Personal profile

Biography

I obtained my BSc (Hons) Biochemistry in 2002 and an MSc Biochemistry in 2005 at the University of Copenhagen, Denmark. After my training I was employed as a research assistant at Panum Institute with Prof. Sakari Kauppinen and as a result I obtained a great deal of experience in a number of techniques that are of great value, including print of LNA microarrays, hybridization of microRNA samples to LNA microarrays, scanning, analysis of the results, and real time PCR validation of microRNAs.

I successfully undertook and defended my PhD at the Department of Clinical Experimental Research at the Glostrup Research Institute (Glostrup University Hospital, Denmark) in March 2011. During my PhD I undertook studies using techniques such as wire myography, real time PCR, and immunohistochemistry. After my PhD I worked on an interim project in collaboration with Prof. Flemming Pociot in the same department at Glostrup Hopsital, investigating biomarkers of diabetes type I in children, employing real time PCR techniques to observe microRNA differential expression.

I am now employed at FRC ABES (Coventry University) as a Postdoctoral fellow in the research team of Profs Alfonso Jimenez and Helen Maddock, where I am assessing the effect of chemotherapy treatment-induced cardiotoxicity in vulnerable patient groups, such as children. Early assessment of cardiac injury and implementation of adjunct therapy options are explored in our diverse and dynamic team.

 

Research Interests

MicroRNA biomarkers ; Early detection of drug-induced cardiotoxicity ; Insulin resistance in women with Polycystic Ovarian Syndrome; Polycystic Ovarian Syndrome associated diabetes and cardiovascular diseases; Drug safety, validation and optimisation using in vitro disease models mimicking in vivo pathways

Vision Statement

 

Early detection of drug-induced cardiotoxicity is an important area of research, as reliable assessment method is still lacking specificity and sensitivity. A translational pre-clinical to clinical project including the latest molecular biology and genomic assays, including microRNA expression profiling, will aim to determine the feasibility of using a variety of biochemical and genomic microRNA biomarkers to help determine subclinical cardiac dysfunction in patients treated with chemotherapy. The intracellular pathways linked to cardiac injury develoment are unraveled and adjunct therapy options are explored. The research projects are instinctive progression of my current research expertise, combining genomic and molecular biology techniques to determine the complex links between drug safety interactions and pathophysiological disease conditions.

Education / Academic qualification

Degree, University of Copenhagen

1 Jan 200811 Mar 2011

MSc, University of Copenhagen

1 Aug 199930 Sep 2005

MBA, Niels Brock Copenhagen Business College

1 Jul 19991 Aug 1998

Keywords

  • RM Therapeutics. Pharmacology
  • cardiovascular
  • microRNA
  • adjunct therapy
  • RC0254 Neoplasms. Tumors. Oncology (including Cancer)
  • RG Gynecology and obstetrics
  • polycystic ovarian syndrome
  • insulin resistance
  • RZ Other systems of medicine

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

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Research Output 2010 2017

Attenuation of Sunitinib-induced cardiotoxicity through the A3 adenosine receptor activation

Sandhu, H., Cooper, S., Hussain, A., Mee, C. & Maddock, H. 12 Aug 2017 In : European Journal of Pharmacology. (in press), p. (in press) 11 p.

Research output: Contribution to journalArticle

Adenosine A3 Receptors
HL-60 Cells
Cardiotoxicity
Neoplasms
MicroRNAs
15 Citations
MicroRNAs
Biological Markers
Wounds and Injuries
Neoplasms
Cardiotoxicity
3 Citations

Alteration in contractile G-protein coupled receptor expression by moist snus and nicotine in rat cerebral arteries

Sandhu, H., Xu, C. B. & Edvinsson, L. 2011 In : Toxicology and Applied Pharmacology. 252, 2, p. 138-149

Research output: Contribution to journalArticle

Contractile Proteins
Cerebral Arteries
G-Protein-Coupled Receptors
Nicotine
17 Citations

Comparison of MEK/ERK pathway inhibitors on the upregulation of vascular G-protein coupled receptors in rat cerebral arteries

Sandhu, H., Ansar, S. & Edvinsson, L. Oct 2010 In : European Journal of Pharmacology. 644, 1-3, p. 128-137

Research output: Contribution to journalArticle

Cerebral Arteries
MAP Kinase Signaling System
G-Protein-Coupled Receptors
Blood Vessels
Up-Regulation
20 Citations
Endothelin B Receptors
Cerebral Arteries
Up-Regulation
Smoking
Lipids

Activities 2015 2015

  • 1 Editorial activity
  • 1 Visiting an external academic institution

Clinics in Mother & Child Health (Journal)

Sandhu, H. (Editorial Board Member)
1 Nov 2015

Activity: Editorial activity

Bablake School

Sandhu, H. (Supervisor)
1 Oct 201530 Nov 2015

Activity: Visiting an external academic institution

Prizes

Annum Scholarship

Hardip Sandhu (Recipient), 1 Jan 2008

Prize: Prize (including medals and awards)

International Fellowship award

Hardip Sandhu (Recipient), 1 Sep 2011

Prize: Prize (including medals and awards)

ISCBFM Young Investigators award

Hardip Sandhu (Recipient), 1 Jun 2008

Prize: Prize (including medals and awards)

Jr. Investigator Travel Award

Hardip Sandhu (Recipient), 1 Sep 2013

Prize: Prize (including medals and awards)

PhD stipend and scholarship

Hardip Sandhu (Recipient), 1 Apr 2007

Prize: Prize (including medals and awards)