Research output

Research output per year 1985 1987 1989 1992 1997 2008 2016 2020 2022 2024

• 130 Article
• 10 Preprint
• 6 Review article
• 5 Conference article
• 9 More
  • 3 Chapter
  • 3 Conference proceeding
  • 2 Comment/debate
  • 1 Letter

Research output per year

Research output per year

Search results

• 2024

  The circularly permuted globin domain of androglobin exhibits atypical heme stabilization and nitric oxide interaction

  Reeder, B. J., Deganutti, G., Ukeri, J., Atanasio, S., Svistunenko, D. A., Ronchetti, C., Mobarec, J. C., Welbourn, E., Asaju, J., Vos, M. H., Wilson, M. T. & Reynolds, C. A., 14 May 2024, In: Chemical Science. 15, 18, p. 6738-6751 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Globin 100%
  • Neuroglobin 16%
  • Nitrite Reductase 16%
  • Hemeprotein 16%
  • Hemoprotein 16%
  1 Citation (Scopus)

  9 Downloads (Pure)
• 2023

  GWAS of random glucose in 476,326 individuals provide insights into diabetes pathophysiology, complications and treatment stratification

  Lagou, V., Jiang, L., Ulrich, A., Zudina, L., González, K. S. G., Balkhiyarova, Z., Faggian, A., Maina, J. G., Chen, S., Todorov, P. V., Sharapov, S., David, A., Marullo, L., Mägi, R., Rujan, R-M., Ahlqvist, E., Thorleifsson, G., Gao, Η., Εvangelou, Ε., Benyamin, B., & 78 othersScott, R. A., Isaacs, A., Zhao, J. H., Willems, S. M., Johnson, T., Gieger, C., Grallert, H., Meisinger, C., Müller-Nurasyid, M., Strawbridge, R. J., Goel, A., Rybin, D., Albrecht, E., Jackson, A. U., Stringham, H. M., Corrêa Jr., I. R., Farber-Eger, E., Steinthorsdottir, V., Uitterlinden, A. G., Munroe, P. B., Brown, M. J., Schmidberger, J., Holmen, O., Thorand, B., Hveem, K., Wilsgaard, T., Mohlke, K. L., Wang, Z., GWA-PA Consortium, Shmeliov, A., den Hoed, M., Loos, R. J. F., Kratzer, W., Mark, H., Koenig, W., Boehm, B. O., Tan, T. M., Tomas, A., Salem, V., Barroso, I., Tuomilehto, J., Boehnke, M., Florez, J. C., Hamsten, A., Watkins, H., Njølstad, I., Wichmann, H-E., Caulfield, M. J., Khaw, K. T., van Duijn, C. M., Hofman, A., Wareham, N. J., Langenberg, C., Whitfield, J. B., Martin, N. G., Montgomery, G., Scapoli, C., Tzoulaki, I., Elliott, P., Thorsteinsdottir, U., Stefansson, K., Brittain, E. L., McCarthy, M. I., Froguel, P., Sexton, P. M., Wootten, D. L., Groop, L., Dupuis, J., Meigs, J. B., Deganutti, G., Demirkan, A., Pers, T. H., Reynolds, C., Aulchenko, Y. S., Kaakinen, M. A., Jones, B. J., Prokopenko, I. & Meta-Analysis of Glucose and Insulin-related Traits Consortium (MAGIC), 7 Sept 2023, In: Nature Genetics. 55, 9, p. 1448-1461 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Glucose 100%
  • Introspection 100%
  • Genome-Wide Association Study 100%
  • Glucose Blood Level 60%
  • Agonist 20%
  14 Citations (Scopus)

  21 Downloads (Pure)

• Probing the Interactions of Thiazole Abietane Inhibitors with the Human Serine Hydrolases ABHD16A and ABHD12

  Ahonen, T. J., Ng, C. P., Farinha, B., Almeida, B., Victor, B., Reynolds, C., Kalso, E., Yli-Kauhaluoma, J. T., Greaves, J. & Moreira, V. M., 12 Oct 2023, In: ACS Medicinal Chemistry Letters. 14, 10, p. 1404 - 1410 7 p.

