Sharon Williams

Dr

  • 348 Citations
  • 8 h-Index
20012019
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Personal profile

Biography

I have a PhD in Biochemistry. I worked as a post doctorate research fellow in both the Chemistry and the Biology departments of Warwick University between 2002 and 2010. My research focused on the biophysics and biochemistry of proteins, and understanding the mechanisms of enzymes. I have a wide range and depth of research experience in molecular biology, biochemistry, and chemistry.

I am member of the Royal Society of Chemistry and I am involved in many projects related to the society. I have joined Coventry University as a lecturer in November 2014 to continue my research into exploring enzymes mechanism in general and lignin degradation in particular.

Area of Expertise:

Biophysics and biochemistry of proteins, and understanding the mechanisms of enzymes.

Research Interests

Enzymes mechanisms and protein structure

Vision Statement

I am very interested in applications for industrial biotechnology that could be developed and characterize novel bioproducts obtained by enzymatic oxidation of lignin. In addition, lignin degradation would release valuable low molecular weight aromatic chemicals that would add considerable value to biofuel production.

My other interest is the twin-arginine translocation, or Tat pathway. In this pathway, substrates are synthesised with N-terminal signal peptides containing a key twin-arginine motif. The proteins are then transported by a membrane-bound Tat translocon which is uniquely able to transport fully folded proteins across the tightly coupled plasma membrane. One of the interests is how the system can be exploited for the production of high-value therapeutic proteins and also development of drug targets.

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

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Research Output 2001 2019

  • 348 Citations
  • 8 h-Index
  • 12 Article
  • 1 Commissioned report
  • 1 Review article

Higher Education Outreach: Examining Key Challenges For Academics

Johnson, M., Danvers, E., Hinton-Smith, T., Atkinson, K., Bowden, G., Foster, J., Garner, K., Garrud, P., Greaves, S., Harris, P., Hejmadi, M., Hill, D., Hughes, G., Jackson, L., O'Sullivan, A., O'Tuama, S., Brown, P. P., Philipson, P., Ravenscroft, S., Rhys, M. & 6 othersRitchie, T., Talbot, J., Walker, D., Watson, J., Williams, M. & Williams, S., 4 Feb 2019, In : British journal of educational studies. (In-Press), p. (In-Press)

Research output: Contribution to journalArticle

education
tuition fee
impact research
participation
university

Protein engineering of Pseudomonas fluorescens peroxidase Dyp1B for oxidation of phenolic and polymeric lignin substrates

Pour, R. R., Ehibhatiomhan, A., Huang, Y., Ashley, B., Rashid, G., Mendel Williams, S. & Bugg, T. D. H., Apr 2019, In : Enzyme and Microbial Technology. 123, p. 21-29 9 p.

Research output: Contribution to journalArticle

protein engineering
Pseudomonas fluorescens
lignin
peroxidase
oxidation

Association for Academic Outreach Evidence Submission to the UPP Foundation Civic University Commission 2018 Association for Academic Outreach

Williams, S., Talbot, J., Awesti, A., Bowden, G., Danvers, E., Foster, J. M., Hejmadi, M., Hinton-Smith, T., Lazarus, J., Melhuish, C., Moffat, C. R., O'Tuama, S., Walker, D., Watson, J. & Harris, N., 31 Jul 2018

Research output: Book/ReportCommissioned report

8 Citations (Scopus)

Expression of the bifunctional Bacillus subtilis TatAd protein in Escherichia coli reveals distinct TatA/B-family and TatB-specific domains

Barnett, J. P., Lawrence, J., Mendel, S. & Robinson, C., Aug 2011, In : Archives of Microbiology. 193, 8, p. 583-594 12 p.

Research output: Contribution to journalArticle

Escherichia coli Proteins
Bacilli
Bacillus subtilis
Escherichia coli
Gram-Negative Bacteria
68 Citations (Scopus)

Transport and proofreading of proteins by the twin-arginine translocation (Tat) system in bacteria

Robinson, C., Matos, C. F. R. O., Beck, D., Ren, C., Lawrence, J., Vasisht, N. & Mendel, S., Mar 2011, In : Biochimica et biophysica acta. 1808, 3, p. 876-884 9 p.

Research output: Contribution to journalArticle

Carrier Proteins
Bacteria
Protein Transport
Proteins
Cell Membrane

Activities 2016 2019

  • 12 Public Engagement Event
  • 1 Participation in conference
  • 1 Invited talk
  • 1 Oral presentation

Introduction to the cell components and DNA fun activity for the family

Sharon Williams (Organiser)
22 Feb 201923 Feb 2019

Activity: Participating in or organising an eventPublic Engagement Event

Chemistry for all

Sharon Williams (Organiser)
18 Jan 20196 Apr 2019

Activity: Participating in or organising an eventPublic Engagement Event

Chemistry for all

Sharon Williams (Organiser)
29 Jun 201830 Jun 2018

Activity: Participating in or organising an eventPublic Engagement Event

Chemistry week

Sharon Williams (Organiser)
23 Nov 201824 Nov 2018

Activity: Participating in or organising an eventPublic Engagement Event

Chemistry for all

Sharon Williams (Organiser)
18 May 201819 May 2018

Activity: Participating in or organising an eventPublic Engagement Event

Prizes

Coventry Excellence Awards

Igor Morozov (Recipient), Sharon Williams (Recipient), Jess Rollason (Recipient), Lauren Acton (Recipient) & Martin Cox (Recipient), 15 Jun 2015

Prize: Prize (including medals and awards)

Press / Media

Chemistry for all at the FabLab

Sharon Williams

18/06/18

1 media contribution

Press/Media: Public Engagement Activities

Chemistry week

Sharon Williams

30/11/17

1 media contribution

Press/Media: Public Engagement Activities

Introduction to DNA’ for primary pupils

Sharon Williams

16/08/17

1 media contribution

Press/Media: Public Engagement Activities