• 800 Citations
  • 14 h-Index
20062020

Research output per year

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Personal profile

Biography

Michael is a biochemist who studied Biochemistry at Bath University, during this time he spent time at the University of Michigan (USA) and Duke University (USA) for six-month placements. After his studies he worked for a year as a formulations technician at the vaccine company: PowderMed in Oxford. He returned to his studies for a DPhil (PhD) in the Department of Cardiovascular Medicine and the Department of Physiology, Anatomy and Genetics (DPAG) at the University of Oxford. His PhD work was on the application of novel magnetic resonance imaging and spectroscopy tools to better characterize metabolic alterations that occur during heart disease. Developing this further, he undertook a 2 year post-doc sponsored by the British Heart Foundation (BHF) to investigate the translation of his PhD work into human volunteers in the Oxford Centre for Clinical Magnetic Resonance Research. In 2014, Michael was awarded a Novo Nordisk Fellowship, to investigate the effects of fatty acids on the hearts ability to adapt to hypoxia.

Michael's research involves examining the metabolism of the failing and diseased heart. The healthy heart derives 60-80% of its energy from the burning of fat, the rest from carbohydrates and ketones. During heart disease this carefully balanced use of fuel can become breakdown. Understanding why this is the case and how to prevent the deterioration of this metabolic balance may provide clues on how to better treat heart disease.

Education/Academic qualification

DPhil, Doctorate, University of Oxford

1 Oct 200830 Sep 2012

Biochemistry, MSc, University of Bath

1 Sep 200321 Jul 2007

External positions

Novo Nordisk Postdoctoral Fellow, University of Oxford

1 Oct 201431 Mar 2018

BHF Postdoctoral Researcher, University of Oxford

1 Oct 201230 Sep 2014

Keywords

  • QP Physiology
  • Metabolism
  • Heart
  • MRI
  • Hypoxia
  • Diabetes
  • QH301 Biology
  • Metabolism
  • QM Human anatomy
  • Heart

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Research Output

  • 800 Citations
  • 14 h-Index
  • 21 Article
  • 1 Short survey
  • 1 Review article

Non-Invasive In Vivo Assessment of Cardiac Metabolism in the Healthy and Diabetic Human Heart Using Hyperpolarized 13C MRI

Rider, O., Apps, A., Miller, J., Lau, J., Lewis, A., Peterzan, M., Dodd, M., Lau, A., Trumper, C., Gallagher, F., Grist, J., Brindle, K., Neubauer, S. & Tyler, D. J., 13 Mar 2020, In : Circulation Research. 126, 6, p. 725-736 12 p.

Research output: Contribution to journalArticle

Open Access
File
  • 1 Citation (Scopus)
    3 Downloads (Pure)

    Assessing the optimal preparation strategy to minimize the variability of cardiac pyruvate dehydrogenase flux measurements with hyperpolarized MRS

    Timm, K. N., Apps, A., Miller, J. J., Ball, V., Chong, C-R., Dodd, M. & Tyler, D. J., Sep 2018, In : NMR in Biomedicine. 31, 9, 8 p., e3992.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 13 Downloads (Pure)

    Bernard and Joan Marshall Awards at the autumn meeting of the British Society for Cardiovascular Research 2017

    Carr, C. A., Dodd, M. S. & Heather, L. C., 20 Jun 2018, In : Heart. 104, 16

    Research output: Contribution to journalShort survey

  • CPT1a-dependent long-chain fatty acid oxidation is essential for maintaining glucagon secretion from pancreatic islets

    Briant, L. J. B., Dodd, M., Chibalina, M. V., Rorseman, N. J. G., Carmeliet, P., Johnson, P. R. J., Rorsman, P. & Knudsen, J. G., 12 Jun 2018, In : Cell Reports. 23, 11, p. 3300-3311 12 p.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 14 Citations (Scopus)
    52 Downloads (Pure)

    Fatty acids prevent Hypoxia-Inducible Factor 1α signalling in type 2 diabetes

    Dodd, M., Sousa Fialho, M. D. L., Montes Aparico, C. N., Kerr, M., Timm, K. N., Griffin, J. L., Luiken, J. J. F. P., Glatz, J. F. C., Tyler, D. J. & Heather, L. C., Aug 2018, In : Journal of the American College of Cardiology: Basic to Translational Science. 3, 4, p. 485-498 14 p.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 8 Citations (Scopus)
    38 Downloads (Pure)

    Activities

    • 3 Publication peer-review
    • 1 Editorial activity

    Acta Diabetologica (Journal)

    Mike Dodd (Editorial Board Member)
    2018 → …

    Activity: Publication peer-review and editorial workEditorial activity

    Journal of Cardiovascular Magnetic Resonance (Journal)

    Mike Dodd (Peer Reviewer)
    May 2018

    Activity: Publication peer-review and editorial workPublication peer-review

    Acta Diabetologica (Journal)

    Mike Dodd (Peer Reviewer)
    Jun 2018

    Activity: Publication peer-review and editorial workPublication peer-review

    Journal of Cardiovascular Magnetic Resonance (Journal)

    Mike Dodd (Peer Reviewer)
    Jul 2018

    Activity: Publication peer-review and editorial workPublication peer-review