  Research output: Contribution to journal › Letter › peer-review

  Open Access

  File

  • Hydrolase 100%
  • Thiazole 100%
  • Enzyme Inhibition 33%
  • Nervous System Inflammation 33%
  1 Citation (Scopus)

  32 Downloads (Pure)

• Random glucose GWAS in 493,036 individuals provides insights into diabetes pathophysiology, complications and treatment stratification

  Meta-Analysis of Glucose and Insulin-related Traits Consortium (MAGIC), 2023, (Submitted) 60 p. (Nature Genetics).

  Research output: Working paper/Preprint › Preprint

  File

  • Glucose 100%
  • Introspection 100%
  • Genome-Wide Association Study 100%
  • Glucose Blood Level 80%
  • Agonist 20%
  18 Downloads (Pure)
• 2022

  A Pathway Model to Understand the Evolution of Spike Protein Binding to ACE2 in SARS-CoV-2 Variants

  Pipitò, L., Reynolds, C. A., Mobarec, J. C., Vickery, O. & Deganutti, G., 31 Oct 2022, In: Biomolecules. 12, 11, 12 p., 1607.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Binding Domain 100%
  • Receptor Binding 100%
  • Mutation 100%
  • SARS Coronavirus 66%
  • Spike 66%
  2 Citations (Scopus)

  63 Downloads (Pure)

• Biased Agonism and Polymorphic Variation at the GLP-1 Receptor: Implications for the Development of Personalised Therapeutics

  El Eid, L., Reynolds, C. A., Tomas, A. & Ben Jones, Oct 2022, In: Pharmacological Research. 184, 21 p., 106411.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Agonist 100%
  • Glucagon Like Peptide 1 Receptor 58%
  • Glucagon-Like Peptide 1 Receptor 58%
  • Combination Therapy 50%
  • Receptor 33%
  19 Citations (Scopus)

  327 Downloads (Pure)

• Dynamics of GLP-1R peptide agonist engagement are correlated with kinetics of G protein activation

  Deganutti, G., Liang, Y-L., Zhang, X., Khoshouei, M., Clydesdale, L., Belousoff, M. J., Venugopal, H., Truong, T. T., Glukhova, A., Keller, A. N., Gregory, K. J., Leach, K., Christopoulos, A., Danev, R., Reynolds, C. A., Zhao, P., Sexton, P. M. & Wootten, D., 10 Jan 2022, (E-pub ahead of print) In: Nature Communications. 13, 1, 18 p., 92.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • G Protein 100%
  • Glucagon-Like Peptide 1 Receptor 100%
  • Agonist 60%
  • Peptide 60%
  • Kinetics 40%
  34 Citations (Scopus)

  98 Downloads (Pure)

• Hidden GPCR structural transitions addressed by multiple walker supervised molecular dynamics (mwSuMD)

  Deganutti, G., Pipitò, L., Rujan, R. M., Weizmann, T., Griffin, P., Ciancetta, A., Moro, S. & Reynolds, C. A., 27 Oct 2022, bioRxiv.

  Research output: Working paper/Preprint › Preprint

  Open Access

  File

  • G Protein Coupled Receptor 100%
  • Molecular Dynamics 85%
  • Vasopressin 14%
  • Time 14%
  • G Protein 14%
  102 Downloads (Pure)

• Is the Stalk of the SARS-CoV-2 Spike Protein Druggable?

  Pipitò, L., Reynolds, C. A. & Deganutti, G., 14 Dec 2022, In: Viruses. 14, 12, 12 p., 2789.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Spike 100%
  • SARS Coronavirus 40%
  • Receptor Binding 40%
  • Recognition 40%
  • Binding Site 20%
  59 Downloads (Pure)

• Is The Stalk of the SARS-CoV-2 Spike Protein Druggable?

  Pipito, L., Reynolds, C. A. & Deganutti, G., 6 Oct 2022, bioRxiv, 20 p.

  Research output: Working paper/Preprint › Preprint

  • SARS Coronavirus 100%
  • Spike 100%
  • Protein 100%
  • Receptor Binding 66%
  • Binding Domain 33%

• Molecular dynamics simulations reveal the importance of conformational changes, glycosylation, mutations, and drug repurposing for the Sars-Cov-2 spike protein

  Pipitò, L., Rujan, R. M., Reynolds, C. A. & Deganutti, G., 3 Mar 2022, 22 p.

