Sebastien Farnaud

Dr, BSc, MSc, PGCert, fHEA, FRSB, FIBMS

Accepting PhD Students

  • 1099 Citations
  • 15 h-Index
1994 …2021
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Research Output 1994 2019

  • 1099 Citations
  • 15 h-Index
  • 26 Article
  • 7 Review article
  • 1 Chapter
  • 1 Comment/debate
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Article
1994
40 Citations (Scopus)

Expression of hepatocyte growth factor mRNA, and c-met mRNA (hepatocyte growth factor receptor) in human liver tumours

Selden, C., Farnaud, S., Ding, S. F., Habib, N., Foster, C. & Hodgson, H. J. F., 1994, In : Journal of Hepatology. 21, 2, p. 227-234 8 p.

Research output: Contribution to journalArticle

Proto-Oncogene Proteins c-met
Hepatocyte Growth Factor
Liver Neoplasms
Messenger RNA
Liver
25 Citations (Scopus)

Hepatocyte growth factor (HGF/SF) is expressed in human epithelial cells during embryonic development; Studies by in situ hybridisation and Northern blot analysis

Wang, Y., Selden, C., Farnaud, S., Calnan, D. & Hodgson, H. J. F., 1994, In : Journal of Anatomy. 185, 3, p. 543-551 9 p.

Research output: Contribution to journalArticle

hepatocyte growth factor
Hepatocyte Growth Factor
embryonic development
Northern blotting
Northern Blotting
1999
19 Citations (Scopus)

Evidence that cysteine-166 is the active-site nucleophile of Pseudomonas aeruginosa amidase: Crystallization and preliminary X-ray diffraction analysis of the enzyme

Farnaud, S., Tata, R., Sohi, M. K., Wan, T., Brown, P. R. & Sutton, B. J., 15 Jun 1999, In : Biochemical Journal. 340, 3, p. 711-714 4 p.

Research output: Contribution to journalArticle

amidase
Amidohydrolases
Nucleophiles
Crystallization
X-Ray Diffraction
2000
6 Citations (Scopus)

Differential behaviour of recombinant wild-type and altered amidases on immobilized metal-ion affinity chromatography

Martins, S., Farnaud, S., Pacheco, V., Pacheco, R., Karmali, A., Tata, R. & Brown, P. R., 2000, In : International Journal of Bio-Chromatography. 5, 2, p. 111-129 19 p.

Research output: Contribution to journalArticle

amidase
Amidohydrolases
Affinity chromatography
Ion chromatography
Affinity Chromatography
2002
38 Citations (Scopus)
amidase
nitrilase
Mutagenesis
Substrate Specificity
Site-Directed Mutagenesis
2004
66 Citations (Scopus)

Interactions of lactoferricin-derived peptides with LPS and antimicrobial activity

Farnaud, S., Spiller, C., Moriarty, L. C., Patel, A., Gant, V., Odell, E. W. & Evans, R. W., 1 Apr 2004, In : FEMS Microbiology Letters. 233, 2, p. 193-199 7 p.

Research output: Contribution to journalArticle

Peptides
Lipid A
Tryptophan
Hydrophobic and Hydrophilic Interactions
Population Groups
15 Citations (Scopus)

The plug domain of a neisserial TonB-dependent transporter retains structural integrity in the absence of its transmembrane β-barrel

Oke, M., Sarra, R., Ghirlando, R., Farnaud, S., Gorringe, A. R., Evans, R. W. & Buchanan, S. K., 30 Apr 2004, In : FEBS Letters. 564, 3, p. 294-300 7 p.

Research output: Contribution to journalArticle

Transferrin-Binding Protein A
Structural integrity
Transferrin
Periplasm
Calorimetry
14 Citations (Scopus)

Variation in antimicrobial activity of lactoferricin-derived peptides explained by structure modelling

Farnaud, S., Patel, A., Odell, E. W. & Evans, R. W., 1 Sep 2004, In : FEMS Microbiology Letters. 238, 1, p. 221-226 6 p.

Research output: Contribution to journalArticle

Lactoferrin
Peptides
lactoferricin B
Membranes
Sequence Alignment
2006
13 Citations (Scopus)

Characterisation of recombinant unglycosylated human serum transferrin purified from Saccharomyces cerevisiae

Sargent, P. J., Farnaud, S., Cammack, R., Zoller, H. M. P. & Evans, R. W., Oct 2006, In : BioMetals. 19, 5, p. 513-519 7 p.

Research output: Contribution to journalArticle

transferrin
Transferrin
Yeast
Saccharomyces cerevisiae
Recombinant proteins
24 Citations (Scopus)

Modelling of a metal-containing hepcidin

Farnaud, S., Patel, A. & Evans, R. W., Oct 2006, In : BioMetals. 19, 5, p. 527-533 7 p.

Research output: Contribution to journalArticle

Hepcidins
Peptides
Metals
metals
iron
2008
7 Citations (Scopus)

Biochemical and spectroscopic studies of human melanotransferrin (MTf): Electron-paramagnetic resonance evidence for a difference between the iron-binding site of MTf and other transferrins

Farnaud, S., Amini, M., Rapisarda, C., Cammack, R., Bui, T., Drake, A., Evans, R. W., Rahmanto, Y. S. & Richardson, D. R., 2008, In : International Journal of Biochemistry and Cell Biology. 40, 12, p. 2739-2745 7 p.

Research output: Contribution to journalArticle

Transferrins
Electron Spin Resonance Spectroscopy
Paramagnetic resonance
Transferrin
Iron
24 Citations (Scopus)

Identification of an iron-hepcidin complex

Farnaud, S., Rapisarda, C., Bui, T., Drake, A., Cammack, R. & Evans, R. W., 1 Aug 2008, In : Biochemical Journal. 413, 3, p. 553-557 5 p.

Research output: Contribution to journalArticle

Hepcidins
Iron
Sulfur
Peptides
Rubredoxins
92 Citations (Scopus)

Isolation of lactoferrin from milk of different species: Calorimetric and antimicrobial studies

Conesa, C., Sánchez, L., Rota, C., Pérez, M. D., Calvo, M., Farnaud, S. & Evans, R. W., May 2008, In : Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology. 150, 1, p. 131-139 9 p.

Research output: Contribution to journalArticle

Lactoferrin
Milk
Earless Seals
New World Camelids
Iron
28 Citations (Scopus)

The interaction of arginine- and tryptophan-rich cyclic hexapeptides with Escherichia coli membranes

Junkes, C., Wessolowski, A., Farnaud, S., Evans, R. W., Good, L., Bienet, M. & Dathe, M., Apr 2008, In : Journal of Peptide Science. 14, 4, p. 535-543 9 p.

Research output: Contribution to journalArticle

Tryptophan
Escherichia coli
Arginine
Membranes
Peptides
2009
11 Citations (Scopus)

An overview of molecular aspects of iron metabolism

Syed, B. A., Sargent, P. J., Farnaud, S. & Evans, R. W., 7 Jul 2009, In : Hemoglobin. 30, 1, p. 69-80 12 p.

Research output: Contribution to journalArticle

Metabolism
Iron
Cloning
Poisons
Organism Cloning

The Dr Hadwen Trust for Humane Research: 39 years of replacement science

Farnaud, S., Dec 2009, In : Alternatives to Laboratory Animals. 37, SUPPL. 2, p. 39-43 5 p.

Research output: Contribution to journalArticle

Anniversaries and Special Events
Animals
Research
Publications
Motivation
2010

Microdosing: Safer clinical trials and fewer animal tests

Langley, G. & Farnaud, S., Mar 2010, In : Bioanalysis. 2, 3, p. 393-395 3 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Transferrin receptor 2 is crucial for iron sensing in human hepatocytes

Rapisarda, C., Puppi, J., Hughes, R. D., Dhawan, A., Farnaud, S., Evans, R. W. & Sharp, P. A., 1 Sep 2010, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 299, 3

Research output: Contribution to journalArticle

Hepcidins
Transferrin Receptors
Hepatocytes
Iron
Hepatocellular Carcinoma
2013
26 Citations (Scopus)

A novel approach to oral iron delivery using ferrous sulphate loaded solid lipid nanoparticles

Zariwala, M. G., Elsaid, N., Jackson, T. L., Corral López, F., Farnaud, S., Somavarapu, S. & Renshaw, D., 18 Nov 2013, In : Scientia Pharmaceutica. 456, 2, p. 400-7 8 p.

