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  • 382 Citations
  • 6 h-Index
20062018
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Personal profile

Research Interests

My laboratory studies the complex genetic and molecular mechanisms regulating cellular stress responses to identify potential new disease biomarkers and therapeutic targets. This includes identifying:

  • DNA damage response pathways that suppress cancer
  • Genes and mutations that influence radiotherapy and chemotherapy responses
  • How and why fasting alters cell health & cancer therapy effectiveness

We employ various complimentary model systems (yeast, flies, human cell culture and mice) and modern genetic, genomic, complex trait analysis, molecular biology, cell biology and CRISPR-Cas9 genome editing approaches.

Education/Academic qualification

Genetics, Doctorate, Newcastle University

… → 2007

Biomedical Science, Degree

19982002

External positions

Honorary Lecturer, University of Leicester

Sep 2018 → …

Fingerprint Dive into the research topics where Steven Foster is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 2 Similar Profiles
DNA Damage Medicine & Life Sciences
DNA Chemical Compounds
Repair Chemical Compounds
Yeast Chemical Compounds
Saccharomycetales Medicine & Life Sciences
Single-Stranded DNA Chemical Compounds
Telomere Medicine & Life Sciences
Cells Chemical Compounds

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Research Output 2006 2018

  • 382 Citations
  • 6 h-Index
  • 7 Article
  • 1 Chapter
4 Citations (Scopus)
10 Downloads (Pure)

MTH1 deficiency selectively increases non-cytotoxic oxidative DNA damage in lung cancer cells: more bad news than good?

Abbas, H., Alhamoudi, K., Evans, M., Jones, G. & Foster, S., 16 Apr 2018, In : BMC Cancer. 18, 423

Research output: Contribution to journalArticle

Open Access
File
lung neoplasms
DNA damage
DNA Damage
Lung Neoplasms
Cells
6 Downloads (Pure)

PHENOS: a high-throughput and flexible tool for microorganism growth phenotyping on solid media

Barton, D., Georghiou, D., Dave, N., Alghamdi, M., Walsh, T., Louis, E. & Foster, S., 24 Jan 2018, In : BMC Microbiology. 18, 9

Research output: Contribution to journalArticle

Open Access
File
Microorganisms
Throughput
Software
Quantitative Trait Loci
Growth
25 Citations (Scopus)
2 Downloads (Pure)

Cell cycle- and DNA repair pathway-specific effects of apoptosis on tumor suppression

Foster, S., De, S., Johnson, L. K., Petrini, J. H. J. & Stracker, T. H., 19 Jun 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 25, p. 9953-9958

Research output: Contribution to journalArticle

Open Access
File
DNA Repair
DNA Damage
Tumors
Cell Cycle
Carcinogenesis
62 Citations (Scopus)

Functional interplay of the Mre11 nuclease and Ku in the response to replication-associated DNA damage

Foster, S., Balestrini, A. & Petrini, J. H. J., Nov 2011, In : Molecular and Cellular Biology. 31, 21, p. 4379-4389 11 p.

Research output: Contribution to journalArticle

Camptothecin
DNA Damage
DNA Replication
DNA
Methyl Methanesulfonate
210 Citations (Scopus)
1 Downloads (Pure)

Histone deacetylase inhibitor induces DNA damage, which normal but not transformed cells can repair

Foster, S., Lee, J. H., Choy, M. L., Ngo, L. & Marks, P. A., 17 Aug 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 33, p. 14639-14644 6 p.

Research output: Contribution to journalArticle

Open Access
File
Histone Deacetylase Inhibitors
DNA Damage
Repair
DNA
Cell death