Sebastien Farnaud &ndash; Research Output

2019

A Novel Human Neuronal Cell Model to Study Iron Accumulation in Parkinson’s Disease

Mehta, K., Ahmed, B. Y. & Farnaud, S., 11 Feb 2019, In : Journal of Alzheimer's Disease and Parkinsonism . 9, 1, 5 p., 1000461.

Research output: Contribution to journal › Article

Open Access

File

Parkinson Disease

Iron

Dopaminergic Neurons

Parkinsonian Disorders

Ferrozine

2018

1 Citation (Scopus)

17 Downloads (Pure)

Hydrophobically-modified chitosan nanoliposomes for intestinal drug delivery

Zariwala, M. G., Bendre, H., Markiv, A., Farnaud, S., Renshaw, D., Taylor, K. M. G. & Somavarapu, S., 27 Sep 2018, In : International Journal of Nanomedicine. 13, p. 5837-5848 12 p.

Research output: Contribution to journal › Article

Open Access

File

Chitosan

Liposomes

Pharmaceutical Preparations

ferrous sulfate

Iron

2017

4 Downloads (Pure)

HFE mRNA expression is responsive to intracellular and extracellular iron loading: short communication

Mehta, K. J., Farnaud, S. & Patel, V. B., 19 Sep 2017, In : Molecular Biology Reports. 44, 5, p. 399-403 5 p.

Research output: Contribution to journal › Article

Open Access

File

Iron

Messenger RNA

Hepcidins

Hepatocytes

Ferrozine

2016

1 Citation (Scopus)

20 Downloads (Pure)

Characterization of hepcidin response to holotransferrin in novel recombinant TfR1 HepG2 cells

Mehta, K., Busbridge, M., Renshaw, D., Evans, R. W., Farnaud, S. & Patel, V. B., Oct 2016, In : Blood Cells, Molecules, and Diseases. 61, p. 37-45 9 p.

Research output: Contribution to journal › Article

Open Access

File

Hepcidins

Hep G2 Cells

Iron

holotransferrin

Messenger RNA

2015

1 Citation (Scopus)

Characterisation of hepcidin response to holotransferrin treatment in CHO TRVb-1 cells

Mehta, K., Greenwell, P., Renshaw, D., Busbridge, M., Garcia, M., Farnaud, S. & Patel, V. B., Aug 2015, In : Blood Cells, Molecules, and Diseases. 55, 2, p. 110–118 9 p.

Research output: Contribution to journal › Article

Hepcidins

Hep G2 Cells

Iron

Messenger RNA

Transferrin Receptors

2014

4 Citations (Scopus)

Ascorbyl palmitate/DSPE-PEG nanocarriers for oral iron delivery: Preparation, characterisation and in vitro evaluation

Zariwala, M. G., Farnaud, S., Merchant, Z., Somavarapu, S. & Renshaw, D., 1 Mar 2014, In : Colloids and surfaces. B, Biointerfaces. 115, p. 86-92 7 p.

Research output: Contribution to journal › Article

Ascorbyl palmitate

Polyethylene glycols

glycols

polyethylenes

delivery

2013

17 Citations (Scopus)

A novel approach to oral iron delivery using ferrous sulphate loaded solid lipid nanoparticles

Zariwala, M. G., Elsaid, N., Jackson, T. L., Corral López, F., Farnaud, S., Somavarapu, S. & Renshaw, D., 18 Nov 2013, In : Scientia Pharmaceutica. 456, 2, p. 400-7 8 p.

Research output: Contribution to journal › Article

ferrous sulfate

Nanoparticles

Iron

Lipids

Chitosan

12 Citations (Scopus)

Comparison study of oral iron preparations using a human intestinal model

Zariwala, M. G., Somavarapu, S., Farnaud, S. & Renshaw, D., 21 Jun 2013, In : Scientia Pharmaceutica. 81, 4, p. 1123-39 17 p.

Research output: Contribution to journal › Article

Iron

ferrous sulfate

Tablets

Nutrition Disorders

Caco-2 Cells

2010

Microdosing: Safer clinical trials and fewer animal tests

Langley, G. & Farnaud, S., Mar 2010, In : Bioanalysis. 2, 3, p. 393-395 3 p.

