• 123 Citations
  • 5 h-Index
20132019

Research output per year

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Personal profile

Biography

I obtained my PhD in Cardiovascular Physiology and Pharmacology from Coventry University where I investigated the cardiotoxic effects of chemotherapies and identified strategies for cardioprotection. During my PhD and post-doctoral research, I developed, optimised and validated several novel assays to screen for cardiotoxicity. Some of the main outputs from my research include several publications in high quality journals, presentation in national and international conferences, several patent application and work towards the foundation of the University spin out company, InoCardia.

I currently work as a Post-Doctoral Research Fellow at the Centre of Sport Exercise and Life Science and as the Lead Research Scientist at InoCardia. My academic and commercial research projects are in the area of cardiac contractility, cardiotoxicity, myocardial ischaemia and reperfusion injury, cardioprotection, aging, obesity and development of novel assays to screen for contractility and cardiotoxicity. I supervise a number of post-doctoral researchers, PhD students and MSc students on a range of cardiovascular research projects.

Research Interests

Cardiac contractility, cardiotoxicity, mitochondrial energetics, Drug-induced cardiotoxicity/Safety Pharmacology, myocardial ischaemia and reperfusion injury, cardioprotection, obesity and aging.

Vision Statement

The main objectives of my research are the understanding of the physiological and pathophysiological processes of the heart using physiologically relevant techniques. The heart is continuously beating throughout life, understanding the biomechanics of contractility can provide crucial information on disease development and the effects of drugs on the heart. Assays that are currently used, poorly simulate and predict the true biomechanics of the heart and the effects of drugs. Obesity and aging are increasingly becoming concerning factors in health and disease management. I am investigating the effects of aging and obesity on cardiac contractility, myocardial ischaemia and reperfusion injury, cardioprotection and the effects of pharmaceutical compounds on the heart. the main aim of these research projects are to understand physiological and molecular changes in cardiovascular function and disease development.

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Research Output

  • 123 Citations
  • 5 h-Index
  • 8 Article
  • 1 Review article

Physiological work-loop contractions using isolated myocytes

Gharanei, M., Linekar, A., Chuizbaian, O., Wallis, R. & Maddock, H., 17 Oct 2019, In : Journal of Pharmacological and Toxicological Methods. 99, 10 p., 106595.

Research output: Contribution to journalArticle

The cardiac work-loop technique: An in vitro model for identifying and profiling drug-induced changes in inotropy using rat papillary muscles

Fletcher, S., Maddock, H., James, R. S., Wallis, R. & Gharanei, M., 26 Nov 2019, (Accepted/In press) In : Scientific Reports. 10, 13 p., 10:5258.

Research output: Contribution to journalArticle

Open Access
File
  • The cardiac work-loop technique to assess drug-induced changes in cardiac contractility

    Fletcher, S., James, R., Wallis, R., Maddock, H. & Gharanei, M., 17 Oct 2019, In : Journal of Pharmacological and Toxicological Methods. 99, Sept-Oct 2019, 106595.

    Research output: Contribution to journalArticle

    File
  • 8 Citations (Scopus)
    123 Downloads (Pure)

    Activities

    • 6 Participation in conference

    2015 Society of Toxicology Annual Meeting

    Ahmad Gharanei (Speaker)
    22 Jun 201526 Jun 2015

    Activity: Participating in or organising an eventParticipation in conference

    Annual meeting of the Safety Pharmacology Society (SPS)

    Ahmad Gharanei (Speaker)
    1 Oct 20124 Oct 2012

    Activity: Participating in or organising an eventParticipation in conference

    BSCR 2011 Autumn meeting

    Ahmad Gharanei (Speaker)
    5 Sep 20116 Sep 2011

    Activity: Participating in or organising an eventParticipation in conference

    BSCR 2011 Autumn meeting

    Ahmad Gharanei (Speaker)
    5 Sep 20116 Sep 2011

    Activity: Participating in or organising an eventParticipation in conference

    BSCR Autumn Meeting

    Ahmad Gharanei (Speaker)
    5 Sep 20106 Sep 2010

    Activity: Participating in or organising an eventParticipation in conference

    Thesis

    Assessment of Tiron as a cardioprotective agent

    Author: Chiuzbaian, O., 4 Jul 2019

    Supervisor: Mee, C. (Supervisor), Gharanei, M. (Supervisor), Hatch, E. (Supervisor) & Maddock, H. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy