Research Output per year
Personal profile
Biography
Michael is a biochemist who studied Biochemistry at Bath University, during this time he spent time at the University of Michigan (USA) and Duke University (USA) for six-month placements. After his studies he worked for a year as a formulations technician at the vaccine company: PowderMed in Oxford. He returned to his studies for a DPhil (PhD) in the Department of Cardiovascular Medicine and the Department of Physiology, Anatomy and Genetics (DPAG) at the University of Oxford. His PhD work was on the application of novel magnetic resonance imaging and spectroscopy tools to better characterize metabolic alterations that occur during heart disease. Developing this further, he undertook a 2 year post-doc sponsored by the British Heart Foundation (BHF) to investigate the translation of his PhD work into human volunteers in the Oxford Centre for Clinical Magnetic Resonance Research. In 2014, Michael was awarded a Novo Nordisk Fellowship, to investigate the effects of fatty acids on the hearts ability to adapt to hypoxia.
Michael's research involves examining the metabolism of the failing and diseased heart. The healthy heart derives 60-80% of its energy from the burning of fat, the rest from carbohydrates and ketones. During heart disease this carefully balanced use of fuel can become breakdown. Understanding why this is the case and how to prevent the deterioration of this metabolic balance may provide clues on how to better treat heart disease.Education/Academic qualification
DPhil, Doctorate, University of Oxford
1 Oct 2008 → 30 Sep 2012
Biochemistry, MSc, University of Bath
1 Sep 2003 → 21 Jul 2007
External positions
Novo Nordisk Postdoctoral Fellow, University of Oxford
1 Oct 2014 → 31 Mar 2018BHF Postdoctoral Researcher, University of Oxford
1 Oct 2012 → 30 Sep 2014Keywords
- QP Physiology
- Metabolism
- Heart
- MRI
- Hypoxia
- Diabetes
- QH301 Biology
- Metabolism
- QM Human anatomy
- Heart
Fingerprint Dive into the research topics where Mike Dodd is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
Pyruvic Acid
Medicine & Life Sciences
Oxidoreductases
Medicine & Life Sciences
Magnetic Resonance Spectroscopy
Medicine & Life Sciences
Fatty Acids
Medicine & Life Sciences
Citric Acid Cycle
Medicine & Life Sciences
Glucose
Medicine & Life Sciences
Acetylcarnitine
Medicine & Life Sciences
Lysophospholipid Receptors
Medicine & Life Sciences
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Research Output 2006 2018
Assessing the optimal preparation strategy to minimize the variability of cardiac pyruvate dehydrogenase flux measurements with hyperpolarized MRS
Timm, K. N., Apps, A., Miller, J. J., Ball, V., Chong, C-R., Dodd, M. & Tyler, D. J., Sep 2018, In : NMR in Biomedicine. 31, 9, 8 p., e3992.Research output: Contribution to journal › Article
Open Access
File
Pyruvic Acid
Oxidoreductases
Glucose
Magnetic Resonance Spectroscopy
Bicarbonates
Bernard and Joan Marshall Awards at the autumn meeting of the British Society for Cardiovascular Research 2017
Carr, C. A., Dodd, M. S. & Heather, L. C., 20 Jun 2018, In : Heart. 104, 16Research output: Contribution to journal › Short survey
Research
Atherosclerosis
Myocardium
Research Personnel
Students
CPT1a-dependent long-chain fatty acid oxidation is essential for maintaining glucagon secretion from pancreatic islets
Briant, L. J. B., Dodd, M., Chibalina, M. V., Rorseman, N. J. G., Carmeliet, P., Johnson, P. R. J., Rorsman, P. & Knudsen, J. G., 12 Jun 2018, In : Cell Reports. 23, 11, p. 3300-3311 12 p.Research output: Contribution to journal › Article
Open Access
File
Glucagon
Islets of Langerhans
Fatty Acids
Oxidation
Pumps
Fatty acids prevent Hypoxia-Inducible Factor 1α signalling in type 2 diabetes
Dodd, M., Sousa Fialho, M. D. L., Montes Aparico, C. N., Kerr, M., Timm, K. N., Griffin, J. L., Luiken, J. J. F. P., Glatz, J. F. C., Tyler, D. J. & Heather, L. C., Aug 2018, In : Journal of the American College of Cardiology: Basic to Translational Science. 3, 4, p. 485-498 14 p.Research output: Contribution to journal › Article
Open Access
File
Hypoxia-Inducible Factor 1
Type 2 Diabetes Mellitus
Succinic Acid
Fatty Acids
Ischemia
3
Citations
(Scopus)
The 'Goldilocks zone' of fatty acid metabolism; to ensure that the relationship with cardiac function is just right
Kerr, M., Dodd, M. S. & Heather, L. C., 24 Jul 2017, In : Clinical Science. 131, 16, p. 2079-2094 16 p.Research output: Contribution to journal › Review article
Fatty Acids
Adenosine Triphosphate
Hypertrophy
Oxygen
Glucose
Activities 2018 2018
Journal of Cardiovascular Magnetic Resonance (Journal)
Mike Dodd (Peer Reviewer)May 2018
Activity: Publication peer-review and editorial work › Publication peer-review
Journal of Cardiovascular Magnetic Resonance (Journal)
Mike Dodd (Peer Reviewer)Jul 2018
Activity: Publication peer-review and editorial work › Publication peer-review
Acta Diabetologica (Journal)
Mike Dodd (Peer Reviewer)Jun 2018
Activity: Publication peer-review and editorial work › Publication peer-review
Acta Diabetologica (Journal)
Mike Dodd (Editorial Board Member)2018 → …
Activity: Publication peer-review and editorial work › Editorial activity