A case-control study of Dietary Approaches to Stop Hypertension (DASH) diets, colorectal cancer and adenomas among Iranian population

Saeede Jafari Nasab; Matin Ghanavati; Pegah Rafiee; Alireza Bahrami; Nazanin Majidi; Cain C.T. Clark; Amir Sadeghi; Mohammad Houshyari; Ehsan Hejazi

doi:10.1186/s12885-021-08786-5

A case-control study of Dietary Approaches to Stop Hypertension (DASH) diets, colorectal cancer and adenomas among Iranian population

Saeede Jafari Nasab, Matin Ghanavati, Pegah Rafiee, Alireza Bahrami, Nazanin Majidi, Cain C.T. Clark, Amir Sadeghi, Mohammad Houshyari, Ehsan Hejazi

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

62 Downloads (Pure)

Abstract

Background and aims: Colorectal cancer (CRC) is the third most common cancer, worldwide. Recently, much attention has been given to the association between Dietary Approaches to Stop Hypertension (DASH) and CRC, however, data on colorectal adenomas (CRAs) as its precursor are scarce. Thus, the purpose of this case-control study was to investigate the association of DASH score with the risk of CRC and CRA in Iranian adults. Method: A total of 499 participants, including 129 CRC and 130 CRA cases, along with 240 controls, were asked about their dietary intake via a validated questionnaire. The DASH score was then calculated based on a priori methods and categorized in quartiles. Multivariate logistic regression was performed to assess the association of DASH score and the risk of CRC and CRA. Results: After adjusting for confounding variables, adherence to the DASH diet was associated with a reduction in the risk of CRC and CRA, respectively (OR of 4th versus 1st quartile = 0.04, 95% CI: 0.01–0.11, OR = 0.10, 95% CI: 0.04–0.22). Also, subgroup analysis based on gender showed that women and men with a higher DASH score had a significantly lower risk of CRC and CRAs. Conclusion: The results of this study demonstrated that adherence to a DASH dietary pattern could reduce the risk of CRC and CRA in men and women. Promoting a DASH eating plan can be helpful in reducing the risk of CRC.

Original language	English
Article number	1050
Journal	BMC Cancer
Volume	21
Issue number	1
DOIs	https://doi.org/10.1186/s12885-021-08786-5
Publication status	Published - 25 Sept 2021

Bibliographical note

Funding Information:
The authors thank all study participants, without whom, the current study would have been impossible.

Publisher Copyright:
© 2021, The Author(s).

Keywords

Adenomatous polyps
Colorectal adenomas
Colorectal cancer
DASH score
Diet quality indexes
Dietary approaches to stop hypertension
Dietary indexes

ASJC Scopus subject areas

Oncology
Genetics
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1186/s12885-021-08786-5Licence: CC BY

Nasab_et_al_Case-Control_Study_BMC_CancerFinal published version, 630 KBLicence: CC BY

Cite this

@article{8f56a4ed5cd343a1a2d4a75eab6e3800,

title = "A case-control study of Dietary Approaches to Stop Hypertension (DASH) diets, colorectal cancer and adenomas among Iranian population",

abstract = "Background and aims: Colorectal cancer (CRC) is the third most common cancer, worldwide. Recently, much attention has been given to the association between Dietary Approaches to Stop Hypertension (DASH) and CRC, however, data on colorectal adenomas (CRAs) as its precursor are scarce. Thus, the purpose of this case-control study was to investigate the association of DASH score with the risk of CRC and CRA in Iranian adults. Method: A total of 499 participants, including 129 CRC and 130 CRA cases, along with 240 controls, were asked about their dietary intake via a validated questionnaire. The DASH score was then calculated based on a priori methods and categorized in quartiles. Multivariate logistic regression was performed to assess the association of DASH score and the risk of CRC and CRA. Results: After adjusting for confounding variables, adherence to the DASH diet was associated with a reduction in the risk of CRC and CRA, respectively (OR of 4th versus 1st quartile = 0.04, 95% CI: 0.01–0.11, OR = 0.10, 95% CI: 0.04–0.22). Also, subgroup analysis based on gender showed that women and men with a higher DASH score had a significantly lower risk of CRC and CRAs. Conclusion: The results of this study demonstrated that adherence to a DASH dietary pattern could reduce the risk of CRC and CRA in men and women. Promoting a DASH eating plan can be helpful in reducing the risk of CRC.",

keywords = "Adenomatous polyps, Colorectal adenomas, Colorectal cancer, DASH score, Diet quality indexes, Dietary approaches to stop hypertension, Dietary indexes",