  Research output: Working paper/Preprint › Preprint

  Open Access

  • Spike 100%
  • Molecular Dynamics 50%
  • Conformation 50%
  • Mutation 50%
  • Exercise 25%

• Molecular dynamics studies reveal structural and functional features of the SARS‐CoV‐2 spike protein

  Pipitò, L., Rujan, RM., Reynolds, C. A. & Deganutti, G., Sept 2022, In: BioEssays. 44, 9, 14 p., 2200060.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Spike 100%
  • Exercise 20%
  • Epitope 20%
  • Conformational Transition 20%
  • Light 20%
  8 Citations (Scopus)

  71 Downloads (Pure)

• Selective activation of Gαob by an adenosine A1 receptor agonist elicits analgesia without cardiorespiratory depression

  Wall, M. J., Hill, E., Huckstepp, R., Barkan, K., Deganutti, G., Leuenberger, M., Preti, B., Winfield, I., Carvalho, S., Suchankova, A., Wei, H., Safitri, D., Huang, X., Imlach, W., Mache, C. L., Dean, E., Hume, C., Hayward, S., Oliver, J., Zhao, F-Y., & 5 othersSpanswick, D., Reynolds, C. A., Lochner, M., Ladds, G. & Frenguelli, B. G., 18 Jul 2022, In: Nature Communications. 13, 1, 22 p., 4150.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Agonist 100%
  • G Protein Coupled Receptor 50%
  • Depression 50%
  • Development 33%
  • Cardiorespiratory 33%
  20 Citations (Scopus)

  62 Downloads (Pure)

• The circularly permuted globin domain of Androglobin

  Reeder, B., Deganutti, G., Ukeri, J., Atanasio, S., Svistunenko, D., Ronchetti, C., Mobarec, J. C., Vos, M., Wilson, M. & Reynolds, C., 24 May 2022, Research Square, 19 p.

  Research output: Working paper/Preprint › Preprint

  Open Access

  File

  • Hemoglobin 100%
  • Iron 100%
  • Position 50%
  • Molecular Dynamics 50%
  • Tyrosine 50%
  83 Downloads (Pure)

• The Role of ICL1 and H8 in Class B1 GPCRs; Implications for Receptor Activation

  Winfield, I., Barkan, K., Routledge, S., Robertson, N. J., Harris, M., Jazayeri, A., Simms, J., Reynolds, C. A., Poyner, D. R. & Ladds, G., 13 Jan 2022, In: Frontiers in Endocrinology. 12, 14 p., 792912.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • G Protein Coupled Receptor 100%
  • Mutagenesis 50%
  • Calcitonin Gene Related Peptide 50%
  • Cyclic Adenosine Monophosphate 50%
  • Mutation 50%
  3 Citations (Scopus)

  56 Downloads (Pure)

• Understanding The Role of Heparinoids on the SARS-CoV-2 Spike Protein through Molecular Dynamics Simulations

  Pipito, L., Reynolds, C. A. & Deganutti, G., 6 Jul 2022.

  Research output: Working paper/Preprint › Preprint

  Open Access

• Understanding VPAC receptor family peptide binding and selectivity

  Piper, S. J., Deganutti, G., Lu, J., Zhao, P., Liang, Y-L., Lu, Y., Fletcher, M. M., Hossain, M. A., Christopoulos, A., Reynolds, C. A., Danev, R., Sexton, P. M. & Wootten, D., 16 Nov 2022, In: Nature Communications. 13, 20 p., 7013.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Vasoactive Intestinal Peptide 100%
  • Peptide 50%
  • Comprehension 37%
  • Agonist 12%
  • Molecular Dynamics 12%
  5 Citations (Scopus)

  77 Downloads (Pure)
• 2021

  Deciphering the Agonist Binding Mechanism to the Adenosine A1 Receptor

  Deganutti, G., Barkan, K., Preti, B., Leuenberger, M., Wall, M., Frenguelli, B. G., Lochner, M., Ladds, G. & Reynolds, C. A., 12 Feb 2021, In: ACS Pharmacology and Translational Science. 4, 1, p. 314-326 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Agonist 100%
  • Structure 50%
  • Adenosine 50%
  • Protein 33%
  • Molecular Dynamics 33%
  6 Citations (Scopus)

