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Personal profile

Biography

I have over 20 years’ experience of studying the regulation of gene expression in several biological systems. My PhD led to the first description of a system for large-scale production of proteins in vitro. This included a coupled transcription-translation system (four patents filed) and a replication-translation process (two patents filed) that have been licensed to Ambion and Promega and are used worldwide. It also led to me receiving the prestigious European Academia Prize in Medicine and Biology for young scientists in 1995 and in 2006 I was awarded a personal fellowship by The Austrian Research Council to conduct my research into RNA degradation at BOKU University, Vienna. Since then, I have worked at CNRS (France), Penn State University (USA) and the University of Liverpool. My research into gene expression systems during my tenure at the University of Liverpool resulted in the characterisation of a specific mechanism by which the nitrogen metabolite signalling pathways are controlled in A. nidulans as well as discovery a new regulatory pathway of gene expression. This work is of a global nature, will make a major contribution to refining models of gene expression and regulation.

Vision Statement

The underlying mechanisms that dictate eukaryotic life, disease, and death are bound by the central dogma of molecular biology. Thus, regulation of gene expression is the result of the combined control of mRNA production and function. Improper regulation of gene expression can lead to many defects and disorders. Consequently, understanding the fundamental mechanisms of gene expression has become a dynamic subfield of genetic diseases and medicine. The aim of my research is to investigate the coordinated regulation of crucial cellular processes such as translation, mRNA modification, quality control, cellular compartmentalisation of RNA and decay. Isolation of research in these areas has left big gaps in our understanding into how all these events are linked to and regulate each other.

Fingerprint Dive into the research topics where Igor Morozov is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 1 Similar Profiles
Aspergillus nidulans Medicine & Life Sciences
Dysbiosis Medicine & Life Sciences
Cell-Free System Medicine & Life Sciences
Messenger RNA Medicine & Life Sciences
Gene Expression Medicine & Life Sciences
RNA Stability Medicine & Life Sciences
Cytidine Diphosphate Medicine & Life Sciences
Cytidine Triphosphate Medicine & Life Sciences

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Research Output 1989 2019

  • 34 Citations
  • 2 h-Index
  • 6 Article
  • 4 Patent

mRNA levels are buffered upon knockdown of RNA decay and translation factors via adjustment of transcription rates in human HepG2 cells

Singh, P., James, R., Mee, C. & Morozov, I., 2 Sep 2019, In : RNA Biology. 16, 9, p. 1147-1155 9 p.

Research output: Contribution to journalArticle

RNA Stability
Hep G2 Cells
Messenger RNA
Half-Life
Mammals

Preventive antibiotic treatment of calves: emergence of dysbiosis causing propagation of obese state-associated and mobile multidrug resistance-carrying bacteria

Dobrzanska, D. A., Lamaudière, M. T. F., Rollason, J., Acton, L., Duncan, M., Compton, S., Simms, J., Weedall, G. D. & Morozov, I. Y., 30 Oct 2019, In : Microbial Biotechnology. (In-Press), p. (In-Press) 14 p.

Research output: Contribution to journalArticle

Open Access
File
Dysbiosis
Multiple Drug Resistance
Anti-Bacterial Agents
Bacteria
Microbiota

Microbiota of the gut: Antibiotic-Induced Dysbiosis and the Adverse Effects on Human Health

Lamaudiere, M. & Morozov, I., 16 Oct 2018, Sci J Gastroenterol & Hepatol, 1, 1, p. 000504 3 p.

Research output: Contribution to specialist publicationArticle

Open Access
File
Dysbiosis
Anti-Bacterial Agents
Health
Proteobacteria
Microbial Drug Resistance

Aspergillus nidulans Upf1: putative role of conserved active sites in ribosome recycling and 3′ end mRNA tagging

Morozov, I. & Langley, R., 16 Jun 2015, In : Bioscience Horizons . 8, 1, p. 1-11 12 p., hzv004 doi:10.1093/biohorizons/hzv004.

Research output: Contribution to journalArticle

Aspergillus nidulans
Aspergillus
ribosomes
Ribosomes
active sites
5 Citations (Scopus)
7 Downloads (Pure)

RrmA regulates the stability of specific transcripts in response to both nitrogen source and oxidative stress

Krol, K., Morozov, I., Jones, M. G., Wyszomirski, T., Weglenski, P., Dzikowska, A. & Caddick, M. X., 2013, In : Molecular Microbiology. 89, 5, p. 975-988

Research output: Contribution to journalArticle

Open Access
File
Glutamine
Oxidative Stress
Nitrogen
Gene Expression
Aspergillus nidulans

Activities 2015 2019

Antimicrobial Resistance in the Real World Integration Programme

Igor Morozov (Chair), Lauren Acton (Organising Committee), Jess Rollason (Organising Committee)
Feb 2019

Activity: Participating in or organising an eventParticipation in conference

Antibiotic Treatment for Livestock: A preventative measure against bacterial infections or aiding in the spread of resistance?

Igor Morozov (Speaker), Matthew Lamaudiere (Speaker)
18 Jun 2018

Activity: Participating in or organising an eventPublic Engagement Event

Circulation (Journal)

Igor Morozov (Peer Reviewer)
Mar 2018

Activity: Publication peer-review and editorial workPublication peer-review

External PhD examiner

Igor Morozov (Examiner)
May 2017

Activity: Examination

External PhD examiner

Igor Morozov (Examiner)
Nov 2016

Activity: Examination

Prizes

Group Processes

Coventry Excellence Awards

Igor Morozov (Recipient), Sharon Williams (Recipient), Jess Rollason (Recipient), Lauren Acton (Recipient) & Martin Cox (Recipient), 15 Jun 2015

Prize: Prize (including medals and awards)

Coventry Excellence Awards 2015

Igor Morozov (Recipient), 2015

Prize: Prize (including medals and awards)

teaching research

Fellow of the Higher Education Academy

Igor Morozov (Recipient), 2015

Prize: Election to learned society

academy
education