Abstract
The invention relates to a preparation method of a water-based biological magnetic fluid, belonging to the technical field of biological materials. The preparation method comprises the following steps: dissolving ferric iron salt and water-soluble high polymers in diglycol, and heating and stirring the mixture for reaction in a nitrogen protection environment; then, rapidly injecting a diglycol monomethyl ether solution and continuously heating the mixture for reaction; and further adding acetone, adsorbing for separation by a magnet, and washing and dispersing the mixture in de-ionized water to obtain the water-based biological magnetic fluid. The water-soluble Fe3O4 magnetic nanometer particles prepared by the invention have good biological compatibility, narrow particle size distribution of the nanometer particles, good uniformity, high degree of crystallization and good controllability. The prepared water-based biological magnetic fluid has good stability and biological compatibility, and the magnetic response efficiency and the rheological characteristics of the biological magnetic fluid can be adjusted and controlled through the surface characteristics of the magnetic nanometer particles, which comprise the type, the structure and the coating rate of a coating material.
| Translated title of the contribution | Preparation method of water-based biological magnetic fluid |
|---|---|
| Original language | Chinese (Simplified) |
| Patent number | CN101719407A |
| IPC | A61K 47/00,B01F 3/12, H01F 1/44 |
| Priority date | 25/01/10 |
| Filing date | 25/01/10 |
| Publication status | Published - 2 Jun 2010 |
| Externally published | Yes |