Projects per year
Personal profile
Biography
Michael is a biochemist who studied Biochemistry at Bath University, during this time he spent time at the University of Michigan (USA) and Duke University (USA) for six-month placements. After his studies, he worked for a year as a formulations technician at the vaccine company: PowderMed in Oxford. He returned to his studies for a DPhil (PhD) in the Department of Cardiovascular Medicine and the Department of Physiology, Anatomy, and Genetics (DPAG) at the University of Oxford. His PhD work was on the application of novel magnetic resonance imaging and spectroscopy tools to better characterize metabolic alterations that occur during heart disease. Developing this further, he undertook a 2-year post-doc sponsored by the British Heart Foundation (BHF) to investigate the translation of his PhD work into human volunteers in the Oxford Centre for Clinical Magnetic Resonance Research. In 2014, Michael was awarded a Novo Nordisk Fellowship, to investigate the effects of fatty acids on the heart's ability to adapt to hypoxia. In 2018, Michael moved to Coventry University to continue his research into cellular adaptation to hypoxia during Diabetes. This includes how diabetic kidney cells respond to hypoxia and if GLP1 agonists can rescue cells.
Michael's research involves examining the metabolism of the failing and diseased heart. The healthy heart derives 60-80% of its energy from the burning of fat, the rest from carbohydrates and ketones. During heart disease, this carefully balanced use of fuel can become breakdown. Understanding why this is the case and how to prevent the deterioration of this metabolic balance may provide clues on how to better treat heart disease. Michael’s current research is supported by a Diabetes UK Early Career Small Research Grant.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
DPhil, Doctorate, The Development and Application of New Hyperpolarized MRS Techniques for the Non-Invasive Assessment of Metabolism in the Rodent Heart, University of Oxford
1 Oct 2008 → 30 Sept 2012
Award Date: 22 Sept 2012
Biochemistry, MSc, University of Bath
1 Sept 2003 → 21 Jul 2007
Award Date: 21 Jul 2007
External positions
Committee Member: Education, Training and Outreach, Biochemical Society
1 Jan 2019 → …
Early Career Panel Member, Biochemical Society
1 Jan 2019 → …
Novo Nordisk Postdoctoral Fellow, University of Oxford
1 Oct 2014 → 31 Mar 2018
BHF Postdoctoral Researcher, University of Oxford
1 Oct 2012 → 30 Sept 2014
Keywords
- QP Physiology
- Metabolism
- Heart
- MRI
- Hypoxia
- Diabetes
- 3D Cell culture
- QH301 Biology
- Metabolism
- QM Human anatomy
- Heart
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Collaborations and top research areas from the last five years
Projects
- 1 Finished
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Oncometabolite regulation of the PHD3/CPT1B/VDAC1 axis in diabetic cardiomyocytes
1/09/22 → 31/08/23
Project: Research
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Metabolism
Judge, A. & Dodd, M. S., 8 Oct 2020, In: Essays in Biochemistry. 64, 4, p. 607-647 41 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile129 Citations (Scopus)386 Downloads (Pure) -
Fatty acids prevent Hypoxia-Inducible Factor 1α signalling in type 2 diabetes
Dodd, M., Sousa Fialho, M. D. L., Montes Aparico, C. N., Kerr, M., Timm, K. N., Griffin, J. L., Luiken, J. J. F. P., Glatz, J. F. C., Tyler, D. J. & Heather, L. C., Aug 2018, In: Journal of the American College of Cardiology: Basic to Translational Science. 3, 4, p. 485-498 14 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile53 Citations (Scopus)113 Downloads (Pure) -
Haematological and biochemical pathology markers for a predictive model for ITU admission and death from COVID‐19: A retrospective study
Rasarathnam, A., Haynes‐Smith, T., Wassif, W. S. & Dodd, M. S., 12 Jul 2022, (E-pub ahead of print) In: eJHaem. 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile27 Downloads (Pure) -
GLP-1 receptor agonists offer protection against fatty acid induced insulin resistance in 3D kidney spheroids.
Judge, A., Thakore, J. & Dodd, M., Nov 2021.Research output: Contribution to conference › Poster
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Early detection of doxorubicin-induced cardiotoxicity in rats by its cardiac metabolic signature assessed with hyperpolarized MRI
Timm, K., Perera, C., Ball, V., Henry, J., Miller, J., Kerr, M., West, J., Sharma, E., Broxholme, J., Logan, A., Savic, D., Dodd, M., Griffin, J. L., Murphy, M., Heather, L. C. & Tyler, D. J., 19 Nov 2020, In: Communications Biology. 3, 10 p., 692 .Research output: Contribution to journal › Article › peer-review
Open AccessFile24 Citations (Scopus)21 Downloads (Pure)
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Biochemical Society (External organisation)
Mike Dodd (Member)
2023 → …Activity: Membership › Membership of committee
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Journal of Cardiovascular Magnetic Resonance (Journal)
Mike Dodd (Peer Reviewer)
May 2018Activity: Publication peer-review and editorial work › Publication peer-review
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Journal of Cardiovascular Magnetic Resonance (Journal)
Mike Dodd (Peer Reviewer)
Jul 2018Activity: Publication peer-review and editorial work › Publication peer-review
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Acta Diabetologica (Journal)
Mike Dodd (Peer Reviewer)
Jun 2018Activity: Publication peer-review and editorial work › Publication peer-review
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Acta Diabetologica (Journal)
Mike Dodd (Advisory Board Member)
2018 → …Activity: Publication peer-review and editorial work › Editorial activity