  64 Downloads (Pure)

• Exploring Ligand Binding to Calcitonin Gene-Related Peptide Receptors

  Deganutti, G., Atanasio, S., Rujan, R. M., Sexton, P. M., Wootten, D. L. & Reynolds, C., 26 Aug 2021, In: Frontiers in Molecular Biosciences. 8, 720561.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • G Protein Coupled Receptor 100%
  • Peptide Receptor 100%
  • Calcitonin Gene-Related Peptide 100%
  • Agonist 66%
  • Ligand Binding 66%
  4 Citations (Scopus)

  65 Downloads (Pure)

• Multisite Model of Allosterism for the Adenosine A1 Receptor

  Deganutti, G., Barkan, K., Ladds, G. & Reynolds, C. A., 26 Apr 2021, In: Journal of Chemical Information and Modeling. 61, 4, p. 2001-2015 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Positive Allosteric Modulator 100%
  • Adenosine 100%
  • Receptor 75%
  • Agonist 75%
  • Antagonist 50%
  8 Citations (Scopus)

  64 Downloads (Pure)

• Partial agonism improves the anti-hyperglycaemic efficacy of an oxyntomodulin-derived GLP-1R/GCGR co-agonist

  Pickford, P., Lucey, M., Rujan, R-M., McGlone, E. R., Bitsi, S., Ashford, F. B., Ivan R. Corrêa, J., Hodson, D. J., Tomas, A., Deganutti, G., Reynolds, C. A., Owen, B. M., Tan, T. M., Minnion, J., Jones, B. & Bloom, S. R., Sept 2021, In: Molecular Metabolism. 51, 101242.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Desensitization 100%
  • Internalization 100%
  • Dipeptidase 100%
  • Glucagon Receptor 100%
  • Partial Agonism 100%
  9 Citations (Scopus)

  64 Downloads (Pure)

• Peptidomimetic-based approach toward inhibitors of microbial trimethylamine lyases

  Gabr, M. T., Deganutti, G. & Reynolds, C. A., Feb 2021, In: Chemical Biology and Drug Design. 97, 2, p. 231-236 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Trimethylamine 100%
  • Peptidomimetic 75%
  • Peptidomimetic Agent 75%
  • Lyase 50%
  • Choline 25%
  4 Citations (Scopus)

  88 Downloads (Pure)

• Supervised molecular dynamics for exploring the druggability of the SARS-CoV-2 spike protein

  Deganutti, G., Prischi, F. & Reynolds, C. A., Feb 2021, In: Journal of Computer-Aided Molecular Design. 35, 2, p. 195-207 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Binding Domain 100%
  • Protein 100%
  • Spike 75%
  • Molecular Dynamics 50%
  • Virus 50%
  37 Citations (Scopus)

  33 Downloads (Pure)
• 2020

  A biased adenosine A₁R agonist elicits analgesia without cardiorespiratory depression

  Wall, M. J., Hill, E., Huckstepp, R., Barkan, K., Deganutti, G., Leuenberger, M., Preti, B., Winfield, I., Wei, H., Imlach, W., Dean, E., Hume, C., Hayward, S., Oliver, J., Zhao, F-Y., Spanswick, D., Reynolds, C. A., Lochner, M., Ladds, G. & Frenguelli, B. G., 5 Apr 2020, bioRxiv.

  Research output: Working paper/Preprint › Preprint

  Open Access

  • Agonist 100%
  • Depression 25%
  • Sedation 25%
  • Receptor 12%
  • Hypotension 12%

• Activation of the GLP-1 receptor by a non-peptidic agonist

  Zhao, P., Liang, Y. L., Belousoff, M. J., Deganutti, G., Fletcher, M. M., Willard, F. S., Bell, M. G., Christe, M. E., Sloop, K. W., Inoue, A., Truong, T. T., Clydesdale, L., Furness, S. G. B., Christopoulos, A., Wang, M. W., Miller, L. J., Reynolds, C. A., Danev, R., Sexton, P. M. & Wootten, D., 16 Jan 2020, In: Nature. 577, 7790, p. 432-436 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Agonist 100%
  • Peptide 80%
  • Movement (Physiology) 60%
  • Kinetics 40%
  • G Protein 40%
  119 Citations (Scopus)

