Photo of Hardip Sandhu
  • Source: Scopus
  • Calculated based on no. of publications stored in Pure and citations from Scopus
20102019

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Personal profile

Biography

I obtained my BSc (Hons) Biochemistry in 2002 and an MSc Biochemistry in 2005 at the University of Copenhagen, Denmark. After my training I was employed as a research assistant at Panum Institute with Prof. Sakari Kauppinen and as a result I obtained a great deal of experience in a number of techniques that are of great value, including print of LNA microarrays, hybridization of microRNA samples to LNA microarrays, scanning, analysis of the results, and real time PCR validation of microRNAs.

I successfully undertook and defended my PhD at the Department of Clinical Experimental Research at the Glostrup Research Institute (Glostrup University Hospital, Denmark) in March 2011. During my PhD I undertook studies using techniques such as wire myography, real time PCR, and immunohistochemistry. After my PhD I worked on an interim project in collaboration with Prof. Flemming Pociot in the same department at Glostrup Hopsital, investigating biomarkers of diabetes type I in children, employing real time PCR techniques to observe microRNA differential expression.

I am now employed at FRC ABES (Coventry University) as a Postdoctoral fellow in the research team of Profs Alfonso Jimenez and Helen Maddock, where I am assessing the effect of chemotherapy treatment-induced cardiotoxicity in vulnerable patient groups, such as children. Early assessment of cardiac injury and implementation of adjunct therapy options are explored in our diverse and dynamic team.

 

Research Interests

MicroRNA biomarkers ; Early detection of drug-induced cardiotoxicity ; Insulin resistance in women with Polycystic Ovarian Syndrome; Polycystic Ovarian Syndrome associated diabetes and cardiovascular diseases; Drug safety, validation and optimisation using in vitro disease models mimicking in vivo pathways

Vision Statement

 

Early detection of drug-induced cardiotoxicity is an important area of research, as reliable assessment method is still lacking specificity and sensitivity. A translational pre-clinical to clinical project including the latest molecular biology and genomic assays, including microRNA expression profiling, will aim to determine the feasibility of using a variety of biochemical and genomic microRNA biomarkers to help determine subclinical cardiac dysfunction in patients treated with chemotherapy. The intracellular pathways linked to cardiac injury develoment are unraveled and adjunct therapy options are explored. The research projects are instinctive progression of my current research expertise, combining genomic and molecular biology techniques to determine the complex links between drug safety interactions and pathophysiological disease conditions.

Education/Academic qualification

Degree, University of Copenhagen

1 Jan 200811 Mar 2011

Award Date: 11 Mar 2011

MSc, University of Copenhagen

1 Aug 199930 Sep 2005

Award Date: 30 Sep 2005

MBA, Niels Brock Copenhagen Business College

1 Jul 19991 Aug 1998

Award Date: 1 Jul 1999

Keywords

  • RM Therapeutics. Pharmacology
  • cardiovascular diseases
  • microRNA
  • adjunct therapy
  • biomarker
  • RC0254 Neoplasms. Tumors. Oncology (including Cancer)
  • cancer
  • RG Gynecology and obstetrics
  • polycystic ovarian syndrome
  • insulin resistance
  • RZ Other systems of medicine
  • organ culture

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