• 697 Citations
  • 13 h-Index
20062018
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Personal profile

Biography

Michael is a biochemist who studied Biochemistry at Bath University, during this time he spent time at the University of Michigan (USA) and Duke University (USA) for six-month placements. After his studies he worked for a year as a formulations technician at the vaccine company: PowderMed in Oxford. He returned to his studies for a DPhil (PhD) in the Department of Cardiovascular Medicine and the Department of Physiology, Anatomy and Genetics (DPAG) at the University of Oxford. His PhD work was on the application of novel magnetic resonance imaging and spectroscopy tools to better characterize metabolic alterations that occur during heart disease. Developing this further, he undertook a 2 year post-doc sponsored by the British Heart Foundation (BHF) to investigate the translation of his PhD work into human volunteers in the Oxford Centre for Clinical Magnetic Resonance Research. In 2014, Michael was awarded a Novo Nordisk Fellowship, to investigate the effects of fatty acids on the hearts ability to adapt to hypoxia.

Michael's research involves examining the metabolism of the failing and diseased heart. The healthy heart derives 60-80% of its energy from the burning of fat, the rest from carbohydrates and ketones. During heart disease this carefully balanced use of fuel can become breakdown. Understanding why this is the case and how to prevent the deterioration of this metabolic balance may provide clues on how to better treat heart disease.

Education/Academic qualification

DPhil, Doctorate, University of Oxford

1 Oct 200830 Sep 2012

Biochemistry, MSc, University of Bath

1 Sep 200321 Jul 2007

External positions

Novo Nordisk Postdoctoral Fellow, University of Oxford

1 Oct 201431 Mar 2018

BHF Postdoctoral Researcher, University of Oxford

1 Oct 201230 Sep 2014

Keywords

  • QP Physiology
  • Metabolism
  • Heart
  • MRI
  • Hypoxia
  • Diabetes
  • QH301 Biology
  • Metabolism
  • QM Human anatomy
  • Heart

Fingerprint Dive into the research topics where Mike Dodd is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

Pyruvic Acid Medicine & Life Sciences
Oxidoreductases Medicine & Life Sciences
Magnetic Resonance Spectroscopy Medicine & Life Sciences
Fatty Acids Medicine & Life Sciences
Citric Acid Cycle Medicine & Life Sciences
Glucose Medicine & Life Sciences
Acetylcarnitine Medicine & Life Sciences
Lysophospholipid Receptors Medicine & Life Sciences

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Research Output 2006 2018

  • 697 Citations
  • 13 h-Index
  • 20 Article
  • 1 Short survey
  • 1 Review article
11 Downloads (Pure)

Assessing the optimal preparation strategy to minimize the variability of cardiac pyruvate dehydrogenase flux measurements with hyperpolarized MRS

Timm, K. N., Apps, A., Miller, J. J., Ball, V., Chong, C-R., Dodd, M. & Tyler, D. J., Sep 2018, In : NMR in Biomedicine. 31, 9, 8 p., e3992.

Research output: Contribution to journalArticle

Open Access
File
Pyruvic Acid
Oxidoreductases
Glucose
Magnetic Resonance Spectroscopy
Bicarbonates

Bernard and Joan Marshall Awards at the autumn meeting of the British Society for Cardiovascular Research 2017

Carr, C. A., Dodd, M. S. & Heather, L. C., 20 Jun 2018, In : Heart. 104, 16

Research output: Contribution to journalShort survey

Research
Atherosclerosis
Myocardium
Research Personnel
Students
5 Citations (Scopus)
42 Downloads (Pure)

CPT1a-dependent long-chain fatty acid oxidation is essential for maintaining glucagon secretion from pancreatic islets

Briant, L. J. B., Dodd, M., Chibalina, M. V., Rorseman, N. J. G., Carmeliet, P., Johnson, P. R. J., Rorsman, P. & Knudsen, J. G., 12 Jun 2018, In : Cell Reports. 23, 11, p. 3300-3311 12 p.

Research output: Contribution to journalArticle

Open Access
File
Glucagon
Islets of Langerhans
Fatty Acids
Oxidation
Pumps
5 Citations (Scopus)
22 Downloads (Pure)

Fatty acids prevent Hypoxia-Inducible Factor 1α signalling in type 2 diabetes

Dodd, M., Sousa Fialho, M. D. L., Montes Aparico, C. N., Kerr, M., Timm, K. N., Griffin, J. L., Luiken, J. J. F. P., Glatz, J. F. C., Tyler, D. J. & Heather, L. C., Aug 2018, In : Journal of the American College of Cardiology: Basic to Translational Science. 3, 4, p. 485-498 14 p.

Research output: Contribution to journalArticle

Open Access
File
Hypoxia-Inducible Factor 1
Type 2 Diabetes Mellitus
Succinic Acid
Fatty Acids
Ischemia
4 Citations (Scopus)

The 'Goldilocks zone' of fatty acid metabolism; to ensure that the relationship with cardiac function is just right

Kerr, M., Dodd, M. S. & Heather, L. C., 24 Jul 2017, In : Clinical Science. 131, 16, p. 2079-2094 16 p.

Research output: Contribution to journalReview article

Fatty Acids
Adenosine Triphosphate
Hypertrophy
Oxygen
Glucose

Activities 2018 2018

  • 3 Publication peer-review
  • 1 Editorial activity

Acta Diabetologica (Journal)

Mike Dodd (Editorial Board Member)
2018 → …

Activity: Publication peer-review and editorial workEditorial activity

Journal of Cardiovascular Magnetic Resonance (Journal)

Mike Dodd (Peer Reviewer)
Jul 2018

Activity: Publication peer-review and editorial workPublication peer-review

Acta Diabetologica (Journal)

Mike Dodd (Peer Reviewer)
Jun 2018

Activity: Publication peer-review and editorial workPublication peer-review

Journal of Cardiovascular Magnetic Resonance (Journal)

Mike Dodd (Peer Reviewer)
May 2018

Activity: Publication peer-review and editorial workPublication peer-review