author = "{Jafari Nasab}, Saeede and Matin Ghanavati and Pegah Rafiee and Alireza Bahrami and Nazanin Majidi and Clark, {Cain C.T.} and Amir Sadeghi and Mohammad Houshyari and Ehsan Hejazi",

note = "Funding Information: The authors thank all study participants, without whom, the current study would have been impossible. Publisher Copyright: {\textcopyright} 2021, The Author(s).",

year = "2021",

month = sep,

day = "25",

doi = "10.1186/s12885-021-08786-5",

language = "English",

volume = "21",

journal = "BMC Cancer",

issn = "1471-2407",

publisher = "BioMed Central",

number = "1",

}

TY - JOUR

T1 - A case-control study of Dietary Approaches to Stop Hypertension (DASH) diets, colorectal cancer and adenomas among Iranian population

AU - Jafari Nasab, Saeede

AU - Ghanavati, Matin

AU - Rafiee, Pegah

AU - Bahrami, Alireza

AU - Majidi, Nazanin

AU - Clark, Cain C.T.

AU - Sadeghi, Amir

AU - Houshyari, Mohammad

AU - Hejazi, Ehsan

PY - 2021/9/25

Y1 - 2021/9/25

N2 - Background and aims: Colorectal cancer (CRC) is the third most common cancer, worldwide. Recently, much attention has been given to the association between Dietary Approaches to Stop Hypertension (DASH) and CRC, however, data on colorectal adenomas (CRAs) as its precursor are scarce. Thus, the purpose of this case-control study was to investigate the association of DASH score with the risk of CRC and CRA in Iranian adults. Method: A total of 499 participants, including 129 CRC and 130 CRA cases, along with 240 controls, were asked about their dietary intake via a validated questionnaire. The DASH score was then calculated based on a priori methods and categorized in quartiles. Multivariate logistic regression was performed to assess the association of DASH score and the risk of CRC and CRA. Results: After adjusting for confounding variables, adherence to the DASH diet was associated with a reduction in the risk of CRC and CRA, respectively (OR of 4th versus 1st quartile = 0.04, 95% CI: 0.01–0.11, OR = 0.10, 95% CI: 0.04–0.22). Also, subgroup analysis based on gender showed that women and men with a higher DASH score had a significantly lower risk of CRC and CRAs. Conclusion: The results of this study demonstrated that adherence to a DASH dietary pattern could reduce the risk of CRC and CRA in men and women. Promoting a DASH eating plan can be helpful in reducing the risk of CRC.

AB - Background and aims: Colorectal cancer (CRC) is the third most common cancer, worldwide. Recently, much attention has been given to the association between Dietary Approaches to Stop Hypertension (DASH) and CRC, however, data on colorectal adenomas (CRAs) as its precursor are scarce. Thus, the purpose of this case-control study was to investigate the association of DASH score with the risk of CRC and CRA in Iranian adults. Method: A total of 499 participants, including 129 CRC and 130 CRA cases, along with 240 controls, were asked about their dietary intake via a validated questionnaire. The DASH score was then calculated based on a priori methods and categorized in quartiles. Multivariate logistic regression was performed to assess the association of DASH score and the risk of CRC and CRA. Results: After adjusting for confounding variables, adherence to the DASH diet was associated with a reduction in the risk of CRC and CRA, respectively (OR of 4th versus 1st quartile = 0.04, 95% CI: 0.01–0.11, OR = 0.10, 95% CI: 0.04–0.22). Also, subgroup analysis based on gender showed that women and men with a higher DASH score had a significantly lower risk of CRC and CRAs. Conclusion: The results of this study demonstrated that adherence to a DASH dietary pattern could reduce the risk of CRC and CRA in men and women. Promoting a DASH eating plan can be helpful in reducing the risk of CRC.

KW - Adenomatous polyps

KW - Colorectal adenomas

KW - Colorectal cancer

KW - DASH score

KW - Diet quality indexes

KW - Dietary approaches to stop hypertension

KW - Dietary indexes

UR - http://www.scopus.com/inward/record.url?scp=85115614303&partnerID=8YFLogxK

U2 - 10.1186/s12885-021-08786-5

DO - 10.1186/s12885-021-08786-5

M3 - Article

AN - SCOPUS:85115614303

SN - 1471-2407

VL - 21

JO - BMC Cancer

JF - BMC Cancer

IS - 1

M1 - 1050

ER -

A case-control study of Dietary Approaches to Stop Hypertension (DASH) diets, colorectal cancer and adenomas among Iranian population

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this