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Personal profile

Research Interests

Cancer immunotherapy has represented a paradigm shift in cancer therapy. However, at present immunotherapies help only a minority of patients and in certain types of cancer they are unsuccessful due to the overriding immunosuppression mechanisms in the tumour microenvironment (TME). The mechanisms underlying the immunoinhibitory activities of the TME are presently poorly understood. My research aims to apply various molecular biological techniques to discover novel non-enzymatic modulators of key pro-inflammatory signalling pathways. This could potentially identify and target key protein-protein interactions in order to release the “natural brakes” of inflammatory signalling pathways in innate immune cells. This research will advance our understanding of the regulatory mechanisms of innate immune cell signalling in the host’s response to pathogens and cancer leading to the development of a new class of innate immunotherapies, which will be able to convert immunological “cold” tumours (e.g. prostate, glioblastoma, ovarian and pancreatic cancer) into ones that are responsive to immunotherapy.

Education/Academic qualification

Post-doctoral Research Fellow, Imperial College London

1 Jan 201131 Dec 2018

PhD, Doctorate, University College Dublin

31 Oct 20041 Nov 2009

External positions

Honorary Research Fellow, Imperial College London

1 Jan 2019 → …

Keywords

  • RM Therapeutics. Pharmacology
  • Cancer Immunotherapy
  • Innate Immune Signalling
  • Tumor Microenvironment
  • Metabolism

Fingerprint Dive into the research topics where Jason Bennett is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 4 Similar Profiles
Neoplasms Medicine & Life Sciences
Proximal Kidney Tubule Medicine & Life Sciences
Multiple Myeloma Medicine & Life Sciences
Transcription Factors Medicine & Life Sciences
Drug Industry Medicine & Life Sciences
Immunosuppression Medicine & Life Sciences
Toll-Like Receptor 4 Medicine & Life Sciences
Carcinogenesis Medicine & Life Sciences

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Research Output 2009 2019

3 Citations (Scopus)

Clinical proof of concept for a safe and effective NF-κB-targeting strategy in multiple myeloma

Tornatore, L., Capece, D., D'Andrea, D., Begalli, F., Verzella, D., Bennett, J., Acton, G., Campbell, E. A., Kelly, J., Tarbit, M., Adams, N., Bannoo, S., Leonardi, A., Sandomenico, A., Raimondo, D., Ruvo, M., Chambery, A., Oblak, M., Al-Obaidi, M. J., Kaczmarski, R. S. & 1 othersGabriel, I., May 2019, In : British Journal of Haematology. 185, 3, p. 588-592 5 p.

Research output: Contribution to journalLetter

Multiple Myeloma

Cocaine addicted to cytoskeletal change and a fibrosis high

Verma, A., Bennett, J., Örme, A. M., Polycarpou, E. & Rooney, B., 1 Feb 2019, In : Cytoskeleton. 76, 2, p. 177-185 9 p.

Research output: Contribution to journalReview article

Cocaine
Fibrosis
Microfilament Proteins
Hepatic Stellate Cells
Cocaine-Related Disorders
1 Citation (Scopus)
2 Downloads (Pure)

Preclinical toxicology and safety pharmacology of the first-in-class GADD45β/MKK7 inhibitor and clinical candidate, DTP3

Tornatore, L., Capece, D., D'Andrea, D., Begalli, F., Verzella, D., Bennett, J., Acton, G., Campbell, E. A., Kelly, J., Tarbit, M., Adams, N., Bannoo, S., Leonardi, A., Sandomenico, A., Raimondo, D., Ruvo, M., Chambery, A., Oblak, M., Al-Obaidi, M. J., Kaczmarski, R. S. & 8 othersGabriel, I., Oakervee, H. E., Kaiser, M. F., Wechalekar, A., Benjamin, R., Apperley, J. F., Auner, H. W. & Franzoso, G., 2019, In : Toxicology Reports. 6, p. 369-379 11 p.

Research output: Contribution to journalArticle

Open Access
File
Multiple Myeloma
Toxicology
Toxicity
Oncology
Pharmacology
6 Citations (Scopus)

GADD45β Loss Ablates Innate Immunosuppression in Cancer

Verzella, D., Bennett, J., Fischietti, M., Thotakura, A. K., Recordati, C., Pasqualini, F., Capece, D., Vecchiotti, D., D'Andrea, D., Di Francesco, B., De Maglie, M., Begalli, F., Tornatore, L., Papa, S., Lawrence, T., Forbes, S. J., Sica, A., Alesse, E., Zazzeroni, F. & Franzoso, G., Mar 2018, In : Cancer Research. 78, 5, p. 1275-1292 18 p.

Research output: Contribution to journalArticle

Immunosuppression
Neoplasms
Tumor Microenvironment
T-Lymphocytes
Macrophages
7 Citations (Scopus)

NF-κB in the crosshairs: Rethinking an old riddle

Bennett, J., Capece, D., Begalli, F., Verzella, D., D'Andrea, D., Tornatore, L. & Franzoso, G., Feb 2018, In : International Journal of Biochemistry and Cell Biology. 95, p. 108-112 5 p.

Research output: Contribution to journalArticle

Open Access
File
Tissue homeostasis
Pathology
Drug Discovery
Medicine
Toxicity