Research output per year
Research output per year
Personal profile
Biography
Dr Jennifer Greaves is a UKRI Future Leaders Fellow in the Centre for Sports, Exercise and Life Sciences.
Dr Greaves completed a BSc in Biochemistry with honours and MRes in Molecular Cell Biology at the University of Edinburgh. Her PhD at the University of Glasgow identified how protein-membrane interactions of soluble S-acylated proteins are regulated by zDHHC S-acylating enzymes.
Her postdoctoral studies at the Universities of Edinburgh and Strathclyde with Professor Luke Chamberlain included collaborations on a variety of interdisciplinary projects as well as time at the University of Michigan in Ann Arbor, USA, as a visiting scientist on a fellowship supported by Scottish Universities Life Sciences Alliance (SULSA) and Tenovus Scotland. In 2020, she was awarded an Academy of Medical Sciences Springboard Award to investigate the function and substrate interaction network of ABHD16A, a novel regulator of protein S-acylation.
Research Interests
Dr Greaves’ research uses a combination of cellular, molecular and chemical-biology techniques to investigate how the metabolic serine hydrolase enzymes regulate the posttranslational protein-lipid modification S-acylation (palmitoylation).
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Biochemistry and Molecular Biology, Doctorate, Palmitoylation and membrane interactions of Cysteine String Protein, University of Glasgow
1 Nov 2003 → 31 Oct 2007
Award Date: 1 Dec 2008
Molecular Cell Biology , MSc, University of Edinburgh
1 Mar 2001 → 28 Feb 2003
Award Date: 1 Jul 2003
Biochemistry, Degree, University of Edinburgh
1 Oct 1996 → 30 Jun 2000
Award Date: 1 Jul 2000
External positions
Programme Coordinator, Lipidation in Cell Biology and Disease conference, Biochemical Society
14 Sept 2021 → 16 Sept 2021
Scientific Outreach Grant Reviewer, Biochemical Society
1 Sept 2019 → …
Editorial Board Member, PLoS One
1 Sept 2018 → …
Keywords
- Q Science (General)
- Palmitoylation
- S-acylation
- Acyl Protein Thioesterase
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Collaborations and top research areas from the last five years
External collaboration on country/territory level for the past five years. Dive into details by clicking on the dots or
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Fam49/CYRI interacts with Rac1 and locally suppresses protrusions
Fort, L., Batista, J. M., Thomason, P. A., Spence, H. J., Whitelaw, J. A., Tweedy, L., Greaves, J., Martin, K. J., Anderson, K. I., Brown, P., Lilla, S., Neilson, M. P., Tafelmeyer, P., Zanivan, S., Ismail, S., Bryant, D. M., Tomkinson, N. C. O., Chamberlain, L. H., Mastick, G. S., Insall, R. H., & 1 others, Oct 2018, In: Nature Cell Biology. 20, p. 1159-1171 13 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile51 Citations (Scopus)49 Downloads (Pure) -
Molecular basis of fatty acid selectivity in the zDHHC family of S-acyltransferases revealed by click chemistry
Greaves, J., Munro, K. R., Davidson, S. C., Riviere, M., Wojno, J., Smith, T. K., Tomkinson, N. C. O. & Chamberlain, L. H., 21 Feb 2017, In: Proceedings of the National Academy of Sciences of the United States of America. 114, 8, p. E1365-E1374 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile110 Citations (Scopus)82 Downloads (Pure) -
S-acylation regulates the trafficking and stability of the unconventional Q-SNARE STX19
Ampah, K. K., Greaves, J., Shun-Shion, A. S. M., Asnawi, A. W. B. A., Lidster, J. A., Chamberlain, L. H., Collins, M. O. & Peden, A. A., 22 Oct 2018, In: Journal of Cell Science. 131, 20, 48 p., jcs212498.Research output: Contribution to journal › Article › peer-review
Open AccessFile7 Citations (Scopus)66 Downloads (Pure) -
LIF-dependent survival of embryonic stem cells is regulated by a novel palmitoylated Gab1 signalling protein
Sutherland, L., Ruhe, M., Gattegno-Ho, D., Mann, K., Greaves, J., Koscielniak, M., Meek, S., Lu, Z., Waterfall, M., Taylor, R., Tsakiridis, A., Brown, H., Maciver, S. K., Joshi, A., Clinton, M., Chamberlain, L. H., Smith, A. & Burdon, T., 20 Sept 2018, In: Journal of Cell Science. 131, 18, jcs222257.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Citations (Scopus)57 Downloads (Pure) -
Palmitoylation-dependent protein sorting
Greaves, J. & Chamberlain, L. H., 29 Jan 2007, In: Nature Cell Biology. 176, 3, p. 249-254 6 p.Research output: Contribution to journal › Review article › peer-review
206 Citations (Scopus)