Empowering patients through RENEW (RENEW-HOPE): A Digital Behavioural Change Intervention (DBCI) to improve treatment adherence in young kidney transplant recipients.

Activity: Talk or presentationOral presentation

Description

ntroduction: Non-adherence to treatment regimens is a significant
risk factor in reducing graft failure following kidney transplantation in ado-
lescent and young adult kidney transplant recipients aged 16 to 30 years.
This leads to adverse clinical outcomes such as graft rejections, graft loss
and decreased quality of life and puts a substantial economic burden on
healthcare systems. Recognizing the importance of involving patient and
public members in intervention development, this study presents RENEW
HOPE, a user driven DBCI targeting treatment adherence in young kidney
transplant recipients. By actively engaging patients and healthcare pro-
fessionals (HCPs) throughout the stage of intervention development it is
expected that its acceptability and effectiveness will increase.
Methods: A systematic review identified effective DBCIs components
based on PRISMS self-management taxonomy for improving treatment
adherence in young kidney transplant recipients. Subsequently, a qualita-
tive study explored barriers and facilitators to treatment adherence and
patient’s views on digital approaches, with themes resulting from thematic
analysis mapped against the Behaviour Change Technique (BCT) taxon-
omy to inform intervention functionalities and components. All together this
resulted in the first prototype, which will be refined based on feedback
gathered during focus groups and semi-structured interviews and followed
by a Patient and Public Involvement and Engagement (PPIE) activities
including young kidney transplant patients (n=3-5) and HCPs such as phy-
sicians (n=2), renal dietitians (n=2), and physiotherapists (n=2).
Results: Semi-structured interviews (n=14) and one focus group (n=5)
with young kidney transplant patients, emphasized the importance of
educational resources, guidance on post-transplant lifestyle factors (e.g.,
diet, exercise), social support, personalized goal-setting tools, gratitude
practices, and medication reminders. These findings were systematically
mapped onto the BCT taxonomy, identifying specific BCTs such as educa-
tion resources aligned with providing information and personalized goal
setting aligned with goal setting. This ensured that intervention compo-
nents were evidence-based, enhancing their effectiveness. RENEW HOPE
adopts a user-centric approach, refining intervention functionalities based
on PPIE input.
Conclusion: The active involvement of patients and HCPs in develop-
ing RENEW HOPE ensures a tailored approach to address the specific
needs of young kidney transplant recipients. Their invaluable contributions
guide the selection and refinement of intervention components aiming to
improve treatment adherence. By empowering young patients to self-
manage and adapt behaviour, RENEW HOPE offers potential for increasing
treatment adherence, reducing healthcare costs associated with transplant
complications, and laying a foundation for future research, particularly
through a feasibility Randomized Controlled Trial to test acceptability, feasi-
bility, and preliminary effectiveness.
Period24 Sept 2024
Event title30th The Transplantation Society 2024
Event typeConference
LocationIstanbul, TurkeyShow on map
Degree of RecognitionInternational