• Addressing free fatty acid receptor 1 (FFAR1) activation using supervised molecular dynamics

  Atanasio, S., Deganutti, G. & Reynolds, C. A., Nov 2020, In: Journal of Computer-Aided Molecular Design. 34, 11, p. 1181–1193 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Free Fatty Acid Receptor 1 100%
  • Free Fatty Acids 16%
  • Computer-Aided Drug Design 16%
  5 Citations (Scopus)

  93 Downloads (Pure)

• A Multisite Model of Allosterism for the Adenosine A1 Receptor

  Deganutti, G., Barkan, K., Ladds, G. & Reynolds, C. A., 14 Oct 2020, bioRxiv.

  Research output: Working paper/Preprint › Preprint

  Open Access

  • Agonist 100%
  • Adenosine 100%
  • Antagonist 100%
  • Receptor 75%
  • Development 25%

• A Supervised Molecular Dynamics Approach to Unbiased Ligand-Protein Unbinding

  Deganutti, G., Moro, S. & Reynolds, C. A., 23 Mar 2020, In: Journal of Chemical Information and Modeling. 60, 3, p. 1804–1817 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Orexin 100%
  • Adenosine A1 Receptor 100%
  • Protein Ligand 100%
  • Drug Binding 100%
  • Epoxide Hydrolase 100%
  23 Citations (Scopus)

• Deciphering the Agonist Binding Mechanism to the Adenosine A1 Receptor

  Deganutti, G., Barkan, K., Preti, B., Leuenberger, M., Wall, M., Frenguelli, B., Lochner, M., Ladds, G. & Reynolds, C. A., 22 Oct 2020, bioRxiv.

  Research output: Working paper/Preprint › Preprint

  Open Access

  • Agonist 100%
  • Drug Development 66%
  • Adenosine A1 Receptor 66%
  • G Protein Coupled Receptor 66%
  • Receptor 33%

• Identification of Small-Molecule Positive Modulators of Calcitonin-like Receptor-Based Receptors

  Hendrikse, E. R., Liew, L. P., Bower, R. L., Bonnet, M., Jamaluddin, M. A., Prodan, N., Richards, K. D., Walker, C. S., Pairaudeau, G., Smith, D. M., Rujan, R. M., Sudra, R., Reynolds, C. A., Booe, J. M., Pioszak, A. A., Flanagan, J. U., Hay, M. P. & Hay, D. L., 10 Apr 2020, In: ACS Pharmacology and Translational Science. 3, 2, p. 305-320 16 p.

  Research output: Contribution to journal › Article › peer-review

  • Arrestin 100%
  16 Citations (Scopus)

• Rational development of a high-affinity secretin receptor antagonist

  Dong, M., Harikumar, K. G., Raval, S. R., Milburn, J. E., Clark, C., Alcala-Torano, R., Mobarec, J. C., Reynolds, C. A., Ghirlanda, G., Christopoulos, A., Wootten, D., Sexton, P. M. & Miller, L. J., Jul 2020, In: Biochemical Pharmacology. 177, 113929.

  Research output: Contribution to journal › Article › peer-review

  • Binding Affinity 100%
  • Peptide 100%
  • Biological Activity 75%
  • Secretin 75%
  • Secretin Receptor 50%
  6 Citations (Scopus)

• Structure and Dynamics of Adrenomedullin Receptors AM₁ and AM₂ Reveal Key Mechanisms in the Control of Receptor Phenotype by Receptor Activity-Modifying Proteins

  Liang, Y. L., Belousoff, M. J., Fletcher, M. M., Zhang, X., Khoshouei, M., Deganutti, G., Koole, C., Furness, S. G. B., Miller, L. J., Hay, D. L., Christopoulos, A., Reynolds, C. A., Danev, R., Wootten, D. & Sexton, P. M., 10 Apr 2020, In: ACS Pharmacology and Translational Science. 3, 2, p. 263-284 22 p.

