Hoor Ayub

Hoor Ayub

Dr

    Accepting PhD Students

    PhD projects

    Understanding structure and function of G-protein-coupled receptors

    20202024

    Research activity per year

    Personal profile

    Research Interests

    My research employs multi-disciplinary approaches combining molecular pharmacology, biophysical analysis and peptide chemistry to study ligand binding and signalling activity of G-protein-coupled receptors (GPCRs). My research focus is on family A and B receptors and receptor activity-modifying proteins (RAMPs) that are known to play crucial roles in human health and disease. 

    Techniques employed in my research group are mammalian cell culture, recombinant GPCR expression, solubilisation and purification using detergents, SMA and SMA-like copolymers, cell signalling assays and fluorescence/bioluminescence resonance energy transfer (FRET/BRET) based assays to study macromolecular interactions. 

    Expertise related to UN Sustainable Development Goals

    In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

    • SDG 3 - Good Health and Well-being

    Education/Academic qualification

    Biochemistry & Biotechnology, Doctorate, Membrane phospholipids as regulators of tetraspanin oligomerisation, Aston University

    8 Jul 201630 Jun 2019

    Award Date: 15 Jan 2020

    Molecular Biotechnology, MSc, University of Birmingham

    1 Sept 201430 Aug 2015

    Award Date: 15 Dec 2015

    External positions

    Health and Life Sciences Visiting Researcher, Aston University

    15 Jul 201930 Jun 2023

    Biosciences Visiting Researcher, University of Birmingham

    15 Jul 201930 Jun 2023

    Keywords

    • Q Science (General)
    • G-Protein-Coupled Receptors (GPCRs) Pharmacology
    • Biochemistry & Biotechnology
    • GPCR:RAMP interactions
    • Calcitonin Gene-Related Peptide Receptor
    • Receptor Activity Modifying Proteins
    • Family B GPCRs
    • Styrene Maleic Acid Lipid Particles
    • Nanobodies
    • Immunohistochemistry

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