A case-control study of Dietary Approaches to Stop Hypertension (DASH) diets, colorectal cancer and adenomas among Iranian population

Saeede Jafari Nasab, Matin Ghanavati, Pegah Rafiee, Alireza Bahrami, Nazanin Majidi, Cain C.T. Clark, Amir Sadeghi, Mohammad Houshyari, Ehsan Hejazi

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Abstract

Background and aims: Colorectal cancer (CRC) is the third most common cancer, worldwide. Recently, much attention has been given to the association between Dietary Approaches to Stop Hypertension (DASH) and CRC, however, data on colorectal adenomas (CRAs) as its precursor are scarce. Thus, the purpose of this case-control study was to investigate the association of DASH score with the risk of CRC and CRA in Iranian adults. Method: A total of 499 participants, including 129 CRC and 130 CRA cases, along with 240 controls, were asked about their dietary intake via a validated questionnaire. The DASH score was then calculated based on a priori methods and categorized in quartiles. Multivariate logistic regression was performed to assess the association of DASH score and the risk of CRC and CRA. Results: After adjusting for confounding variables, adherence to the DASH diet was associated with a reduction in the risk of CRC and CRA, respectively (OR of 4th versus 1st quartile = 0.04, 95% CI: 0.01–0.11, OR = 0.10, 95% CI: 0.04–0.22). Also, subgroup analysis based on gender showed that women and men with a higher DASH score had a significantly lower risk of CRC and CRAs. Conclusion: The results of this study demonstrated that adherence to a DASH dietary pattern could reduce the risk of CRC and CRA in men and women. Promoting a DASH eating plan can be helpful in reducing the risk of CRC.

Original languageEnglish
Article number1050
JournalBMC Cancer
Volume21
Issue number1
DOIs
Publication statusPublished - 25 Sep 2021

Bibliographical note

Funding Information:
The authors thank all study participants, without whom, the current study would have been impossible.

Publisher Copyright:
© 2021, The Author(s).

Keywords

  • Adenomatous polyps
  • Colorectal adenomas
  • Colorectal cancer
  • DASH score
  • Diet quality indexes
  • Dietary approaches to stop hypertension
  • Dietary indexes

ASJC Scopus subject areas

  • Oncology
  • Genetics
  • Cancer Research

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