  Research output: Contribution to journal › Article › peer-review

  • Cryo-Electron Microscopy 100%
  • Nidation 50%
  • Metabolism 50%
  • Intermedin 50%
  • Blood Vessel Tone 50%
  59 Citations (Scopus)

• Structure and dynamics of the active Gs-coupled human secretin receptor

  Dong, M., Deganutti, G., Piper, S. J., Liang, Y. L., Khoshouei, M., Belousoff, M. J., Harikumar, K. G., Reynolds, C. A., Glukhova, A., Furness, S. G. B., Christopoulos, A., Danev, R., Wootten, D., Sexton, P. M. & Miller, L. J., 18 Aug 2020, In: Nature Communications. 11, 17 p., 4137.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Secretin 100%
  • Peptide 57%
  • Dynamics 42%
  • Molecular Dynamics 28%
  • Cross-Link 28%
  37 Citations (Scopus)

  83 Downloads (Pure)

• Supervised molecular dynamics for exploring the druggability of the SARS-CoV-2 spike protein

  Deganutti, G., Prischi, F. & Reynolds, C. A., 26 Aug 2020, Research Square.

  Research output: Working paper/Preprint › Preprint

  Open Access

  • Receptor Binding 100%
  • Protein 66%
  • Severe Acute Respiratory Syndrome Coronavirus 2 50%
  • Spike 50%
  • Binding Domain 50%
• 2019

  Calcitonin gene-related peptide antagonists and therapeutic antibodies

  Rujan, R. M. & Reynolds, C. A., 1 Jan 2019, Handbook of Experimental Pharmacology. Brain, S. & Geppetti, P. (eds.). Springer New York LLC, Vol. 255. p. 169-192 24 p. (Handbook of Experimental Pharmacology; vol. 255).

  Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

  • Calcitonin Gene-Related Peptide 100%
  • Development 30%
  • Peptide Receptor 30%
  • Peptide 30%
  • Antibody 30%
  4 Citations (Scopus)

• Deconvoluting the molecular control of binding and signaling at the amylin 3 receptor: RAMP3 alters signal propagation through extracellular loops of the calcitonin receptor

  Pham, V., Zhu, Y., Dal Maso, E., Reynolds, C. A., Deganutti, G., Atanasio, S., Hick, C. A., Yang, D., Christopoulos, A., Hay, D. L., Furness, S. G. B., Wang, M. W., Wootten, D. & Sexton, P. M., 14 Jun 2019, In: ACS Pharmacology and Translational Science. 2, 3, p. 183-197 15 p.

  Research output: Contribution to journal › Article › peer-review

  • Satiety 100%
  • Stomach Emptying 100%
  9 Citations (Scopus)

• Peeking at G-protein-coupled receptors through the molecular dynamics keyhole

  Deganutti, G., Moro, S. & Reynolds, C. A., Mar 2019, In: Future Medicinal Chemistry. 11, 6, p. 599-610 12 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Molecular Dynamics 100%
  • Motion 25%
  • Membrane Protein 25%
  • Solid 25%
  • Allosteric Regulation 25%
  10 Citations (Scopus)

  25 Downloads (Pure)

• The Molecular Control of Calcitonin Receptor Signaling

  Dal Maso, E., Glukhova, A., Zhu, Y., Garcia-Nafria, J., Tate, C. G., Atanasio, S., Reynolds, C. A., Ramírez-Aportela, E., Carazo, J. M., Hick, C. A., Furness, S. G. B., Hay, D. L., Liang, Y. L., Miller, L. J., Christopoulos, A., Wang, M. W., Wootten, D. & Sexton, P. M., 8 Feb 2019, In: ACS Pharmacology and Translational Science. 2, 1, p. 31-51 21 p.

  Research output: Contribution to journal › Article › peer-review

  • Calcitonin Receptor 100%
  • Mutagenesis 75%
  • Peptide 75%
  • Calcitonin 75%
  • G Protein Coupled Receptor 50%
  37 Citations (Scopus)
• 2018

  Cryo-EM structure of the active, G _s -protein complexed, human CGRP receptor

  Liang, Y. L., Khoshouei, M., Deganutti, G., Glukhova, A., Koole, C., Peat, T. S., Radjainia, M., Plitzko, J. M., Baumeister, W., Miller, L. J., Hay, D. L., Christopoulos, A., Reynolds, C. A., Wootten, D. & Sexton, P. M., 12 Sept 2018, In: Nature. 561, 7724, p. 492-497 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Calcitonin Gene-Related Peptide 100%
  • Calcitonin Receptor 83%
  • Receptor Activity-Modifying Protein 66%
  • Peptide Receptor 50%
  • Transmembrane Domain 50%
  181 Citations (Scopus)