Research output: Contribution to journalArticle

ferrous sulfate
Nanoparticles
Iron
Lipids
Chitosan
16 Citations (Scopus)

Comparison study of oral iron preparations using a human intestinal model

Zariwala, M. G., Somavarapu, S., Farnaud, S. & Renshaw, D., 21 Jun 2013, In : Scientia Pharmaceutica. 81, 4, p. 1123-39 17 p.

Research output: Contribution to journalArticle

Iron
ferrous sulfate
Tablets
Nutrition Disorders
Caco-2 Cells
2014
8 Citations (Scopus)

Ascorbyl palmitate/DSPE-PEG nanocarriers for oral iron delivery: Preparation, characterisation and in vitro evaluation

Zariwala, M. G., Farnaud, S., Merchant, Z., Somavarapu, S. & Renshaw, D., 1 Mar 2014, In : Colloids and surfaces. B, Biointerfaces. 115, p. 86-92 7 p.

Research output: Contribution to journalArticle

Ascorbyl palmitate
Polyethylene glycols
glycols
polyethylenes
delivery
2015
1 Citation (Scopus)

Characterisation of hepcidin response to holotransferrin treatment in CHO TRVb-1 cells

Mehta, K., Greenwell, P., Renshaw, D., Busbridge, M., Garcia, M., Farnaud, S. & Patel, V. B., Aug 2015, In : Blood Cells, Molecules, and Diseases. 55, 2, p. 110–118 9 p.

Research output: Contribution to journalArticle

Hepcidins
Hep G2 Cells
Iron
Messenger RNA
Transferrin Receptors
2016
1 Citation (Scopus)
23 Downloads (Pure)

Characterization of hepcidin response to holotransferrin in novel recombinant TfR1 HepG2 cells

Mehta, K., Busbridge, M., Renshaw, D., Evans, R. W., Farnaud, S. & Patel, V. B., Oct 2016, In : Blood Cells, Molecules, and Diseases. 61, p. 37-45 9 p.

Research output: Contribution to journalArticle

Open Access
File
Hepcidins
Hep G2 Cells
Iron
holotransferrin
Messenger RNA
2017
12 Downloads (Pure)

HFE mRNA expression is responsive to intracellular and extracellular iron loading: short communication

Mehta, K. J., Farnaud, S. & Patel, V. B., 19 Sep 2017, In : Molecular Biology Reports. 44, 5, p. 399-403 5 p.

Research output: Contribution to journalArticle

Open Access
File
Iron
Messenger RNA
Hepcidins
Hepatocytes
Ferrozine
2018
4 Citations (Scopus)
22 Downloads (Pure)

Hydrophobically-modified chitosan nanoliposomes for intestinal drug delivery

Zariwala, M. G., Bendre, H., Markiv, A., Farnaud, S., Renshaw, D., Taylor, K. M. G. & Somavarapu, S., 27 Sep 2018, In : International Journal of Nanomedicine. 13, p. 5837-5848 12 p.

Research output: Contribution to journalArticle

Open Access
File
Chitosan
Liposomes
Pharmaceutical Preparations
ferrous sulfate
Iron
2019
10 Downloads (Pure)

A Novel Human Neuronal Cell Model to Study Iron Accumulation in Parkinson’s Disease

Mehta, K., Ahmed, B. Y. & Farnaud, S., 11 Feb 2019, In : Journal of Alzheimer's Disease and Parkinsonism . 9, 1, 5 p., 1000461.

Research output: Contribution to journalArticle

Open Access
File
Parkinson Disease
Iron
Dopaminergic Neurons
Parkinsonian Disorders
Ferrozine