally published	Yes

Keywords

Cell cycle models
Compartmental models
Drug kinetics
Topotecan

ASJC Scopus subject areas

Software

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.cmpb.2007.11.002

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title = "A coupled drug kinetics-cell cycle model to analyse the response of human cells to intervention by topotecan",

abstract = "A model describing the response of the growth of single human cells in the absence and presence of the anti-cancer agent topotecan (TPT) is presented. The model includes a novel coupling of both the kinetics of TPT and cell cycle responses to the agent. By linking the models in this way, rather than using separate (disjoint) approaches, it is possible to illustrate how the drug perturbs the cell cycle. The model is compared to experimental in vitro cell cycle response data (comprising single cell descriptors for molecular and behavioural events), showing good qualitative agreement for a range of TPT dose levels.",

keywords = "Cell cycle models, Compartmental models, Drug kinetics, Topotecan",

author = "Chappell, {M. J.} and Evans, {N. D.} and Errington, {R. J.} and Khan, {I. A.} and L. Campbell and R. Ali and Godfrey, {K. R.} and Smith, {P. J.}",

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T1 - A coupled drug kinetics-cell cycle model to analyse the response of human cells to intervention by topotecan

AU - Chappell, M. J.

AU - Evans, N. D.

AU - Errington, R. J.

AU - Khan, I. A.

AU - Campbell, L.

AU - Ali, R.

AU - Godfrey, K. R.

AU - Smith, P. J.

PY - 2008/2

Y1 - 2008/2

N2 - A model describing the response of the growth of single human cells in the absence and presence of the anti-cancer agent topotecan (TPT) is presented. The model includes a novel coupling of both the kinetics of TPT and cell cycle responses to the agent. By linking the models in this way, rather than using separate (disjoint) approaches, it is possible to illustrate how the drug perturbs the cell cycle. The model is compared to experimental in vitro cell cycle response data (comprising single cell descriptors for molecular and behavioural events), showing good qualitative agreement for a range of TPT dose levels.

AB - A model describing the response of the growth of single human cells in the absence and presence of the anti-cancer agent topotecan (TPT) is presented. The model includes a novel coupling of both the kinetics of TPT and cell cycle responses to the agent. By linking the models in this way, rather than using separate (disjoint) approaches, it is possible to illustrate how the drug perturbs the cell cycle. The model is compared to experimental in vitro cell cycle response data (comprising single cell descriptors for molecular and behavioural events), showing good qualitative agreement for a range of TPT dose levels.

KW - Cell cycle models

KW - Compartmental models

KW - Drug kinetics

KW - Topotecan

U2 - 10.1016/j.cmpb.2007.11.002

DO - 10.1016/j.cmpb.2007.11.002

M3 - Article

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AN - SCOPUS:37849009365

SN - 0169-2607

VL - 89

SP - 169

EP - 178

JO - Computer Methods and Programs in Biomedicine

JF - Computer Methods and Programs in Biomedicine

IS - 2

ER -

A coupled drug kinetics-cell cycle model to analyse the response of human cells to intervention by topotecan

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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