• Extracellular loops 2 and 3 of the calcitonin receptor selectively modify agonist binding and efficacy

  Dal Maso, E., Zhu, Y., Pham, V., Reynolds, C. A., Deganutti, G., Hick, C. A., Yang, D., Christopoulos, A., Hay, D. L., Wang, M. W., Sexton, P. M., Furness, S. G. B. & Wootten, D., Apr 2018, In: Biochemical Pharmacology. 150, p. 214-244 31 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Receptor 100%
  • Computed Tomography 100%
  • Agonist 66%
  • Peptide 66%
  • Calcitonin Receptor 33%
  24 Citations (Scopus)

  37 Downloads (Pure)

• Molecular Signature for Receptor Engagement in the Metabolic Peptide Hormone Amylin

  Bower, R. L., Yule, L., Rees, T. A., Deganutti, G., Hendrikse, E. R., Harris, P. W. R., Kowalczyk, R., Ridgway, Z., Wong, A. G., Swierkula, K., Raleigh, D. P., Pioszak, A. A., Brimble, M. A., Reynolds, C. A., Walker, C. S. & Hay, D. L., 14 Sept 2018, In: ACS Pharmacology and Translational Science. 1, 1, p. 32-49 18 p.

  Research output: Contribution to journal › Article › peer-review

  • Amylin 100%
  • Peptide 75%
  • Glucagon-Like Peptide-1 37%
  • Agonist 25%
  • Molecular Dynamics 25%
  48 Citations (Scopus)

• Photoaffinity cross-linking and unnatural amino acid mutagenesis reveal insights into calcitonin gene-related peptide binding to the calcitonin receptor-like receptor/receptor activity-modifying protein 1 (CLR/RAMP1) complex

  Simms, J., Uddin, R., Sakmar, T. P., Gingell, J. J., Garelja, M. L., Hay, D. L., Brimble, M. A., Harris, P. W. R., Reynolds, C. A. & Poyner, D. R., 14 Aug 2018, In: Biochemistry. 57, 32, p. 4915-4922 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cross-Link 100%
  • Genetic Code 50%
  • Fluorescein 50%
  • Photolysis 50%
  17 Citations (Scopus)

  108 Downloads (Pure)
• 2017

  Genetically encoded photocross-linkers determine the biological binding site of exendin-4 peptide in the N-terminal domain of the intact human glucagon-like peptide-1 receptor (GLP-1R)

  Koole, C., Reynolds, C. A., Mobarec, J. C., Hick, C., Sexton, P. M. & Sakmar, T. P., 28 Apr 2017, In: Journal of Biological Chemistry. 292, 17, p. 7131-7144 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Glucagon-Like Peptide 1 Receptor 100%
  • N-Terminus 60%
  • Peptide Receptor 60%
  • Peptide 60%
  • Length 40%
  37 Citations (Scopus)

  54 Downloads (Pure)

• High affinity binding of the peptide agonist TIP-39 to the parathyroid hormone 2 (PTH₂) receptor requires the hydroxyl group of Tyr-318 on transmembrane helix 5

  Weaver, R. E., Mobarec, J. C., Wigglesworth, M. J., Reynolds, C. A. & Donnelly, D., 1 Mar 2017, In: Biochemical Pharmacology. 127, p. 71-81 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Peptide 100%
  • Parathyroid Hormone 41%
  • Agonist 25%
  • Mutation 25%
  • Hydroxyl Group 25%
  6 Citations (Scopus)

  31 Downloads (Pure)
• 2016

  A Hydrogen-Bonded Polar Network in the Core of the Glucagon-Like Peptide-1 Receptor Is a Fulcrum for Biased Agonism: Lessons from Class B Crystal Structures

  Wootten, D., Reynolds, C. A., Koole, C., Smith, K. J., Mobarec, J. C., Simms, J., Quon, T., Coudrat, T., Furness, S. G. B., Miller, L. J., Christopoulos, A. & Sexton, P. M., Mar 2016, In: Molecular Pharmacology. 89, 3, p. 335-347 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Peptide 100%
  • Probe 50%
  • Crystal Structure 50%
  • Cyclic Adenosine Monophosphate 50%
  • Mutation 50%
  51 Citations (Scopus)

