Mike Dodd

Assistant Professor, School of Life Sciences
Associate, Faculty Research Centre for Sport, Exercise and Life Sciences

https://orcid.org/0000-0002-1217-4660

Emailac8844@coventry.ac.uk

Accepting PhD Students

800 Citations
14 h-Index

Research output per year

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Personal profile

Biography

Michael is a biochemist who studied Biochemistry at Bath University, during this time he spent time at the University of Michigan (USA) and Duke University (USA) for six-month placements. After his studies he worked for a year as a formulations technician at the vaccine company: PowderMed in Oxford. He returned to his studies for a DPhil (PhD) in the Department of Cardiovascular Medicine and the Department of Physiology, Anatomy and Genetics (DPAG) at the University of Oxford. His PhD work was on the application of novel magnetic resonance imaging and spectroscopy tools to better characterize metabolic alterations that occur during heart disease. Developing this further, he undertook a 2 year post-doc sponsored by the British Heart Foundation (BHF) to investigate the translation of his PhD work into human volunteers in the Oxford Centre for Clinical Magnetic Resonance Research. In 2014, Michael was awarded a Novo Nordisk Fellowship, to investigate the effects of fatty acids on the hearts ability to adapt to hypoxia.

Michael's research involves examining the metabolism of the failing and diseased heart. The healthy heart derives 60-80% of its energy from the burning of fat, the rest from carbohydrates and ketones. During heart disease this carefully balanced use of fuel can become breakdown. Understanding why this is the case and how to prevent the deterioration of this metabolic balance may provide clues on how to better treat heart disease.

Education/Academic qualification

DPhil, Doctorate, University of Oxford

1 Oct 2008 → 30 Sep 2012

Biochemistry, MSc, University of Bath

1 Sep 2003 → 21 Jul 2007

External positions

Novo Nordisk Postdoctoral Fellow, University of Oxford

1 Oct 2014 → 31 Mar 2018

BHF Postdoctoral Researcher, University of Oxford

1 Oct 2012 → 30 Sep 2014

Keywords

QP Physiology
Metabolism
Heart
MRI
Hypoxia
Diabetes
QH301 Biology
Metabolism
QM Human anatomy
Heart

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Research Output

800 Citations
14 h-Index
21 Article
1 Short survey
1 Review article

Non-Invasive In Vivo Assessment of Cardiac Metabolism in the Healthy and Diabetic Human Heart Using Hyperpolarized 13C MRI

Rider, O., Apps, A., Miller, J., Lau, J., Lewis, A., Peterzan, M., Dodd, M., Lau, A., Trumper, C., Gallagher, F., Grist, J., Brindle, K., Neubauer, S. & Tyler, D. J., 13 Mar 2020, In : Circulation Research. 126, 6, p. 725-736 12 p.

Research output: Contribution to journal › Article

Open Access

File

1 Citation (Scopus)

3 Downloads (Pure)

Assessing the optimal preparation strategy to minimize the variability of cardiac pyruvate dehydrogenase flux measurements with hyperpolarized MRS

Timm, K. N., Apps, A., Miller, J. J., Ball, V., Chong, C-R., Dodd, M. & Tyler, D. J., Sep 2018, In : NMR in Biomedicine. 31, 9, 8 p., e3992.

Research output: Contribution to journal › Article

Open Access

File

13 Downloads (Pure)

Bernard and Joan Marshall Awards at the autumn meeting of the British Society for Cardiovascular Research 2017

Carr, C. A., Dodd, M. S. & Heather, L. C., 20 Jun 2018, In : Heart. 104, 16

Research output: Contribution to journal › Short survey

CPT1a-dependent long-chain fatty acid oxidation is essential for maintaining glucagon secretion from pancreatic islets

Briant, L. J. B., Dodd, M., Chibalina, M. V., Rorseman, N. J. G., Carmeliet, P., Johnson, P. R. J., Rorsman, P. & Knudsen, J. G., 12 Jun 2018, In : Cell Reports. 23, 11, p. 3300-3311 12 p.

Research output: Contribution to journal › Article

Open Access

File

14 Citations (Scopus)

52 Downloads (Pure)

Fatty acids prevent Hypoxia-Inducible Factor 1α signalling in type 2 diabetes

Dodd, M., Sousa Fialho, M. D. L., Montes Aparico, C. N., Kerr, M., Timm, K. N., Griffin, J. L., Luiken, J. J. F. P., Glatz, J. F. C., Tyler, D. J. & Heather, L. C., Aug 2018, In : Journal of the American College of Cardiology: Basic to Translational Science. 3, 4, p. 485-498 14 p.

Research output: Contribution to journal › Article

Open Access

File