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Research Output 2009 2019

2019
3 Citations (Scopus)

Clinical proof of concept for a safe and effective NF-κB-targeting strategy in multiple myeloma

Tornatore, L., Capece, D., D'Andrea, D., Begalli, F., Verzella, D., Bennett, J., Acton, G., Campbell, E. A., Kelly, J., Tarbit, M., Adams, N., Bannoo, S., Leonardi, A., Sandomenico, A., Raimondo, D., Ruvo, M., Chambery, A., Oblak, M., Al-Obaidi, M. J., Kaczmarski, R. S. & 1 othersGabriel, I., May 2019, In : British Journal of Haematology. 185, 3, p. 588-592 5 p.

Research output: Contribution to journalLetter

Multiple Myeloma

Cocaine addicted to cytoskeletal change and a fibrosis high

Verma, A., Bennett, J., Örme, A. M., Polycarpou, E. & Rooney, B., 1 Feb 2019, In : Cytoskeleton. 76, 2, p. 177-185 9 p.

Research output: Contribution to journalReview article

Cocaine
Fibrosis
Microfilament Proteins
Hepatic Stellate Cells
Cocaine-Related Disorders
1 Citation (Scopus)
3 Downloads (Pure)

Preclinical toxicology and safety pharmacology of the first-in-class GADD45β/MKK7 inhibitor and clinical candidate, DTP3

Tornatore, L., Capece, D., D'Andrea, D., Begalli, F., Verzella, D., Bennett, J., Acton, G., Campbell, E. A., Kelly, J., Tarbit, M., Adams, N., Bannoo, S., Leonardi, A., Sandomenico, A., Raimondo, D., Ruvo, M., Chambery, A., Oblak, M., Al-Obaidi, M. J., Kaczmarski, R. S. & 8 othersGabriel, I., Oakervee, H. E., Kaiser, M. F., Wechalekar, A., Benjamin, R., Apperley, J. F., Auner, H. W. & Franzoso, G., 2019, In : Toxicology Reports. 6, p. 369-379 11 p.

Research output: Contribution to journalArticle

Open Access
File
Multiple Myeloma
Toxicology
Toxicity
Oncology
Pharmacology
2018
7 Citations (Scopus)

GADD45β Loss Ablates Innate Immunosuppression in Cancer

Verzella, D., Bennett, J., Fischietti, M., Thotakura, A. K., Recordati, C., Pasqualini, F., Capece, D., Vecchiotti, D., D'Andrea, D., Di Francesco, B., De Maglie, M., Begalli, F., Tornatore, L., Papa, S., Lawrence, T., Forbes, S. J., Sica, A., Alesse, E., Zazzeroni, F. & Franzoso, G., Mar 2018, In : Cancer Research. 78, 5, p. 1275-1292 18 p.

Research output: Contribution to journalArticle

Immunosuppression
Neoplasms
Tumor Microenvironment
T-Lymphocytes
Macrophages
7 Citations (Scopus)

NF-κB in the crosshairs: Rethinking an old riddle

Bennett, J., Capece, D., Begalli, F., Verzella, D., D'Andrea, D., Tornatore, L. & Franzoso, G., Feb 2018, In : International Journal of Biochemistry and Cell Biology. 95, p. 108-112 5 p.

Research output: Contribution to journalArticle

Open Access
File
Tissue homeostasis
Pathology
Drug Discovery
Medicine
Toxicity
9 Citations (Scopus)
1 Downloads (Pure)

Turning an old GADDget into a troublemaker

Capece, D., D'Andrea, D., Verzella, D., Tornatore, L., Begalli, F., Bennett, J., Zazzeroni, F. & Franzoso, G., 6 Mar 2018, In : Cell Death & Differentiation. 25, p. 642–644 3 p.

Research output: Contribution to journalComment/debate

Open Access
File
Cells
Infection
Parasite
Immunity
2017
19 Citations (Scopus)

Unlocking the NF-κB Conundrum: Embracing Complexity to Achieve Specificity

Bennett, J., 22 Aug 2017, In : Biomedicines. 5, 3, 35 p., 50.

Research output: Contribution to journalArticle

Open Access
Drug Industry
Type 1 Diabetes Mellitus
Vascular Diseases
Chronic Disease
Transcription Factors
2016
3 Downloads (Pure)

Tacrolimus Modulates TGF-β Signaling to Induce Epithelial-Mesenchymal Transition in Human Renal Proximal Tubule Epithelial Cells

Bennett, J., Cassidy, H., Slattery, C., Ryan, M. P. & McMorrow, T., 26 Apr 2016, In : Journal of Clinical Medicine. 5, 5, 23 p., 50.

Research output: Contribution to journalArticle

Open Access
File
Proximal Kidney Tubule
Epithelial-Mesenchymal Transition
Tacrolimus
Epithelial Cells
Fibrosis
2014
78 Citations (Scopus)
3 Downloads (Pure)

Integrin CD11b positively regulates TLR4-induced signalling pathways in dendritic cells but not in macrophages

Ling, G. S., Bennett, J., Woollard, K. J., Szajna, M., Fossati-Jimack, L., Taylor, P. R., Scott, D., Franzoso, G., Cook, H. T. & Cook, H. T., 15 Jan 2014, In : Nature Communications. 5, 12 p., 3039.

Research output: Contribution to journalArticle

Open Access
File
Toll-Like Receptor 4
macrophages
Macrophages
Integrins
Dendritic Cells
2013
3 Citations (Scopus)

The Regulation of the JNK Cascade and Programmed Cell Death by NF-κB: Mechanisms and Functions.

Bennett, J., Moretti, M., Thotakura, AK., Tornatore, L. & Franzoso, G., 2013, Trends in Stem Cell Proliferation and Cancer Research.. Resende, R. R. & Ulrich, H. (eds.). Springer Science + Business Media, p. 297-338 42 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

JNK Mitogen-Activated Protein Kinases
Cell Death
Reactive Oxygen Species
Neoplasms
Combat Disorders
2012
31 Citations (Scopus)

Cancer: NF-κB regulates energy metabolism

Moretti, M., Bennett, J., Tornatore, L., Thotakura, A. K. & Franzoso, G., Dec 2012, In : International Journal of Biochemistry and Cell Biology. 44, 12, p. 2238-2243 6 p.

Research output: Contribution to journalArticle

Pathology
Energy Metabolism
Gene encoding
Oncology
Physiology
213 Citations (Scopus)

The nuclear factor kappa B signaling pathway: integrating metabolism with inflammation

Tornatore, L., Thotakura, A. K., Bennett, J., Moretti, M. & Franzoso, G., 1 Nov 2012, In : Trends in Cell Biology. 22, 11, p. 557-566 10 p.

Research output: Contribution to journalArticle

NF-kappa B
Inflammation
Metabolic Diseases
Carcinogenesis
Glycolysis
2009
25 Citations (Scopus)

Inter-laboratory comparison of human renal proximal tubule (HK-2) transcriptome alterations due to Cyclosporine A exposure and medium exhaustion.

Jennings, P., Aydin, S., Bennett, J., McBride, R., Weiland, C., Tuite, N., Gruber, L. N., Perco, P., Gaora, P. Ó., Ellinger-Ziegelbauer, H., Ahr, H-J., Van Kooten, C., Daha, M. R., Prieto, P., Ryan, M. P., Pfaller, W. & McMorrow, T., Apr 2009, In : Toxicology in Vitro. 23, 3, p. 486-499 14 p.

Research output: Contribution to journalArticle

Proximal Kidney Tubule
Transcriptome
Cyclosporine
Genes
DNA