• Erratum: Receptor activity-modifying protein-directed G protein signaling specificity for the calcitonin gene-related peptide family of receptors (Journal of Biological Chemistry (2016) 291 (21925-21944) DOI: 10.1074/jbc.M116.751362)

  Weston, C., Winfield, I., Harris, M., Hodgson, R., Shah, A., Dowell, S. J., Mobarec, J. C., Woodcock, D. A., Reynolds, C. A., Poyner, D. R., Watkins, H. A. & Ladds, G., 2 Dec 2016, In: Journal of Biological Chemistry. 291, 49, 1 p., 21925.

  Research output: Contribution to journal › Comment/debate › peer-review

  Open Access

  • Guanine Nucleotide Binding Protein 100%
  • Calcitonin Gene Related Peptide 100%
  • 4 Iodo 2,5 Dimethoxyamphetamine 100%
  • Receptor 100%
  • Family 100%
  7 Citations (Scopus)

• Key interactions by conserved polar amino acids located at the transmembrane helical boundaries in Class B GPCRs modulate activation, effector specificity and biased signalling in the glucagon-like peptide-1 receptor

  Wootten, D., Reynolds, C. A., Smith, K. J., Mobarec, J. C., Furness, S. G. B., Miller, L. J., Christopoulos, A. & Sexton, P. M., 15 Oct 2016, In: Biochemical Pharmacology. 118, p. 68-87 20 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Receptor 100%
  • Glucagon Like Peptide 1 Receptor 100%
  • Eicosanoid Receptor 100%
  • Glucagon-Like Peptide 1 Receptor 100%
  • G Protein Coupled Receptor 75%
  37 Citations (Scopus)

  45 Downloads (Pure)

• Receptor activity-modifying protein-directed G protein signaling specificity for the calcitonin gene-related peptide family of receptors

  Weston, C., Winfield, I., Harris, M., Hodgson, R., Shah, A., Dowell, S. J., Mobarec, J. C., Woodlock, D. A., Reynolds, C. A., Poyner, D. R., Watkins, H. A. & Ladds, G., 14 Oct 2016, In: Journal of Biological Chemistry. 291, 42, p. 21925-21944 20 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Receptor Activity-Modifying Protein 100%
  • Calcitonin Gene-Related Peptide 66%
  • Calcitonin Receptor 50%
  • G Protein Coupled Receptor 50%
  • Yeast 50%
  67 Citations (Scopus)

  39 Downloads (Pure)

• Receptor activity-modifying proteins; multifunctional G protein-coupled receptor accessory proteins

  Hay, D. L., Walker, C. S., Gingell, J. J., Ladds, G., Reynolds, C. A. & Poyner, D. R., 11 Apr 2016, In: Biochemical Society Transactions. 44, 2, p. 568-573 6 p.

  Research output: Contribution to journal › Review article › peer-review

  • Receptor Activity Modifying Protein 100%
  • Receptor Activity-Modifying Protein 100%
  • G Protein Coupled Receptor 85%
  • Family 57%
  • Ligand Binding 28%
  33 Citations (Scopus)

• Receptor activity-modifying proteins 2 and 3 generate adrenomedullin receptor subtypes with distinct molecular properties

  Watkins, H. A., Chakravarthy, M., Abhayawardana, R. S., Gingell, J. J., Garelja, M., Pardamwar, M., McElhinney, J. M. W. R., Lathbridge, A., Constantine, A., Harris, P. W. R., Yuen, T. Y., Brimble, M. A., Barwell, J., Poyner, D. R., Woolley, M. J., Conner, A. C., Pioszak, A. A., Reynolds, C. A. & Hay, D. L., 27 May 2016, In: Journal of Biological Chemistry. 291, 22, p. 11657-11675 19 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Adrenomedullin 100%
  • Calcitonin Receptor 77%
  • RAMP2 33%
  • Receptor Activity-Modifying Protein 22%
  • Comprehension 22%
  37 Citations (Scopus)

  34 Downloads (Pure)