Research output per year
Research output per year
Personal profile
Biography
Dr. Hoor Ayub is a research scientist within the Centre for Sports, Health and Life Sciences. She joined Coventry University in July 2019 as a postdoctoral researcher, working on membrane protein pharmacology and molecular biology. Hoor's current research is on understanding the structure, function and underlying molecular mechanism of G-protein coupled receptors (GPCRs) in the presence of receptor activity modifying proteins (RAMPs). Hoor's work is funded by BBSRC- industrial partnership award with Prof Mark Wheatley and in collaboration with Aston University, University of Birmingham and UCB biopharmaceutical company.
Hoor completed her PhD in membrane protein biology and biotechnology from Aston University and in collaboration with Janssen, UK. Her PhD work gave rise to data on (i) stabilisation and purification of difficult to study membrane proteins in SMA co-polymers; (ii) novel biochemical, functional and structural data on tetraspanin family of membrane proteins; (iii) large-scale membrane protein production for X-ray crystallisation and cryo-electron microscopy studies.
Education/Academic qualification
Biochemistry & Biotechnology, Doctorate, Aston University
8 Jul 2016 → 30 Jun 2019
Award Date: 15 Jan 2020
Molecular Biotechnology, MSc, University of Birmingham
1 Sep 2014 → 30 Aug 2015
Award Date: 15 Dec 2015
External positions
Health and Life Sciences Visiting Researcher, Aston University
15 Jul 2019 → 30 Jun 2023
Biosciences Visiting Researcher, University of Birmingham
15 Jul 2019 → 30 Jun 2023
Keywords
- Q Science (General)
- G-Protein-Coupled Receptors (GPCRs) Pharmacology
- Biochemistry & Biotechnology
- GPCR:RAMP interactions
- Calcitonin Gene-Related Peptide Receptor
- Receptor Activity Modifying Proteins
- Family B GPCRs
- Styrene Maleic Acid Lipid Particles
- Nanobodies
- Immunohistochemistry
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Detergent-Free Membrane Protein Purification Using SMA Polymer
Broadbent, L., Depping, P., Lodé, A., Vaitsopoulou, A., Hardy, D., Ayub, H., Mitchell-White, J., Kerr, I. D., Goddard, A. D., Bill, R. M. & Rothnie, A. J., 1 Jul 2022, Heterologous Expression of Membrane Proteins. Methods in Molecular Biology. Mus-Veteau, I. (ed.). Humana Press, Vol. 2507. p. 389-404 16 p. (Methods in molecular biology (Clifton, N.J.)).Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
1 Citation (Scopus) -
Membrane Protein Production in the Yeast P. pastoris
Ayub, H., Clare, M., Broadbent, L., Simms, J., Goddard, A. D., Rothnie, A. J. & Bill, R. M., 1 Jul 2022, Heterologous Expression of Membrane Proteins. Methods in Molecular Biology. Mus-Veteau, I. (ed.). Humana Press, Vol. 2507. p. 187-199 13 p. (Methods in molecular biology (Clifton, N.J.)).Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
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Calcium: Calcitonin gene-related peptide and adrenomedullin receptors
Ayub, H., Grime, R., Poyner, D. & Wheatley, M., 29 Jul 2021, Encyclopedia of Biological Chemistry: Third Edition. Elsevier, Vol. 6. p. 562-570 9 p.Research output: Chapter in Book/Report/Conference proceeding › Entry for encyclopedia/dictionary › peer-review
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The immune receptor FcR chain mediates CD36-oxidized low-density lipoprotein-induced platelet activation and thrombosis
Ayub, H., Uddin, R., Tomlinson, M. & Naseem, K., 2021, (Submitted) In: Proceedings of the National Academy of Sciences. p. (In-Press)Research output: Contribution to journal › Article
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CD81 extracted in SMALP nanodiscs comprises two distinct protein populations within a lipid environment enriched with negatively charged headgroups
Ayub, H., Clare, M., Milic, I., Chmel, N., Boning, H., Devitt, A., Krey, T., Bill, R. M. & Rothnie, A. J., 1 Nov 2020, In: Biochimica et Biophysica Acta - Biomembranes. 1862, 11, 15 p., 183419.Research output: Contribution to journal › Article › peer-review
Open AccessFile9 Citations (Scopus)4 Downloads (Pure)