Research output: Contribution to journal › Article

14 Citations (Scopus)

Transferrin receptor 2 is crucial for iron sensing in human hepatocytes

Rapisarda, C., Puppi, J., Hughes, R. D., Dhawan, A., Farnaud, S., Evans, R. W. & Sharp, P. A., 1 Sep 2010, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 299, 3

Research output: Contribution to journal › Article

Hepcidins

Transferrin Receptors

Hepatocytes

Iron

Hepatocellular Carcinoma

2009

11 Citations (Scopus)

An overview of molecular aspects of iron metabolism

Syed, B. A., Sargent, P. J., Farnaud, S. & Evans, R. W., 7 Jul 2009, In : Hemoglobin. 30, 1, p. 69-80 12 p.

Research output: Contribution to journal › Article

Metabolism

Iron

Cloning

Poisons

Organism Cloning

The Dr Hadwen Trust for Humane Research: 39 years of replacement science

Farnaud, S., Dec 2009, In : Alternatives to Laboratory Animals. 37, SUPPL. 2, p. 39-43 5 p.

Research output: Contribution to journal › Article

Anniversaries and Special Events

Animals

Research

Publications

Motivation

2008

5 Citations (Scopus)

Biochemical and spectroscopic studies of human melanotransferrin (MTf): Electron-paramagnetic resonance evidence for a difference between the iron-binding site of MTf and other transferrins

Farnaud, S., Amini, M., Rapisarda, C., Cammack, R., Bui, T., Drake, A., Evans, R. W., Rahmanto, Y. S. & Richardson, D. R., 2008, In : International Journal of Biochemistry and Cell Biology. 40, 12, p. 2739-2745 7 p.

Research output: Contribution to journal › Article

Transferrins

Electron Spin Resonance Spectroscopy

Paramagnetic resonance

Transferrin

Iron

23 Citations (Scopus)

Identification of an iron-hepcidin complex

Farnaud, S., Rapisarda, C., Bui, T., Drake, A., Cammack, R. & Evans, R. W., 1 Aug 2008, In : Biochemical Journal. 413, 3, p. 553-557 5 p.

Research output: Contribution to journal › Article

Hepcidins

Iron

Sulfur

Peptides

Rubredoxins

86 Citations (Scopus)

Isolation of lactoferrin from milk of different species: Calorimetric and antimicrobial studies

Conesa, C., Sánchez, L., Rota, C., Pérez, M. D., Calvo, M., Farnaud, S. & Evans, R. W., May 2008, In : Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology. 150, 1, p. 131-139 9 p.

Research output: Contribution to journal › Article

Lactoferrin

Milk

Earless Seals

New World Camelids

Iron

27 Citations (Scopus)

The interaction of arginine- and tryptophan-rich cyclic hexapeptides with Escherichia coli membranes

Junkes, C., Wessolowski, A., Farnaud, S., Evans, R. W., Good, L., Bienet, M. & Dathe, M., Apr 2008, In : Journal of Peptide Science. 14, 4, p. 535-543 9 p.

Research output: Contribution to journal › Article

Tryptophan

Escherichia coli

Arginine

Membranes

Peptides

2006

12 Citations (Scopus)

Characterisation of recombinant unglycosylated human serum transferrin purified from Saccharomyces cerevisiae

Sargent, P. J., Farnaud, S., Cammack, R., Zoller, H. M. P. & Evans, R. W., Oct 2006, In : BioMetals. 19, 5, p. 513-519 7 p.

Research output: Contribution to journal › Article

transferrin

Transferrin

Yeast

Saccharomyces cerevisiae

Recombinant proteins

23 Citations (Scopus)

Modelling of a metal-containing hepcidin

Farnaud, S., Patel, A. & Evans, R. W., Oct 2006, In : BioMetals. 19, 5, p. 527-533 7 p.

Research output: Contribution to journal › Article

Hepcidins

Peptides

Metals

metals

iron

2004

65 Citations (Scopus)

Interactions of lactoferricin-derived peptides with LPS and antimicrobial activity

Farnaud, S., Spiller, C., Moriarty, L. C., Patel, A., Gant, V., Odell, E. W. & Evans, R. W., 1 Apr 2004, In : FEMS Microbiology Letters. 233, 2, p. 193-199 7 p.

Research output: Contribution to journal › Article

Peptides

Lipid A

Tryptophan

Hydrophobic and Hydrophilic Interactions

Population Groups

15 Citations (Scopus)

The plug domain of a neisserial TonB-dependent transporter retains structural integrity in the absence of its transmembrane β-barrel

Oke, M., Sarra, R., Ghirlando, R., Farnaud, S., Gorringe, A. R., Evans, R. W. & Buchanan, S. K., 30 Apr 2004, In : FEBS Letters. 564, 3, p. 294-300 7 p.

Research output: Contribution to journal › Article

Transferrin-Binding Protein A

Structural integrity

Transferrin

Periplasm

Calorimetry

14 Citations (Scopus)

Variation in antimicrobial activity of lactoferricin-derived peptides explained by structure modelling

Farnaud, S., Patel, A., Odell, E. W. & Evans, R. W., 1 Sep 2004, In : FEMS Microbiology Letters. 238, 1, p. 221-226 6 p.

Research output: Contribution to journal › Article

Lactoferrin

Peptides

lactoferricin B

Membranes

Sequence Alignment

2002

37 Citations (Scopus)

Support for a three-dimensional structure predicting a Cys-Glu-Lys catalytic triad for Pseudomonas aeruginosa amidase comes from site-directed mutagenesis and mutations altering substrate specificity

Novo, C., Farnaud, S., Tata, R., Clemente, A. & Brown, P. R., 1 Aug 2002, In : Biochemical Journal. 365, 3, p. 731-738 8 p.

Research output: Contribution to journal › Article

amidase

nitrilase

Mutagenesis

Substrate Specificity

Site-Directed Mutagenesis

2000

6 Citations (Scopus)

Differential behaviour of recombinant wild-type and altered amidases on immobilized metal-ion affinity chromatography

Martins, S., Farnaud, S., Pacheco, V., Pacheco, R., Karmali, A., Tata, R. & Brown, P. R., 2000, In : International Journal of Bio-Chromatography. 5, 2, p. 111-129 19 p.

Research output: Contribution to journal › Article

amidase

Amidohydrolases

Affinity chromatography

Ion chromatography

Affinity Chromatography

1999

19 Citations (Scopus)

Evidence that cysteine-166 is the active-site nucleophile of Pseudomonas aeruginosa amidase: Crystallization and preliminary X-ray diffraction analysis of the enzyme

Farnaud, S., Tata, R., Sohi, M. K., Wan, T., Brown, P. R. & Sutton, B. J., 15 Jun 1999, In : Biochemical Journal. 340, 3, p. 711-714 4 p.

Research output: Contribution to journal › Article

amidase

Amidohydrolases

Nucleophiles

Crystallization

X-Ray Diffraction

1994

40 Citations (Scopus)

Expression of hepatocyte growth factor mRNA, and c-met mRNA (hepatocyte growth factor receptor) in human liver tumours

Selden, C., Farnaud, S., Ding, S. F., Habib, N., Foster, C. & Hodgson, H. J. F., 1994, In : Journal of Hepatology. 21, 2, p. 227-234 8 p.

Research output: Contribution to journal › Article

Proto-Oncogene Proteins c-met

Hepatocyte Growth Factor

Liver Neoplasms

Messenger RNA

Liver

24 Citations (Scopus)

Hepatocyte growth factor (HGF/SF) is expressed in human epithelial cells during embryonic development; Studies by in situ hybridisation and Northern blot analysis

Wang, Y., Selden, C., Farnaud, S., Calnan, D. & Hodgson, H. J. F., 1994, In : Journal of Anatomy. 185, 3, p. 543-551 9 p.

Research output: Contribution to journal › Article

hepatocyte growth factor

Hepatocyte Growth Factor

embryonic development

Northern blotting

Northern Blotting